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Conference Labex Trail – Goran Angelovski

Friday 28 June 2019 / 14:30

Molecular fMRI with Bioresponsive Probes, Molecular fMRI with Bioresponsive Probes

Venue : CGFB


Goran Angelovski
Priv.-Doz. Dr. MR Neuroimaging Agents,
MPI for Biological Cybernetics,
Tuebingen, Germany

Invited by Yannick Crémillieux
DR CNRS ISM (UMR 5255)
Université de Bordeaux

Goran ANGELOVSKI received a diploma degree from the University in Belgrade, Ph.D. degree from the University in Dortmund and venia legendi (habilitation) from the University of Tuebingen. He is currently a research group leader at the MPI for Biological Cybernetics in Tuebingen. His research interests include the development of responsive molecular probes for functional MRI applications, from their preparation, to the final in vivo utilization.

Abstract

Molecular fMRI with Bioresponsive Probes Bioresponsive or smart contrast agents (SCAs) can substantially improve specificity of magnetic resonance imaging (MRI) in studying processes on molecular and cellular level. These probes are capable of alternating the MR image contrast upon change in the local environment, thus reporting the occurrence of a particular physiological or pathological process. Over the past several years, we developed a series of paramagnetic and biocompatible SCAs that strongly respond to calcium ions and amino acid neurotransmitters. Moreover, we validated their functionality in various MRI experiments in vitro, ex vivo, as well as in vivo. The most prominent example is utilization of a calcium-sensitive MRI probe for early detection and monitoring of brain ischemia. Wider involvement of this novel fMRI methodology can offer excellent perspectives for direct visualization and mapping of neural activity in unprecedented fashion.

Coming soon

  1. Seminar – Tomonori Takeuchi

    Monday 17 June 2019 / 11:30

    Memory consolidation, dopamine and two distinct novelty systems

  2. Seminar – David Stellwagen

    Thursday 20 June 2019 / 15:30

    TNF-mediated synaptic plasticity in the response to stress and reward

  3. Seminar – André Ramos

    Friday 21 June 2019 / 11:30

    Le long (et incertain) chemin entre les comportements liés à l'anxiété et les gènes sous-jacents

  4. Seminar – Manojkumar Saranathan

    Friday 21 June 2019 / 14:30

    Segmentation of thalamic nuclei from 3T MRI with applications

  5. Cajal course : Biosensors and actuators for cellular and systems neuroscience

    Sunday 23 June 2019 - Saturday 13 July 2019

    Talks are open to everyone

Details

Date:
Friday 28 June 2019
Time:
14:30
Event Category: