Chargement Évènements

« Tous les Évènements

Conférence Labex Trail – Goran Angelovski

vendredi 28 juin 2019 / 14:30

Molecular fMRI with Bioresponsive Probes

Lieu : CGFB


Goran Angelovski
Priv.-Doz. Dr. MR Neuroimaging Agents,
MPI for Biological Cybernetics,
Tuebingen, Germany

Invité par Yannick Crémillieux
DR CNRS ISM (UMR 5255)
Université de Bordeaux

Goran ANGELOVSKI received a diploma degree from the University in Belgrade, Ph.D. degree from the University in Dortmund and venia legendi (habilitation) from the University of Tuebingen. He is currently a research group leader at the MPI for Biological Cybernetics in Tuebingen. His research interests include the development of responsive molecular probes for functional MRI applications, from their preparation, to the final in vivo utilization.

Abstract

Molecular fMRI with Bioresponsive Probes Bioresponsive or smart contrast agents (SCAs) can substantially improve specificity of magnetic resonance imaging (MRI) in studying processes on molecular and cellular level. These probes are capable of alternating the MR image contrast upon change in the local environment, thus reporting the occurrence of a particular physiological or pathological process. Over the past several years, we developed a series of paramagnetic and biocompatible SCAs that strongly respond to calcium ions and amino acid neurotransmitters. Moreover, we validated their functionality in various MRI experiments in vitro, ex vivo, as well as in vivo. The most prominent example is utilization of a calcium-sensitive MRI probe for early detection and monitoring of brain ischemia. Wider involvement of this novel fMRI methodology can offer excellent perspectives for direct visualization and mapping of neural activity in unprecedented fashion.

Prochainement

  1. Séminaire – Tomonori Takeuchi

    lundi 17 juin 2019 / 11:30

    Memory consolidation, dopamine and two distinct novelty systems

  2. Séminaire – David Stellwagen

    jeudi 20 juin 2019 / 15:30

    TNF-mediated synaptic plasticity in the response to stress and reward

  3. Séminaire – André Ramos

    vendredi 21 juin 2019 / 11:30

    Le long (et incertain) chemin entre les comportements liés à l'anxiété et les gènes sous-jacents

  4. Séminaire – Manojkumar Saranathan

    vendredi 21 juin 2019 / 14:30

    Segmentation of thalamic nuclei from 3T MRI with applications

  5. Cajal course : Biosensors and actuators for cellular and systems neuroscience

    dimanche 23 juin 2019 - samedi 13 juillet 2019

    Les séminaires sont ouverts à tous.

Détails

Date :
vendredi 28 juin 2019
Heure :
14:30
Catégorie d’Évènement: