Vitamin E status and quality of life in the elderly: influence of inflammatory processes.
Br J Nutr. 2009-06-01; 102(10): 1390
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1. Br J Nutr. 2009 Nov;102(10):1390-4. doi: 10.1017/S0007114509990493.
Vitamin E status and quality of life in the elderly: influence of inflammatory
Capuron L(1), Moranis A, Combe N, Cousson-Gélie F, Fuchs D, De Smedt-Peyrusse V,
Barberger-Gateau P, Layé S.
(1)Laboratory of Psychoneuroimmunology, Nutrition and Genetics (PSYNUGEN), INRA
1286 – University Victor Segalen Bordeaux 2, CNRS 5226, 146 rue Léo Saignat,
Bordeaux F-33076, France.
Chronic low-grade inflammation is a characteristic of ageing that may lead to
alterations in health status and quality of life. In addition to intrinsic
biological factors, recent data suggest that poor nutritional habits may largely
contribute to this condition. The present study aimed at assessing mental and
physical components of quality of life and at determining their relationship to
vitamin E status, inflammation and tryptophan (TRP) metabolism in the elderly.
Sixty-nine elderly subjects recruited from the Three-City cohort study
participated in the study. Quality of life was assessed using the medical
outcomes study thirty-six-item short-form health survey (SF-36). Biological
assays included the measurement of plasma vitamin E (alpha-tocopherol),
inflammatory markers, including IL-6 and C-reactive protein, and TRP metabolism.
Results showed that participants with poor physical health status, as assessed by
the SF-36, exhibited lower circulating concentrations of alpha-tocopherol
together with increased concentrations of inflammatory markers. Similarly, poor
mental health scores on the SF-36 were associated with lower concentrations of
alpha-tocopherol, but also with decreased concentrations of TRP. These findings
indicate that nutritional status, notably as it relates to vitamin E, is
associated with immune function and quality of life in the elderly.
PMID: 19930773 [Indexed for MEDLINE]