Understanding corticotropin releasing factor neurobiology: contributions from mutant mice.
Neuropeptides. 1999-02-01; 33(1): 1-12
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1. Neuropeptides. 1999 Feb;33(1):1-12.
Understanding corticotropin releasing factor neurobiology: contributions from
Contarino A(1), Heinrichs SC, Gold LH.
(1)Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA,
Mice with transgenic expression or deletion of the CRF peptide, transgenic
expression of the CRF-BP or deletion of specific CRF receptor subtypes exist and
will be valuable for examining candidate mediators in animal model systems
recapitulating a variety of normal function. In particular, results described in
this review implicate CRF in acute emotional responses studied in animal models
of anxiety and drug abstinence. CRF also appears to play a role in behavioral and
physiological plasticity judging by alterations in HPA reactivity to stress,
information processing and energy balance regulation in CRF mutant models.
Accordingly, the creation of genetically engineered mice now permits the
evaluation of contributory roles for several CRF-related gene products in the
pathophysiology of a variety of complex behavioral disorders. For example, the
postulated causal linkage between overactivation of CRF systems and the
hyper-emotionality which characterizes human affective disorders can now be more
thoroughly evaluated by examining the phenotype of CRF mutant mice in animal
models of depression, dementia and substance abuse.
PMID: 10657465 [Indexed for MEDLINE]