The effects of FG 7142 on sensory-specific satiety in rats
Behavioural Brain Research. 2010-05-01; 209(1): 131-136
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1. Behav Brain Res. 2010 May 1;209(1):131-6. doi: 10.1016/j.bbr.2010.01.034. Epub
2010 Jan 29.
The effects of FG 7142 on sensory-specific satiety in rats.
Martire SI(1), Parkes SL, Westbrook RF.
(1)School of Psychology, University of New South Wales, Sydney 2052, Australia.
Three experiments used intake, clusters, and licks per cluster to study the
effects of the GABA inverse agonist, FG 7142, on sensory-specific satiety in
rats. In Experiment 1, rats were offered one of two palatable solutions and 30min
later tested with the same or the other solution. Rats that received the same
solution consumed less, exhibited fewer clusters, fewer licks per cluster and a
more rapid decline in rate of licking than rats tested with the other solution.
In Experiments 2 and 3, rats tested with the same solution under FG 7142 showed
fewer clusters and fewer licks per cluster than vehicle rats. Rats tested with
the other solution under FG 7142 showed fewer licks per cluster but more clusters
than vehicle rats. The results were discussed in terms of the distinction between
“liking” and “wanting” and the role of GABA in the former but not the latter.
PMID: 20117147 [Indexed for MEDLINE]