Roles of GABA, glutamate, acetylcholine and STN stimulation on thalamic VM in rats
NeuroReport. 1997-07-01; 8(11): 2601-2605
Read on PubMed
1. Neuroreport. 1997 Jul 28;8(11):2601-5. doi: 10.1097/00001756-199707280-00036.
Roles of GABA, glutamate, acetylcholine and STN stimulation on thalamic VM in
Gao D(1), Benazzouz A, Bressand K, Piallat B, Benabid AL.
(1)INSERM U. 318, Neurobiologie préclinique, CHU, Grenoble, France.
The effects of high frequency stimulation of the subthalamic nucleus (STN) and
of iontophoretic application of different neurotransmitters on neuronal
activities of the ventromedial thalamic nucleus (VM) were investigated in rats.
GABA, when applied iontophoretically, inhibited VM neuronal activity while
bicuculline, L-glutamic acid and acetylcholine enhanced the firing rates of the
same VM neurons. High frequency stimulation of the STN increased VM neuronal
activity in a frequency-dependent manner, which could be blocked by MK801. These
results suggest that GABAergic, cholinergic and glutamatergic input information
converge in the same VM neurons and that an increase in the delivery of
glutamatergic neurotransmitter activities in the VM is involved in the process
of high frequency stimulation of the STN.
PMID: 9261835 [Indexed for MEDLINE]