Neuromodulation in developing motor microcircuits.

Keith T Sillar, Denis Combes, John Simmers
Current Opinion in Neurobiology. 2014-12-01; 29: 73-81
DOI: 10.1016/j.conb.2014.05.009

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Sillar KT(1), Combes D(2), Simmers J(2).

Author information:
(1)School of Psychology and Neuroscience, University of St Andrews, Westburn
Lane, St Andrews, Fife KY16 9JP, Scotland, UK. Electronic address:
(2)Université de Bordeaux, Institut de Neurosciences Cognitives et Intégratives
d’Aquitaine, CNRS Unité Mixte de Recherche 5287, 146 rue Léo Saignat, 33076
Bordeaux, France.

Neuromodulation confers operational flexibility on motor network output and
resulting behaviour. Furthermore, neuromodulators play crucial long-term roles
in the assembly and maturational shaping of the same networks as they develop.
Although previous studies have identified such modulator-dependent contributions
to microcircuit ontogeny, some of the underlying mechanisms are only now being
elucidated. Deciphering the role of neuromodulatory systems in motor network
development has potentially important implications for post-lesional
regenerative strategies in adults.


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