Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate.
Sci Rep. 2012-11-30; 2(1):
DOI: 10.1038/srep00910
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1. Sci Rep. 2012;2:910. doi: 10.1038/srep00910. Epub 2012 Nov 30.
Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate.
Canron MH(1), Perret M, Vital A, Bézard E, Dehay B.
Author information:
(1)Univ. de Bordeaux, Institut des Maladies Neurodégénératives , UMR 5293,
F-33000 Bordeaux, France.
Since age-dependent deposition of Aβ-amyloid has been reported in the
Microcebusmurinus, we posited that this animal could as well be a model of
age-related synucleinopathy. We characterized the distribution of Aβ-amyloid,
α-synuclein and two of its modified forms in the brain of Microcebusmurinus aged
from 1.5 to 10 years. Intracytoplasmic α-synuclein aggregates were observed only
in aged animals in different brain regions, which were also phospho-Ser129 and
nitrated α-synuclein immunoreactive. Age-dependent α-synuclein aggregation occurs
spontaneously in mouse lemur primates. Microcebus murinus may provide a model to
study age-associated α-synucleinopathy and for testing putative therapeutic
interventions for both Alzheimer’s and Parkinson’s diseases.
DOI: 10.1038/srep00910
PMCID: PMC3510464
PMID: 23205271 [Indexed for MEDLINE]