Evolution of the dynamic properties of the cortex-basal ganglia network after dopaminergic depletion in rats
Neurobiology of Disease. 2012-05-01; 46(2): 402-413
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1. Neurobiol Dis. 2012 May;46(2):402-13. doi: 10.1016/j.nbd.2012.02.004. Epub 2012
Evolution of the dynamic properties of the cortex-basal ganglia network after
dopaminergic depletion in rats.
Dejean C(1), Nadjar A, Le Moine C, Bioulac B, Gross CE, Boraud T.
(1)CNRS, INCIA UMR 5287, F-33000 Bordeaux, France.
It is well established that parkinsonian syndrome is associated with alterations
of neuronal activity temporal pattern basal ganglia (BG). An increase in
synchronized oscillations has been observed in different BG nuclei in Parkinson’s
disease patients as well as animal models such as 6-hydroxydopamine treated rats.
We recently demonstrated that this increase in oscillatory synchronization is
present during high-voltage spindles (HVS) probably underpinned by the
disorganization of cortex-BG interactions. Here we investigated the time course
of both oscillatory and motor alterations. For that purpose we performed daily
simultaneous recordings of neuronal activity in motor cortex, striatum and
substantia nigra pars reticulata (SNr), before and after 6-hydroxydopamine lesion
in awake rats. After a brief non-dopamine-specific desynchronization, oscillatory
activity first increased during HVS followed by progressive motor impairment and
the shortening of SNr activation delay. While the oscillatory firing increase
reflects dopaminergic depletion, response alteration in SNr neurons is closely
related to motor symptom.
Copyright © 2012 Elsevier Inc. All rights reserved.
PMID: 22353564 [Indexed for MEDLINE]