
Thomas Boraud
Directeur de l'IMN / Directeur de Recherche / Praticien hospitalier Attaché
Directeur de recherche / CNRS/ Équipe
Neurosciences, humanités & société (Brun)
IMN clinique (Meissner)
IMN
Dynamique des Réseaux de l'Apprentissage Procédural (Leblois / Mallet)
IMN
/ Contact
+33 5 33 51 48 26
www.orcid.org/0000-0002-8942-0129
Publications
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One‐Year Substantia Nigra R2* Changes across Parkinson’s Disease Stages
Movement Disorders. 2026-04-27.
10.1002/mds.70331 -
Social hierarchy influences monkeys’ risky decisions
Commun Biol. 2026-03-11.
10.1038/s42003-026-09817-2 -
Reward-driven adaptation of movements requires strong recurrent basal ganglia–cortical loops
Proceedings of the National Academy of Sciences. 2025-12-11. 122(50)
10.1073/pnas.2515994122 -
The neoliberal leaning of the neuroscience discourse when it deals with mental health and learning disorders
Neurobiology of Disease. 2024-09-01. 199 : 106544.
10.1016/j.nbd.2024.106544 -
Amantadine use in the French prospective NS-Park cohort
J Neural Transm. 2024-04-05.
10.1007/s00702-024-02772-4 -
Trial of Lixisenatide in Early Parkinson’s Disease
N Engl J Med. 2024-04-04. 390(13) : 1176-1185.
10.1056/NEJMoa2312323 -
Care of Late-Stage Parkinsonism: Resource Utilization of the Disease in Five European Countries
Movement Disorders. 2024-02-29. 39(3) : 571-584.
10.1002/mds.29718 -
A response to claims of emergent intelligence and sentience in a dish
Neuron. 2023-03-01. 111(5) : 604-605.
10.1016/j.neuron.2023.02.009 -
Paul Broca: from fame to shame?
Brain. 2021-12-17.
10.1093/brain/awab444 -
Citation misuse and its effects on public health,Le mésusage des citations et ses conséquences en médecine
Med Sci (Paris). 2021-11-01. 37(11) : 1035-1041.
10.1051/medsci/2021142 -
A phase II study to evaluate the safety and efficacy of prasinezumab in early Parkinson’s disease (PASADENA): Rationale, design and baseline data
. 2021-04-15.
10.1101/2021.04.09.21251911 -
Special Issue Editorial: Basal Ganglia/Movement Disorders
Eur J of Neuroscience. 2021-04-01. 53(7) : 2045-2048.
10.1111/ejn.15204 -
Economic behaviours among non-human primates
Phil. Trans. R. Soc. B. 2021-01-11. 376(1819) : 20190676.
10.1098/rstb.2019.0676 -
The adaptive value of probability distortion and risk-seeking in macaques’ decision-making
Phil. Trans. R. Soc. B. 2021-01-11. 376(1819) : 20190668.
10.1098/rstb.2019.0668 -
What is the true discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia?
eLife. 2020-08-19. 9
10.7554/elife.57445 -
Optimizing Treatment in Undertreated Late-Stage Parkinsonism: A Pragmatic Randomized Trial
JPD. 2020-07-28. 10(3) : 1171-1184.
10.3233/JPD-202033 -
In vivo electrophysiological validation of DREADD-based modulation of pallidal neurons in the non-human primate.
Eur J Neurosci. 2020-05-11.
10.1111/ejn.14746 -
Publisher Correction: The globus pallidus orchestrates abnormal network dynamics in a model of Parkinsonism
Nat Commun. 2020-04-16. 11(1)
10.1038/s41467-020-15947-w -
The globus pallidus orchestrates abnormal network dynamics in a model of Parkinsonism
Nat Commun. 2020-03-26. 11(1)
10.1038/s41467-020-15352-3 -
Does newspapers coverage influence the citations count of scientific publications? An analysis of biomedical studies
Scientometrics. 2020-02-17.
10.1007/s11192-020-03380-1 -
Coordination over a unique medium of exchange under information scarcity
Palgrave Commun. 2019-12-01. 5(1)
10.1057/s41599-019-0362-2 -
An asymmetry of treatment between lotteries involving gains and losses in rhesus monkeys
Sci Rep. 2019-07-18. 9(1)
10.1038/s41598-019-46975-2 -
A Computational Model of Dual Competition between the Basal Ganglia and the Cortex
eNeuro. 2018-12-12. : ENEURO.0339-17.2018.
10.1523/ENEURO.0339-17.2018 -
A natural history of skills
Progress in Neurobiology. 2018-12-01. 171 : 114-124.
10.1016/j.pneurobio.2018.08.003 -
Do newspapers preferentially cover biomedical studies involving national scientists?
Public Underst Sci. 2018-10-29. : 096366251880980.
10.1177/0963662518809804 -
Naftazone in advanced Parkinson’s disease: An acute L-DOPA challenge randomized controlled trial
Parkinsonism & Related Disorders. 2018-10-01.
10.1016/j.parkreldis.2018.10.005 -
Cover
CNS Neurosci Ther. 2018-07-16. 24(8) : i-i.
10.1111/cns.13037 -
Social decision making in autism: On the impact of mirror neurons, motor control, and imitative behaviors
CNS Neurosci Ther. 2018-07-02. 24(8) : 669-676.
10.1111/cns.13001 -
Scientific Uncertainty in the Press: How Newspapers Describe Initial Biomedical Findings
Science Communication. 2018-01-12. 40(1) : 124-141.
10.1177/1075547017752166 -
Alterations in functional cortical hierarchy in hemiparkinsonian rats.
J. Neurosci.. 2017-07-07. 37(32) : 7669-7681.
10.1523/jneurosci.3257-16.2017 -
Memories of Opiate Withdrawal Emotional States Correlate with Specific Gamma Oscillations in the Nucleus Accumbens
Neuropsychopharmacology. 2017-06-01. 42(7) : 1558-1558.
10.1038/npp.2017.46 -
Poor replication validity of biomedical association studies reported by newspapers
PLoS ONE. 2017-02-21. 12(2) : e0172650.
10.1371/journal.pone.0172650 -
Low statistical power in biomedical science: a review of three human research domains
R. Soc. open sci.. 2017-02-01. 4(2) : 160254.
10.1098/rsos.160254 -
Memories of Opiate Withdrawal Emotional States Correlate with Specific Gamma Oscillations in the Nucleus Accumbens.
Neuropsychopharmacol. 2016-12-06. 42(5) : 1157-1168.
10.1038/npp.2016.272 -
Decision making under uncertainty in a spiking neural network model of the basal ganglia
J. Integr. Neurosci.. 2016-12-01. 15(04) : 515-538.
10.1142/S021963521650028X -
Replication Validity of Initial Association Studies: A Comparison between Psychiatry, Neurology and Four Somatic Diseases
PLoS ONE. 2016-06-23. 11(6) : e0158064.
10.1371/journal.pone.0158064 -
Inhibiting Lateral Habenula Improves L-DOPA-Induced Dyskinesia.
Biological Psychiatry. 2016-03-01. 79(5) : 345-353.
10.1016/j.biopsych.2014.08.022 -
The globus pallidus pars interna in goal-oriented and routine behaviors: Resolving a long-standing paradox.
Mov Disord.. 2016-02-22. 31(8) : 1146-1154.
10.1002/mds.26542 -
Arkypallidal Cells Send a Stop Signal to Striatum
Neuron. 2016-01-01. 89(2) : 308-316.
10.1016/j.neuron.2015.12.017 -
Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.
acta neuropathol commun. 2015-07-25. 3(1)
10.1186/s40478-015-0222-2 -
A Long Journey into Reproducible Computational Neuroscience
Front. Comput. Neurosci.. 2015-03-05. 9
10.3389/fncom.2015.00030 -
Easy rider: Monkeys learn to drive a wheelchair to navigate through a complex maze
PLoS ONE. 2014-05-15. 9(5) : e96275.
10.1371/journal.pone.0096275 -
The Michelin red guide of the brain: Role of dopamine in goal-oriented navigation
Front. Syst. Neurosci.. 2014-03-18. 8
10.3389/fnsys.2014.00032 -
Complex population response of dorsal putamen neurons predicts the ability to learn
PLoS ONE. 2013-11-14. 8(11) : e80683.
10.1371/journal.pone.0080683 -
Opiate dependence induces network state shifts in the limbic system
Neurobiology of Disease. 2013-11-01. 59 : 220-229.
10.1016/j.nbd.2013.07.012 -
Why am I lost without dopamine? Effects of 6-OHDA lesion on the encoding of reward and decision process in CA3
Neurobiology of Disease. 2013-11-01. 59 : 151-164.
10.1016/j.nbd.2013.07.014 -
Interaction between cognitive and motor cortico-basal ganglia loops during decision making: a computational study.
Journal of Neurophysiology. 2013-06-15. 109(12) : 3025-3040.
10.1152/jn.00026.2013 -
Coordinated reset has sustained aftereffects in Parkinsonian monkeys.
Ann Neurol.. 2012-11-01. 72(5) : 816-820.
10.1002/ana.23663 -
Why most biomedical findings echoed by newspapers turn out to be false: the case of attention deficit hyperactivity disorder.
PLoS ONE. 2012-09-12. 7(9) : e44275.
10.1371/journal.pone.0044275 -
Oscillatory entrainment of subthalamic nucleus neurons and behavioural consequences in rodents and primates
European Journal of Neuroscience. 2012-07-31. 36(9) : 3246-3257.
10.1111/j.1460-9568.2012.08246.x -
Evolution of the dynamic properties of the cortex-basal ganglia network after dopaminergic depletion in rats
Neurobiology of Disease. 2012-05-01. 46(2) : 402-413.
10.1016/j.nbd.2012.02.004 -
Where is my reward and how do I get it? Interaction between the hippocampus and the basal ganglia during spatial learning
Journal of Physiology-Paris. 2012-05-01. 106(3-4) : 72-80.
10.1016/j.jphysparis.2011.10.002 -
High resolution 3T fMRI in anesthetized monkeys
Journal of Neuroscience Methods. 2012-03-01. 205(1) : 86-95.
10.1016/j.jneumeth.2011.12.023 -
Closed-loop stimulation: The future of surgical therapy of brain disorders?
Movement Disorders. 2012-02-01. 27(2) : 200-200.
10.1002/mds.24884 -
What should be said to the lay public regarding ADHD etiology.
Am. J. Med. Genet.. 2011-08-31. 156(8) : 989-991.
10.1002/ajmg.b.31236 -
The translational value of the MPTP non-human primate model of Parkinsonism for deep brain stimulation research
2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2011-08-01.
10.1109/IEMBS.2011.6090148 -
Power Fluctuations in Beta and Gamma Frequencies in Rat Globus Pallidus: Association with Specific Phases of Slow Oscillations and Differential Modulation by Dopamine D-1 and D-2 Receptors
Journal of Neuroscience. 2011-04-20. 31(16) : 6098-6107.
10.1523/jneurosci.3311-09.2011 -
Power fluctuations in beta and gamma frequencies in rat globus pallidus: Association with specific phases of slow oscillations and differential modulation by dopamine D1 and D2 receptors
J. Neurosci.. 2011-04-20. 31(16) : 6098-6107.
10.1523/JNEUROSCI.3311-09.2011 -
Misrepresentation of neuroscience data might give rise to misleading conclusions in the media: the case of attention deficit hyperactivity disorder.
PLoS ONE. 2011-01-31. 6(1) : e14618.
10.1371/journal.pone.0014618 -
Basal ganglia preferentially encode context dependent choice in a two-armed bandit task
Front. Syst. Neurosci.. 2011-01-01. 5
10.3389/fnsys.2011.00023 -
Inhibition of dopamine uptake by D2 antagonists: An in vivo study
Journal of Neurochemistry. 2010-12-22. 116(3) : 449-458.
10.1111/j.1471-4159.2010.07125.x -
Deep brain stimulation changes basal ganglia output nuclei firing pattern in the dystonic hamster
Neurobiology of Disease. 2010-05-01. 38(2) : 288-298.
10.1016/j.nbd.2010.01.020 -
Brain hemispheres selectively track the expected value of contralateral options
J. Neurosci.. 2009-10-28. 29(43) : 13465-13472.
10.1523/JNEUROSCI.1500-09.2009 -
Dynamic changes in the cortex-basal ganglia network after dopamine depletion in the rat
Journal of Neurophysiology. 2008-07-01. 100(1) : 385-396.
10.1152/jn.90466.2008 -
Measure of the regularity of events in stochastic point processes, application to neuron activity analysis
2008 IEEE International Conference on Acoustics, Speech and Signal Processing. 2008-03-01.
10.1109/ICASSP.2008.4517653 -
Late emergence of synchronized oscillatory activity in the pallidum during progressive parkinsonism
European Journal of Neuroscience. 2007-09-14. 26(6) : 1701-1713.
10.1111/j.1460-9568.2007.05777.x -
Synchronous high-voltage spindles in the cortex-basal ganglia network of awake and unrestrained rats
Eur J of Neuroscience. 2007-02-01. 25(3) : 772-784.
10.1111/j.1460-9568.2007.05305.x -
Shaping of motor responses by incentive values through the basal ganglia.
Journal of Neuroscience. 2007-01-31. 27(5) : 1176-1183.
10.1523/jneurosci.3745-06.2007 -
Temporal and spatial alterations in GPi neuronal encoding might contribute to slow down movement in Parkinsonian monkeys.
European Journal of Neuroscience. 2006-08-01. 24(4) : 1201-1208.
10.1111/j.1460-9568.2006.04984.x -
Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracellular striatal dopamine.
Neurobiology of Disease. 2006-06-01. 22(3) : 586-598.
10.1016/j.nbd.2006.01.009 -
Competition between feedback loops underlies normal and pathological dynamics in the basal ganglia
Journal of Neuroscience. 2006-03-29. 26(13) : 3567-3583.
10.1523/JNEUROSCI.5050-05.2006 -
Emerging patterns of neuronal responses in supplementary and primary motor areas during sensorimotor adaptation
J. Neurosci.. 2005-11-23. 25(47) : 10941-10951.
10.1523/JNEUROSCI.0164-05.2005 -
Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations
Brain. 2005-08-25. 128(10) : 2372-2382.
10.1093/brain/awh616 -
Neuronal oscillations in the basal ganglia and movement disorders: Evidence from whole animal and human recordings
J. Neurosci.. 2004-10-20. 24(42) : 9240-9243.
10.1523/JNEUROSCI.3366-04.2004 -
Acquisition and generalization of visuomotor transformations by nonhuman primates
Exp Brain Res. 2004-10-05. 161(2) : 209-219.
10.1007/s00221-004-2061-4 -
Spike synchronization in the cortex-basal ganglia networks of parkinsonian primates reflects global dynamics of the local field potentials
J. Neurosci.. 2004-06-30. 24(26) : 6003-6010.
10.1523/JNEUROSCI.4848-03.2004 -
Electrophysiological and metabolic evidence that high-frequency stimulation of the subthalamic nucleus bridles neuronal activity in the subthalamic nucleus and the substantia nigra reticulata.
The FASEB Journal. 2003-10-01. 17(13) : 1820-1830.
10.1096/fj.03-0163com -
Preparatory activity in motor cortex reflects learning of local visuomotor skills
Nat Neurosci. 2003-07-20. 6(8) : 882-890.
10.1038/nn1097 -
Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function.
Nat Med. 2003-05-12. 9(6) : 762-767.
10.1038/nm875 -
Enhanced Synchrony among Primary Motor Cortex Neurons in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Primate Model of Parkinson’s Disease
J. Neurosci.. 2002-06-01. 22(11) : 4639-4653.
10.1523/jneurosci.22-11-04639.2002 -
From single extracellular unit recording in experimental and human Parkinsonism to the development of a functional concept of the role played by the basal ganglia in motor control.
Progress in Neurobiology. 2002-03-01. 66(4) : 265-283.
10.1016/s0301-0082(01)00033-8 -
Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alterations of pallidal neurones in the MPTP-treated monkey.
Brain. 2001-03-01. 124(3) : 546-557.
10.1093/brain/124.3.546 -
Pallidal border cells: an anatomical and electrophysiological study in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey.
Neuroscience. 2001-02-01. 103(1) : 117-123.
10.1016/s0306-4522(00)00546-7 -
Pallidal border cells: An anatomical and electrophysiological study in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey
Neuroscience. 2001-02-01. 103(1) : 117-123.
10.1016/S0306-4522(00)00546-7 -
Comparison of eight clinical rating scales used for the assessment of MPTP-induced parkinsonism in the Macaque monkey.
Journal of Neuroscience Methods. 2000-03-01. 96(1) : 71-76.
10.1016/s0165-0270(99)00184-3 -
Effects of riluzole on the electrophysiological activity of pallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey.
Neuroscience Letters. 2000-03-01. 281(2-3) : 75-78.
10.1016/s0304-3940(00)00780-1 -
Bicuculline injections into the rostral and caudal motor thalamus of the monkey induce different types of dystonia
Eur J of Neuroscience. 2000-03-01. 12(3) : 1033-1037.
10.1046/j.1460-9568.2000.00999.x -
Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice
Synapse. 2000-01-01. 38(3) : 363-368.
10.1002/1098-2396(20001201)38:3<363::AID-SYN16>3.0.CO;2-A -
From experimentation to the surgical treatment of Parkinson’s disease: prelude or suite in basal ganglia research?
Progress in Neurobiology. 1999-12-01. 59(5) : 509-532.
10.1016/s0301-0082(99)00015-5 -
Trichloroethylene and parkinsonism: a human and experimental observation.
Eur J Neurol. 1999-09-01. 6(5) : 609-611.
10.1046/j.1468-1331.1999.650609.x -
Cortical stimulation and epileptic seizure: a study of the potential risk in primates.
Neurosurgery. 1999-08-01. 45(2) : 346-350.
10.1097/00006123-199908000-00030 -
Involvement of the subthalamic nucleus in glutamatergic compensatory mechanisms.
European Journal of Neuroscience. 1999-06-01. 11(6) : 2167-2170.
10.1046/j.1460-9568.1999.00627.x -
Towards a dynamic approach of experimental parkinsonism
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1998-11-01. 22(8) : 1317-1329.
10.1016/S0278-5846(98)00072-4 -
Riluzole delayed appearance of parkinsonian motor abnormalities in a chronic MPTP monkey model.
European Journal of Pharmacology. 1998-09-01. 356(2-3) : 101-104.
10.1016/s0014-2999(98)00537-8 -
Riluzole delayed appearance of parkinsonian motor abnormalities in a chronic MPTP monkey model
European Journal of Pharmacology. 1998-09-01. 356(2-3) : 101-104.
10.1016/S0014-2999(98)00537-8 -
Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey.
Brain Research. 1998-03-01. 787(1) : 157-160.
10.1016/s0006-8993(97)01563-1 -
Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
Brain Research. 1998-03-01. 787(1) : 157-160.
10.1016/S0006-8993(97)01563-1 -
High-frequency stimulation of the globus pallidus internalis in Parkinson’s disease: A study of seven cases
Journal of Neurosurgery. 1997-10-01. 87(4) : 491-498.
10.3171/jns.1997.87.4.0491 -
Compensatory effects of glutamatergic inputs to the substantia nigra pars compacta in experimental parkinsonism.
Neuroscience. 1997-09-01. 81(2) : 399-404.
10.1016/s0306-4522(97)00226-1 -
Presymptomatic revelation of experimental parkinsonism.
NeuroReport. 1997-01-01. 8(2) : 435-438.
10.1097/00001756-199701200-00012 -
Quantification of motor slowness in Parkinson’s disease: Correlations between the tapping test and single joint ballistic movement parameters
Parkinsonism & Related Disorders. 1997-01-01. 3(1) : 47-50.
10.1016/S1353-8020(96)00039-9 -
Alleviation of experimental hemiparkinsonism by high-frequency stimulation of the subthalamic nucleus in primates: A comparison with L-Dopa treatment
Mov. Disord.. 1996-11-01. 11(6) : 627-632.
10.1002/mds.870110606 -
High frequency stimulation of the internal Globus Pallidus (GPi) simultaneously improves parkinsonian symptoms and reduces the firing frequency of GPi neurons in the MPTP-treated monkey.
Neuroscience Letters. 1996-08-01. 215(1) : 17-20.
10.1016/s0304-3940(96)12943-8 -
High frequency stimulation of the internal Globus Pallidus (GPi) simultaneously improves parkinsonian symptoms and reduces the firing frequency of GPi neurons in the MPTP-treated monkey
Neuroscience Letters. 1996-08-01. 215(1) : 17-20.
10.1016/S0304-3940(96)12943-8 -
The effect of riluzole on post-traumatic spinal cord injury in the rat
NeuroReport. 1996-01-01. 7(2) : 387-392.
10.1097/00001756-199601310-00003 -
Riluzole prevents MPTP-induced parkinsonism in the rhesus monkey: a pilot study
European Journal of Pharmacology. 1995-09-01. 284(3) : 299-307.
10.1016/0014-2999(95)00362-O -
Reversal of Rigidity and Improvement in Motor Performance by Subthalamic High‐frequency Stimulation in MPTP‐treated Monkeys
European Journal of Neuroscience. 1993-04-01. 5(4) : 382-389.
10.1111/j.1460-9568.1993.tb00505.x