
Agnès Nadjar
Enseignant-chercheur
Professeure / Université de Bordeaux/ Contact
www.orcid.org/0000-0002-3969-6530

Ma recherche actuelle vise à décrypter les effets des nutriments sur le métabolisme énergétique microglial dans le contexte de l’obésité. Ceci s’inscrit dans la continuité de mes travaux initiaux (2001-2010) sur le rôle de l’activation inflammatoire microgliale dans divers contextes physiopathologiques. Ce projet s’appuie également sur l’expertise acquise entre 2011 et 2020 quant à l’impact de la nutrition sur les interactions microglie-neurones dans le cerveau sain ou malade.
Axes de recherche
Axe principal
Axe secondaire
Publications
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Discovery of a new type of neuroimmune interaction in the aged brain’s response to energy surfeit
Agnes Nadjar.
Brain, Behavior, and Immunity. 2023-03-01.
10.1016/j.bbi.2023.03.010 -
Microglial homeostasis disruption modulates non-rapid eye movement sleep duration and neuronal activity in adult female mice
Katherine Picard, Giorgio Corsi, Fanny Decoeur, Maria Amalia Di Castro, Maude Bordeleau, Marine Persillet, Sophie Layé, Cristina Limatola, Marie-Ève Tremblay, Agnès Nadjar.
Brain, Behavior, and Immunity. 2023-01-01. 107 : 153-164.
10.1016/j.bbi.2022.09.016 -
Microglia states and nomenclature: A field at its crossroads
Rosa C. Paolicelli, Amanda Sierra, Beth Stevens, Marie-Eve Tremblay, (...) Agnes Nadjar, (...), Susanne A. Wolf, Long-Jun Wu, Tony Wyss-Coray.
Neuron. 2022-11-01. 110(21) : 3458-3483.
10.1016/j.neuron.2022.10.020 -
Nanoparticles: The new promise for region-specific targeting of microglia
Agnes Nadjar.
Matter. 2022-08-01. 5(8) : 2529-2530.
10.1016/j.matt.2022.06.048 -
Susceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia
Noelia Rodríguez-Iglesias, Agnès Nadjar, Amanda Sierra, Jorge Valero.
Int. J. Mol. Sci.. 2022-03-21. 23(6) : 3399.
10.3390/ijms23063399 -
Female Mice Susceptibility to the Dietary Omega-3/Omega-6 Fatty Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia
Noelia Rodríguez-Iglesias, Agnès Nadjar, Amanda Sierra, Jorge Valero.
. 2022-02-22.
10.20944/preprints202202.0265.v1 -
N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice.
Fanny Decoeur, Katherine Picard, Marie-Kim St-Pierre, Andrew D. Greenhalgh, Jean-Christophe Delpech, Alexandra Sere, Sophie Layé, Marie-Eve Tremblay, Agnès Nadjar.
Front. Cell. Neurosci.. 2022-02-10. 16
10.3389/fncel.2022.802411 -
Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner
Julia De Meij, Zain Alfanek, Lydie Morel, Fanny Decoeur, Quentin Leyrolle, Katherine Picard, Micael Carrier, Agnes Aubert, Alexandra Séré, Céline Lucas, Gerald Laforest, Jean-Christophe Helbling, Marie-Eve Tremblay, Daniela Cota, Marie-Pierre Moisan, Giovanni Marsicano, Sophie Layé, Agnès Nadjar.
Cannabis and Cannabinoid Research. 2021-12-01. 6(6) : 488-507.
10.1089/can.2020.0170 -
Complement C3 mediates early hippocampal neurodegeneration and memory impairment in experimental multiple sclerosis
Julien Bourel, Vincent Planche, Nadège Dubourdieu, Aymeric Oliveira, Alexandra Séré, Eva-Gunnel Ducourneau, Marion Tible, Marlène Maitre, Thierry Lesté-Lasserre, Agnes Nadjar, Aline Desmedt, Philippe Ciofi, Stéphane H. Oliet, Aude Panatier, Thomas Tourdias.
Neurobiology of Disease. 2021-12-01. 160 : 105533.
10.1016/j.nbd.2021.105533 -
N‐3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development
Quentin Leyrolle, Fanny Decoeur, Cyril Dejean, Galadriel Brière, Stephane Leon, Ioannis Bakoyiannis, Emilie Baroux, Tony‐Lee Sterley, Clémentine Bosch‐Bouju, Lydie Morel, Camille Amadieu, Cynthia Lecours, Marie‐Kim St‐Pierre, Maude Bordeleau, Véronique De Smedt‐Peyrusse, Alexandran Séré, Leslie Schwendimann, Stephane Grégoire, Lionel Bretillon, Niyazi Acar, Corinne Joffre, Guillaume Ferreira, Raluca Uricaru, Patricia Thebault, Pierre Gressens, Marie‐Eve Tremblay, Sophie Layé, Agnes Nadjar.
Glia. 2021-09-14.
10.1002/glia.24088 -
Microglia modulate hippocampal synaptic transmission and sleep duration along the light/dark cycle
Giorgio Corsi, Katherine Picard, Maria Amalia Castro, Stefano Garofalo, Federico Tucci, Giuseppina Chece, Claudio Percio, Maria Teresa Golia, Marcello Raspa, Ferdinando Scavizzi, Fanny Decoeur, Clotilde Lauro, Mara Rigamonti, Fabio Iannello, Davide Antonio Ragozzino, Eleonora Russo, Giovanni Bernardini, Agnès Nadjar, Marie Eve Tremblay, Claudio Babiloni, Laura Maggi, Cristina Limatola.
Glia. 2021-09-06. 70(1) : 89-105.
10.1002/glia.24090 -
Microglia–Neuron Crosstalk in Obesity: Melodious Interaction or Kiss of Death?
Stéphane Léon, Agnès Nadjar, Carmelo Quarta.
IJMS. 2021-05-15. 22(10) : 5243.
10.3390/ijms22105243 -
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain.
C. Madore, Q. Leyrolle, L. Morel, M. Rossitto, A. D. Greenhalgh, J. C. Delpech, M. Martinat, C. Bosch-Bouju, J. Bourel, B. Rani, C. Lacabanne, A. Thomazeau, K. E. Hopperton, S. Beccari, A. Sere, A. Aubert, V. De Smedt-Peyrusse, C. Lecours, K. Bisht, L. Fourgeaud, S. Gregoire, L. Bretillon, N. Acar, N. J. Grant, J. Badaut, P. Gressens, A. Sierra, O. Butovsky, M. E. Tremblay, R. P. Bazinet, C. Joffre, A. Nadjar, S. Layé.
Nat Commun. 2020-11-30. 11(1)
10.1038/s41467-020-19861-z -
Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime
Q. Leyrolle, F. Decoeur, G. Briere, C. Amadieu, A. R. A. A. Quadros, I. Voytyuk, C. Lacabanne, A. Benmamar-Badel, J. Bourel, A. Aubert, A. Sere, F. Chain, L. Schwendimann, B. Matrot, T. Bourgeois, S. Grégoire, J. G. Leblanc, A. De Moreno De Leblanc, P. Langella, G. R. Fernandes, L. Bretillon, C. Joffre, R. Uricaru, P. Thebault, P. Gressens, J. M. Chatel, S. Layé, A. Nadjar.
Neuropsychopharmacol.. 2020-08-11.
10.1038/s41386-020-00793-7 -
Role of Glia in the Regulation of Sleep in Health and Disease.
Stefano Garofalo, Katherine Picard, Cristina Limatola, Agnès Nadjar, Olivier Pascual, Marie‐Ève Tremblay.
Comprehensive Physiology. 2020-03-12. : 687-712.
10.1002/cphy.c190022 -
Direct and indirect effects of lipids on microglia function
Q. Leyrolle, S. Layé, A. Nadjar.
Neuroscience Letters. 2019-08-01. 708 : 134348.
10.1016/j.neulet.2019.134348 -
Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression
Richard P. Bazinet, Adam H. Metherel, Chuck T. Chen, Saame Raza Shaikh, Agnes Nadjar, Corinne Joffre, Sophie Layé.
Brain, Behavior, and Immunity. 2019-07-01.
10.1016/j.bbi.2019.07.001 -
Dietary N-3 PUFA deficiency affects sleep-wake activity in basal condition and in response to an inflammatory challenge in mice
F. Decoeur, A. Benmamar-Badel, Q. Leyrolle, M. Persillet, S. Layé, A. Nadjar.
Brain, Behavior, and Immunity. 2019-05-01.
10.1016/j.bbi.2019.05.016 -
Neuroinflammation and aging: Influence of dietary n-3 polyunsaturated fatty acid
Sophie Layé, Jean-Christophe Delpech, Véronique De Smedt-Peyrusse, Corinne Joffre, Thomas Larrieu, Charlotte Madore, Agnès Nadjar and Lucile Capuron.
OCL. 2011-11-15. 18(6)
10.1684/ocl.2011.0412 -
Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain
C. Rey, J.C. Delpech, C. Madore, A. Nadjar, A.D. Greenhalgh, C. Amadieu, A. Aubert, V. Pallet, C. Vaysse, S. Layé, C. Joffre.
Brain, Behavior, and Immunity. 2019-02-01. 76 : 17-27.
10.1016/j.bbi.2018.07.025 -
Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation.
V.F. Labrousse, Q. Leyrolle, C. Amadieu, A. Aubert, A Sere, E. Coutureau, S. Grégoire, L. Bretillon, V. Pallet, P. Gressens, C. Joffre, A. Nadjar, S. Layé.
Brain, Behavior, and Immunity. 2018-10-01. 73 : 427-440.
10.1016/j.bbi.2018.06.004 -
Role of metabolic programming in the modulation of microglia phagocytosis by lipids.
A. Nadjar.
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2018-08-01. 135 : 63-73.
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Maternal n-3 polyunsaturated fatty acid dietary supply modulates microglia lipid content in the offspring
Charlotte Rey, Agnès Nadjar, Florent Joffre, Camille Amadieu, Agnès Aubert, Carole Vaysse, Véronique Pallet, Sophie Layé, Corinne Joffre.
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2018-06-01. 133 : 1-7.
10.1016/j.plefa.2018.04.003 -
Antiinflammatory Properties of Dietary n-3 Polyunsaturated Fatty Acids Protect Against Cognitive Decline in Aging and Neurodegenerative Diseases
Agnes Nadjar, Quentin Leyrolle, Corinne Joffre, Sophie Layé.
Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases. 2018-01-01. : 367-384.
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Anti-inflammatory effects of omega-3 fatty acids in the brain: Physiological mechanisms and relevance to pharmacology
Sophie Layé, Agnès Nadjar, Corinne Joffre, Richard P. Bazinet.
Pharmacol Rev. 2017-12-07. 70(1) : 12-38.
10.1124/pr.117.014092 -
Bioactive lipids as new class of microglial modulators: When nutrition meets neuroimunology
A. Nadjar, Q. Leyrolle, C. Joffre, S. Laye.
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017-10-01. 79 : 19-26.
10.1016/j.pnpbp.2016.07.004 -
Roles of Microglial Phagocytosis and Inflammatory Mediators in the Pathophysiology of Sleep Disorders
Agnes Nadjar, Henna-Kaisa M. Wigren, Marie-Eve Tremblay.
Front. Cell. Neurosci.. 2017-08-30. 11
10.3389/fncel.2017.00250 -
Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation.
Caroline André, Omar Guzman-Quevedo, Charlotte Rey, Julie Rémus-Borel, Samantha Clark, Ashley Castellanos-Jankiewicz, Elodie Ladeveze, Thierry Leste-Lasserre, Agnes Nadjar, Djoher Nora Abrous, Sophie Laye, Daniela Cota.
Diabetes. 2016-11-30. 66(4) : 908-919.
10.2337/db16-0586 -
Modulation of brain PUFA content in different experimental models of mice
Corinne Joffre, Stéphane Grégoire, Véronique De Smedt, Niyazi Acar, Lionel Bretillon, Agnès Nadjar, Sophie Layé.
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-11-01. 114 : 1-10.
10.1016/j.plefa.2016.09.003 -
Enriched dairy fat matrix diet prevents early life lipopolysaccharide-induced spatial memory impairment at adulthood
A.L. Dinel, C. Rey, C. Baudry, C. Fressange-Mazda, P. Le Ruyet, A. Nadjar, P. Pallet, C. Joffre, S. Layé.
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-10-01. 113 : 9-18.
10.1016/j.plefa.2016.08.013 -
Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.
Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C. Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J. P. Deudero, Amy L. Brewster, Anne E. Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM. Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M. Encinas, Amanda Sierra.
PLoS Biol. 2016-09-20. 14(9) : e1002554.
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Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.
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PLoS Biol. 2016-09-20. 14(9) : e1002554.
10.1371/journal.pbio.1002554 -
Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro
C. Rey, A. Nadjar, B. Buaud, C. Vaysse, A. Aubert, V. Pallet, S. Layé, C. Joffre.
Brain, Behavior, and Immunity. 2016-07-01. 55 : 249-259.
10.1016/j.bbi.2015.12.013 -
N-3 polyunsaturated fatty acid and neuroinflammation in aging and Alzheimer’s disease
Sophie Layé, Charlotte Madore, Isabelle St-Amour, Jean-Christophe Delpech, Corinne Joffre, Agnès Nadjar, Frédéric Calon.
NUA. 2015-05-21. 3(1) : 33-47.
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Microglial Activation Enhances Associative Taste Memory through Purinergic Modulation of Glutamatergic Neurotransmission
J.-C. Delpech, N. Saucisse, S. L. Parkes, C. Lacabanne, A. Aubert, F. Casenave, E. Coutureau, N. Sans, S. Laye, G. Ferreira, A. Nadjar.
Journal of Neuroscience. 2015-02-18. 35(7) : 3022-3033.
10.1523/jneurosci.3028-14.2015 -
Interleukin-6 activates arginine vasopressin neurons in the supraoptic nucleus during immune challenge in rats
Karine Palin, Marie L. Moreau, Julie Sauvant, Hélène Orcel, Agnès Nadjar, Anne Duvoid-Guillou, Jennifer Dudit, Alain Rabié, Françoise Moos.
American Journal of Physiology-Endocrinology and Metabolism. 2009-06-01. 296(6) : E1289-E1299.
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Shaping of motor responses by incentive values through the basal ganglia.
B. Pasquereau, A. Nadjar, D. Arkadir, E. Bezard, M. Goillandeau, B. Bioulac, C. E. Gross, T. Boraud.
Journal of Neuroscience. 2007-01-31. 27(5) : 1176-1183.
10.1523/jneurosci.3745-06.2007 -
Phenotype of striatofugal medium spiny neurons in parkinsonian and dyskinetic nonhuman primates: a call for a reappraisal of the functional organization of the basal ganglia.
Nadjar A, Brotchie JM, Guigoni C, Li Q, Zhou SB, Wang GJ, Ravenscroft P, Georges F, Crossman AR, Bezard E..
Journal of Neuroscience. 2006-08-23. 26(34) : 8653-8661.
10.1523/jneurosci.2582-06.2006 -
Inactivation of the Cerebral NFκB Pathway Inhibits Interleukin-1β-Induced Sickness Behavior and c-Fos Expression in Various Brain Nuclei
Agnès Nadjar, Rose-Marie Bluthé, Michael J May, Robert Dantzer, Patricia Parnet.
Neuropsychopharmacol. 2005-05-18. 30(8) : 1492-1499.
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Signaling pathways of interleukin-1 actions in the brain: anatomical distribution of phospho-ERK1/2 in the brain of rat treated systemically with interleukin-1beta.
A. Nadjar, C. Combe, P. Busquet, R. Dantzer, P. Parnet.
Neuroscience. 2005-01-01. 134(3)
10.1016/j.neuroscience.2005.04.035 1104537600 -
NFκB Activates in vivo the Synthesis of Inducible Cox-2 in the Brain
Agnès Nadjar, Viviane Tridon, Michael J May, Sankar Ghosh, Robert Dantzer, Thierry Amédée, Patricia Parnet.
J Cereb Blood Flow Metab. 2005-03-09. 25(8) : 1047-1059.
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Book review: Interleukin protocols, methods in molecular medicine, vol. 70
Agnès Nadjar, Robert Dantzer.
Psychoneuroendocrinology. 2003-04-01. 28(3) : 475-476.
10.1016/s0306-4530(02)00071-9