Physiology and pathophysiology of executive functions
Physiologie et physiopathologie des fonctions executives
Notre objectif est de mieux comprendre les mécanismes neuronaux à la base des fonctions exécutives cognitives et motrices. Notre intérêt se porte particulièrement sur les aspects physiologiques et pathophysiologiques des processus de planification, prise de décision et d’apprentissage. Notre stratégie est fondée à la fois sur une approche systémique, centrée sur les interactions entre les différentes structures concernées (cortex, ganglions de la base, thalamus, lobe temporal médian, etc.), et sur une approche translationnelle.
Notre travail de recherche s’axe autour de sept thématiques :
- Physiologie du processus de décision
- Physiologie de la cognition spatiale
- Propriétés dynamiques des boucles corticales-sub-corticales
- Pathophysiologie des fonctions exécutives
- Thérapeutique expérimentale : interface cerveau-machine (Brain radio project)
- Ethique des neurosciences
English version
Our objective is to unravel the neural mechanisms underlying cognitive and motor executive functions. Our main interests are the physiology of the planning, decision making, learning processes and their pathophysiological aspects such as dystonia and obsessive-compulsive disorder. We adopted a phylogenetic approach that drive us to address the question in a broad variety of vertebrates such as salamander, rodents, primates (both human and non-human) and songbirds in order to unravel the emerging complexity of the system studied along the evolution tree. We based our research on system level theoretical models validated by experimental data. Our experimental procedures range from optognetic approaches coupled with single cell electrophysiology in anaesthetized animals to multiple electrode recording in awake and behaving primates. We also conduct several clinical studies in the fields of dystonia, OCD and Parkinson’s disease.
Selected publications
- Coordination over a unique medium of exchange under information scarcity. Aurélien Nioche, Basile Garcia, Germain Lefebvre, Thomas Boraud, Nicolas P. Rougier, Sacha Bourgeois-Gironde. Palgrave Commun. 2019-12-01. 5 (1)
- An asymmetry of treatment between lotteries involving gains and losses in rhesus monkeys. Aurélien Nioche, Sacha Bourgeois-Gironde, Thomas Boraud. Sci Rep. 2019-07-18. 9 (1)
- A Computational Model of Dual Competition between the Basal Ganglia and the Cortex. Meropi Topalidou, Daisuke Kase, Thomas Boraud, Nicolas P. Rougier. eNeuro. 2018-12-12. : ENEURO.0339-17.2018.
- A natural history of skills. Thomas Boraud, Arthur Leblois, Nicolas P. Rougier. Progress in Neurobiology. 2018-12-01. 171 : 114-124.
- Contrasting temporal difference and opportunity cost reinforcement learning in an empirical money-emergence paradigm. Germain Lefebvre, Aurélien Nioche, Sacha Bourgeois-Gironde, Stefano Palminteri. Proc Natl Acad Sci USA. 2018-11-15. : 201813197.
- Do newspapers preferentially cover biomedical studies involving national scientists?. Estelle Dumas-Mallet, Aran Tajika, Andy Smith, Thomas Boraud, Toshiaki A. Furukawa, François Gonon. Public Underst Sci. 2018-10-29. : 096366251880980.
- Naftazone in advanced Parkinson’s disease: An acute L-DOPA challenge randomized controlled trial. Jean-Christophe Corvol, Franck Durif, Wassilios G. Meissner, Jean-Philippe Azulay, Raphaël Haddad, Raquel Guimarães-Costa, Louise-Laure Mariani, Florence Cormier-Dequaire, Claire Thalamas, Monique Galitzky, Thomas Boraud, Bérengère Debilly, Alexandre Eusebio, Marion Houot, Estelle Dellapina, Véronique Chaigneau, Alexandrine Salis, Lucette Lacomblez, Laurent Benel, Olivier Rascol. Parkinsonism & Related Disorders. 2018-10-01.
- Cover. Radwa Khalil, Richard Tindle, Thomas Boraud, Ahmed A. Moustafa, Ahmed A. Karim. CNS Neurosci Ther. 2018-07-16. 24 (8) : i-i.
- Social decision making in autism: On the impact of mirror neurons, motor control, and imitative behaviors. Radwa Khalil, Richard Tindle, Thomas Boraud, Ahmed A. Moustafa, Ahmed A. Karim. CNS Neurosci Ther. 2018-07-02. 24 (8) : 669-676.
- Spatial Rule Learning and Corresponding CA1 Place Cell Reorientation Depend on Local Dopamine Release. Aude Retailleau, Genela Morris. Current Biology. 2018-03-01. 28 (6) : 836-846.e4.
- Scientific Uncertainty in the Press: How Newspapers Describe Initial Biomedical Findings. Estelle Dumas-Mallet, Andy Smith, Thomas Boraud, François Gonon. Science Communication. 2018-01-12. 40 (1) : 124-141.
- Sensorimotor Processing in the Basal Ganglia Leads to Transient Beta Oscillations during Behavior. Amin Mirzaei, Arvind Kumar, Daniel Leventhal, Nicolas Mallet, Ad Aertsen, Joshua Berke, Robert Schmidt. J. Neurosci.. 2017-10-16. 37 (46) : 11220-11232.
- Dual Competition between the Basal Ganglia and the Cortex: from Action-Outcome to Stimulus-Response. Meropi Topalidou, Daisuke Kase, Thomas Boraud, Nicolas P Rougier. . 2017-09-13.
- Alterations in functional cortical hierarchy in hemiparkinsonian rats.. Borbála Nóra Jávor-Duray, Martin Vinck, Marcel van der Roest, Erwan Bezard, Henk W. Berendse, Thomas Boraud, Pieter Voorn. J. Neurosci.. 2017-07-07. 37 (32) : 7669-7681.
- Poor replication validity of biomedical association studies reported by newspapers. Estelle Dumas-Mallet, Andy Smith, Thomas Boraud, François Gonon. PLoS ONE. 2017-02-21. 12 (2) : e0172650.
- Memories of Opiate Withdrawal Emotional States Correlate with Specific Gamma Oscillations in the Nucleus Accumbens.. Cyril Dejean, Mathieu Sitko, Paul Girardeau, Amine Bennabi, Stéphanie Caillé, Martine Cador, Thomas Boraud, Catherine Le Moine. Neuropsychopharmacol. 2016-12-06. 42 (5) : 1157-1168.
- One critic, two actors: Evidence for covert learning in the basal ganglia. Meropi Topalidou, Daisuke Kase, Thomas Boraud, Nicolas P. Rougier. . 2016-06-23.
- Replication Validity of Initial Association Studies: A Comparison between Psychiatry, Neurology and Four Somatic Diseases. Estelle Dumas-Mallet, Katherine Button, Thomas Boraud, Marcus Munafo, François Gonon. PLoS ONE. 2016-06-23. 11 (6) : e0158064.
- The Michelin red guide of the brain: Role of dopamine in goal-oriented navigation. Aude Retailleau, Thomas Boraud. Front. Syst. Neurosci.. 2014-03-18. 8
- Why am I lost without dopamine? Effects of 6-OHDA lesion on the encoding of reward and decision process in CA3. Aude Retailleau, Cyril Dejean, Benjamin Fourneaux, Xavier Leinekugel, Thomas Boraud. Neurobiology of Disease. 2013-11-01. 59 : 151-164.
- Recruitment of Perisomatic Inhibition during Spontaneous Hippocampal Activity In Vitro. Anna Beyeler, Aude Retailleau, Colin Molter, Amine Mehidi, Janos Szabadics, Xavier Leinekugel. PLoS ONE. 2013-06-21. 8 (6) : e66509.
- Where is my reward and how do I get it? Interaction between the hippocampus and the basal ganglia during spatial learning. Aude Retailleau, Stephanie Etienne, Martin Guthrie, Thomas Boraud. Journal of Physiology-Paris. 2012-05-01. 106 (3-4) : 72-80.
- Subthalamic deep brain stimulation increases pallidal firing rate and regularity. René Reese, Arthur Leblois, Frank Steigerwald, Monika Pötter-Nerger, Jan Herzog, H. Maximilian Mehdorn, Günther Deuschl, Wassilios G. Meissner, Jens Volkmann. Experimental Neurology. 2011-06-01. 229 (2) : 517-521.
Chef(s) d'équipe
Membres de l'équipe
Personnel(s) de recherche
Arthur Leblois
Leblois
(Chercheur)
Dominique Guehl Guehl (Enseignant-chercheur)
Emmanuel Cuny Cuny (Enseignant-chercheur - Praticien hospitalier)
François Gonon Gonon (Chercheur)
Nathalie Damon Perrière Damon Perrière (Praticien hospitalier)
Nicolas Mallet Mallet (Chercheur)
Véronique Michel Michel (Praticien hospitalier)
Dominique Guehl Guehl (Enseignant-chercheur)
Emmanuel Cuny Cuny (Enseignant-chercheur - Praticien hospitalier)
François Gonon Gonon (Chercheur)
Nathalie Damon Perrière Damon Perrière (Praticien hospitalier)
Nicolas Mallet Mallet (Chercheur)
Véronique Michel Michel (Praticien hospitalier)
Personnel(s) technique
Roman Ursu
Ursu
Post-doctorant(s)
Asier Aristieta
Aristieta
Aude Retailleau Retailleau
Estelle Dumas-Mallet Dumas-Mallet
Marc Deffains Deffains
Aude Retailleau Retailleau
Estelle Dumas-Mallet Dumas-Mallet
Marc Deffains Deffains
Doctorant(s)
Bastien Ribot
Ribot
Jérôme Aupy Aupy
Julien Engelhardt Engelhardt
Margaux Teil Teil
Sophie Gauthier Gauthier
Roman Ursu Ursu
Lise Guilhemsang Guilhemsang
Jérôme Aupy Aupy
Julien Engelhardt Engelhardt
Margaux Teil Teil
Sophie Gauthier Gauthier
Roman Ursu Ursu
Lise Guilhemsang Guilhemsang