Computational and systems neuroscience
Neurosciences computationnelles et des systèmes
Axes de recherche
Axes principaux :
Axes secondaires :
Mots clés
Alzheimer, Apprentissage, Assemblées neuronales, Attention, Codage et intégration du signal, Connectivité, Imagerie cellulaire in vitro ou in vivo, Intelligence artificielle et réalité virtuelle, Modélisation des neurones et des réseaux de neurones, Motivation, Mémoire, Mémorisation des perceptions sensorielles, Neurocomputation, Neurophysiologie, Optogénétique, Plasticité des réseaux, Plasticité synaptique, Prise de décision, Somesthésie, Système auditif et d’équilibrationSelected publications
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Can NMDA Spikes Dictate Computations of Local Networks and Behavior?.
Elisabete Augusto, Frédéric Gambino.
Front. Mol. Neurosci.. 2019-09-27. 12
DOI: 10.3389/fnmol.2019.00238 -
Non-linear dendritic integration in frontal circuits shapes sensory discrimination in rodents.
Mattia Aime, Elisabete Augusto, Vladimir Kouskoff, Christelle Martin, Yann Humeau, Nicolas Chenouard, Frédéric Gambino.
. 2019-03-06.
DOI: 10.1101/569137 -
Sensory-evoked LTP driven by dendritic plateau potentials in vivo.
Frédéric Gambino, Stéphane Pagès, Vassilis Kehayas, Daniela Baptista, Roberta Tatti, Alan Carleton, Anthony Holtmaat.
Nature. 2014-08-31. 515 (7525) : 116-119.
DOI: 10.1038/nature13664 -
The hippocampo-amygdala control of contextual fear expression is affected in a model of intellectual disability.
Chun-Lei Zhang, Xander Houbaert, Marilyn Lepleux, Melissa Deshors, Elisabeth Normand, Frédéric Gambino, Etienne Herzog, Yann Humeau.
Brain Struct Funct. 2014-08-27. 220 (6) : 3673-3682.
DOI: 10.1007/s00429-014-0882-x -
Modality-specific thalamocortical inputs instruct the identity of postsynaptic L4 neurons.
Gabrielle Pouchelon, Frédéric Gambino, Camilla Bellone, Ludovic Telley, Ilaria Vitali, Christian Lüscher, Anthony Holtmaat, Denis Jabaudon.
Nature. 2014-05-14. 511 (7510) : 471-474.
DOI: 10.1038/nature13390 -
Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein Kinase A Signaling.
Rajesh Jayachandran, Xiaolong Liu, Somdeb BoseDasgupta, Philipp Müller, Chun-Lei Zhang, Despina Moshous, Vera Studer, Jacques Schneider, Christel Genoud, Catherine Fossoud, Frédéric Gambino, Malik Khelfaoui, Christian Müller, Deborah Bartholdi, Helene Rossez, Michael Stiess, Xander Houbaert, Rolf Jaussi, Daniel Frey, Richard A. Kammerer, Xavier Deupi, Jean-Pierre de Villartay, Andreas Lüthi, Yann Humeau, Jean Pieters.
PLoS Biol. 2014-03-25. 12 (3) : e1001820.
DOI: 10.1371/journal.pbio.1001820 -
The coincident activation of lemniscal and paralemniscal inputs can drive synaptic plasticity in layer 2/3 pyramidal neurons of the mouse somatosensory cortex in vivo.
Kehayas Vassilis, Gambino Frédéric, Baptista Daniela, Pagès Stéphane, Holtmaat Anthony.
Front. Syst. Neurosci.. 2014-01-01. 8
DOI: 10.3389/conf.fnsys.2014.05.00040 -
Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway.
M. Khelfaoui, F. Gambino, X. Houbaert, B. Ragazzon, C. Muller, M. Carta, F. Lanore, B. N. Srikumar, P. Gastrein, M. Lepleux, C.-L. Zhang, M. Kneib, B. Poulain, S. Reibel-Foisset, N. Vitale, J. Chelly, P. Billuart, A. Luthi, Y. Humeau.
Philosophical Transactions of the Royal Society B: Biological Sciences. 2013-12-02. 369 (1633) : 20130160-20130160.
DOI: 10.1098/rstb.2013.0160 -
Target-specific vulnerability of excitatory synapses leads to deficits in associative memory in a model of intellectual disorder.
X. Houbaert, C.-L. Zhang, F. Gambino, M. Lepleux, M. Deshors, E. Normand, F. Levet, M. Ramos, P. Billuart, J. Chelly, E. Herzog, Y. Humeau.
Journal of Neuroscience. 2013-08-21. 33 (34) : 13805-13819.
DOI: 10.1523/JNEUROSCI.1457-13.2013 -
Spike-timing-dependent potentiation of sensory surround in the somatosensory cortex is facilitated by deprivation-mediated disinhibition.
Frédéric Gambino, Anthony Holtmaat.
Neuron. 2012-08-01. 75 (3) : 490-502.
DOI: 10.1016/j.neuron.2012.05.020 -
Synapses Let Loose for a Change: Inhibitory Synapse Pruning throughout Experience-Dependent Cortical Plasticity.
Frédéric Gambino, Anthony Holtmaat.
Neuron. 2012-04-01. 74 (2) : 214-217.
DOI: 10.1016/j.neuron.2012.04.005 -
In vivo evidence that TRAF4 is required for central nervous system myelin homeostasis.
Sébastien Blaise, Marie Kneib, Adrien Rousseau, Frederic Gambino, Marie-Pierre Chenard, Nadia Messadeq, Martine Muckenstrum, Fabien Alpy, Catherine Tomasetto, Yann Humeau, Marie-Christine Rio.
PLoS ONE. 2012-02-17. 7 (2) : e30917.
DOI: 10.1371/journal.pone.0030917 -
Forebrain deletion of αGDI in adult mice worsens the pre-synaptic deficit at cortico-lateral amygdala synaptic connections.
Veronica Bianchi, Frédéric Gambino, Luca Muzio, Daniela Toniolo, Yann Humeau, Patrizia D'Adamo.
PLoS ONE. 2012-01-23. 7 (1) : e29763.
DOI: 10.1371/journal.pone.0029763 -
Pre and Post Synaptic NMDA Effects Targeting Purkinje Cells in the Mouse Cerebellar Cortex.
Etienne Lonchamp, Frédéric Gambino, Jean Luc Dupont, Frédéric Doussau, Antoine Valera, Bernard Poulain, Jean-Louis Bossu.
PLoS ONE. 2012-01-19. 7 (1) : e30180.
DOI: 10.1371/journal.pone.0030180 -
The coffin-lowry syndrome-associated protein RSK2 and neurosecretion.
M. Zeniou-Meyer, F. Gambino, Mohamed-Raafet Ammar, Y. Humeau, N. Vitale.
Cell Mol Neurobiol. 2010-11-01. 30 (8) : 1401-1406.
DOI: 10.1007/s10571-010-9578-9 -
Synaptic maturation at cortical projections to the lateral amygdala in a mouse model of rett syndrome.
Frédéric Gambino, Malik Khelfaoui, Bernard Poulain, Thierry Bienvenu, Jamel Chelly, Yann Humeau.
PLoS ONE. 2010-07-02. 5 (7) : e11399.
DOI: 10.1371/journal.pone.0011399 -
IL1RAPL1 controls inhibitory networks during cerebellar development in mice.
Frédéric Gambino, Marie Kneib, Alice Pavlowsky, Henriette Skala, Stéphane Heitz, Nicolas Vitale, Bernard Poulain, Malik Khelfaoui, Jamel Chelly, Pierre Billuart, Yann Humeau.
European Journal of Neuroscience. 2009-10-01. 30 (8) : 1476-1486.
DOI: 10.1111/j.1460-9568.2009.06975.x -
L-type voltage-dependent Ca2+ channels mediate expression of presynaptic LTP in amygdala.
Elodie Fourcaudot, Frederic Gambino, Guillaume Casassus, Bernard Poulain, Yann Humeau, Andreas Lüthi.
Nat Neurosci. 2009-08-02. 12 (9) : 1093-1095.
DOI: 10.1038/nn.2378 -
X-linked mental retardation: focus on synaptic function and plasticity.
Yann Humeau, Frédéric Gambino, Jamel Chelly, Nicolas Vitale.
Journal of Neurochemistry. 2009-04-01. 109 (1) : 1-14.
DOI: 10.1111/j.1471-4159.2009.05881.x -
cAMP/PKA signaling and RIM1α mediate presynaptic LTP in the lateral amygdala.
E. Fourcaudot, F. Gambino, Y. Humeau, G. Casassus, H. Shaban, B. Poulain, A. Luthi.
Proceedings of the National Academy of Sciences. 2008-09-24. 105 (39) : 15130-15135.
DOI: 10.1073/pnas.0806938105 -
IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation.
F. Gambino, A. Pavlowsky, A. Begle, J.-L. Dupont, N. Bahi, R. Courjaret, R. Gardette, H. Hadjkacem, H. Skala, B. Poulain, J. Chelly, N. Vitale, Y. Humeau.
Proceedings of the National Academy of Sciences. 2007-05-14. 104 (21) : 9063-9068.
DOI: 10.1073/pnas.0701133104