Computational and systems neuroscience
Neocortical function and plasticity underlie the remarkable adaptive skills of mammals. Among different projects, our team is studying how the prefrontal cortex computes and adapts its strategies through experience and learning to optimally select the sequence of actions that is expected to produce the most beneficial outcome. We developed an entirely in vivo multidisciplinary approach combining electrophysiology and functional imaging (intrinsic and voltage-sensitive dyes imaging), multiphoton laser-scanning microscopy, gene transfer and optogenetic during behavior in head-fixed and freely-moving mice.
Innovative techniques: in vivo patch-clamp and optogenetic, chronic two-photon imaging during behavior. decision-making in virtual reality. high-dimentional analysis of brain circuit.
Mots clés
Alzheimer, Apprentissage, Assemblées neuronales, Attention, Codage et intégration du signal, Connectivité, Imagerie cellulaire in vitro ou in vivo, Intelligence artificielle et réalité virtuelle, Modélisation des neurones et des réseaux de neurones, Motivation, Mémoire, Mémorisation des perceptions sensorielles, Neurocomputation, Neurophysiologie, Optogénétique, Plasticité des réseaux, Plasticité synaptique, Somesthésie, Système auditif et d’équilibration, decision-makingSelected publications
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Can NMDA Spikes Dictate Computations of Local Networks and Behavior?
Elisabete Augusto, Frédéric Gambino.
Front. Mol. Neurosci.. 2019-09-27. 12
DOI: 10.3389/fnmol.2019.00238 -
Non-linear dendritic integration in frontal circuits shapes sensory discrimination in rodents
Mattia Aime, Elisabete Augusto, Vladimir Kouskoff, Christelle Martin, Yann Humeau, Nicolas Chenouard, Frédéric Gambino.
. 2019-03-06.
DOI: 10.1101/569137 -
Sensory-evoked LTP driven by dendritic plateau potentials in vivo
Frédéric Gambino, Stéphane Pagès, Vassilis Kehayas, Daniela Baptista, Roberta Tatti, Alan Carleton, Anthony Holtmaat.
Nature. 2014-08-31. 515 (7525) : 116-119.
DOI: 10.1038/nature13664 -
The hippocampo-amygdala control of contextual fear expression is affected in a model of intellectual disability
Chun-Lei Zhang, Xander Houbaert, Marilyn Lepleux, Melissa Deshors, Elisabeth Normand, Frédéric Gambino, Etienne Herzog, Yann Humeau.
Brain Struct Funct. 2014-08-27. 220 (6) : 3673-3682.
DOI: 10.1007/s00429-014-0882-x -
Modality-specific thalamocortical inputs instruct the identity of postsynaptic L4 neurons
Gabrielle Pouchelon, Frédéric Gambino, Camilla Bellone, Ludovic Telley, Ilaria Vitali, Christian Lüscher, Anthony Holtmaat, Denis Jabaudon.
Nature. 2014-05-14. 511 (7510) : 471-474.
DOI: 10.1038/nature13390 -
Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein Kinase A Signaling
Rajesh Jayachandran, Xiaolong Liu, Somdeb BoseDasgupta, Philipp Müller, Chun-Lei Zhang, Despina Moshous, Vera Studer, Jacques Schneider, Christel Genoud, Catherine Fossoud, Frédéric Gambino, Malik Khelfaoui, Christian Müller, Deborah Bartholdi, Helene Rossez, Michael Stiess, Xander Houbaert, Rolf Jaussi, Daniel Frey, Richard A. Kammerer, Xavier Deupi, Jean-Pierre de Villartay, Andreas Lüthi, Yann Humeau, Jean Pieters.
PLoS Biol. 2014-03-25. 12 (3) : e1001820.
DOI: 10.1371/journal.pbio.1001820 -
The coincident activation of lemniscal and paralemniscal inputs can drive synaptic plasticity in layer 2/3 pyramidal neurons of the mouse somatosensory cortex in vivo
Kehayas Vassilis, Gambino Frédéric, Baptista Daniela, Pagès Stéphane, Holtmaat Anthony.
Front. Syst. Neurosci.. 2014-01-01. 8
DOI: 10.3389/conf.fnsys.2014.05.00040 -
Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway
M. Khelfaoui, F. Gambino, X. Houbaert, B. Ragazzon, C. Muller, M. Carta, F. Lanore, B. N. Srikumar, P. Gastrein, M. Lepleux, C.-L. Zhang, M. Kneib, B. Poulain, S. Reibel-Foisset, N. Vitale, J. Chelly, P. Billuart, A. Luthi, Y. Humeau.
Philosophical Transactions of the Royal Society B: Biological Sciences. 2013-12-02. 369 (1633) : 20130160-20130160.
DOI: 10.1098/rstb.2013.0160 -
Target-specific vulnerability of excitatory synapses leads to deficits in associative memory in a model of intellectual disorder
X. Houbaert, C.-L. Zhang, F. Gambino, M. Lepleux, M. Deshors, E. Normand, F. Levet, M. Ramos, P. Billuart, J. Chelly, E. Herzog, Y. Humeau.
Journal of Neuroscience. 2013-08-21. 33 (34) : 13805-13819.
DOI: 10.1523/JNEUROSCI.1457-13.2013 -
Spike-timing-dependent potentiation of sensory surround in the somatosensory cortex is facilitated by deprivation-mediated disinhibition
Frédéric Gambino, Anthony Holtmaat.
Neuron. 2012-08-01. 75 (3) : 490-502.
DOI: 10.1016/j.neuron.2012.05.020 -
Synapses Let Loose for a Change: Inhibitory Synapse Pruning throughout Experience-Dependent Cortical Plasticity
Frédéric Gambino, Anthony Holtmaat.
Neuron. 2012-04-01. 74 (2) : 214-217.
DOI: 10.1016/j.neuron.2012.04.005 -
In vivo evidence that TRAF4 is required for central nervous system myelin homeostasis
Sébastien Blaise, Marie Kneib, Adrien Rousseau, Frederic Gambino, Marie-Pierre Chenard, Nadia Messadeq, Martine Muckenstrum, Fabien Alpy, Catherine Tomasetto, Yann Humeau, Marie-Christine Rio.
PLoS ONE. 2012-02-17. 7 (2) : e30917.
DOI: 10.1371/journal.pone.0030917 -
Forebrain deletion of αGDI in adult mice worsens the pre-synaptic deficit at cortico-lateral amygdala synaptic connections
Veronica Bianchi, Frédéric Gambino, Luca Muzio, Daniela Toniolo, Yann Humeau, Patrizia D'Adamo.
PLoS ONE. 2012-01-23. 7 (1) : e29763.
DOI: 10.1371/journal.pone.0029763 -
Pre and Post Synaptic NMDA Effects Targeting Purkinje Cells in the Mouse Cerebellar Cortex
Etienne Lonchamp, Frédéric Gambino, Jean Luc Dupont, Frédéric Doussau, Antoine Valera, Bernard Poulain, Jean-Louis Bossu.
PLoS ONE. 2012-01-19. 7 (1) : e30180.
DOI: 10.1371/journal.pone.0030180 -
The coffin-lowry syndrome-associated protein RSK2 and neurosecretion
M. Zeniou-Meyer, F. Gambino, Mohamed-Raafet Ammar, Y. Humeau, N. Vitale.
Cell Mol Neurobiol. 2010-11-01. 30 (8) : 1401-1406.
DOI: 10.1007/s10571-010-9578-9 -
Synaptic maturation at cortical projections to the lateral amygdala in a mouse model of rett syndrome
Frédéric Gambino, Malik Khelfaoui, Bernard Poulain, Thierry Bienvenu, Jamel Chelly, Yann Humeau.
PLoS ONE. 2010-07-02. 5 (7) : e11399.
DOI: 10.1371/journal.pone.0011399 -
IL1RAPL1 controls inhibitory networks during cerebellar development in mice
Frédéric Gambino, Marie Kneib, Alice Pavlowsky, Henriette Skala, Stéphane Heitz, Nicolas Vitale, Bernard Poulain, Malik Khelfaoui, Jamel Chelly, Pierre Billuart, Yann Humeau.
European Journal of Neuroscience. 2009-10-01. 30 (8) : 1476-1486.
DOI: 10.1111/j.1460-9568.2009.06975.x -
L-type voltage-dependent Ca2+ channels mediate expression of presynaptic LTP in amygdala
Elodie Fourcaudot, Frederic Gambino, Guillaume Casassus, Bernard Poulain, Yann Humeau, Andreas Lüthi.
Nat Neurosci. 2009-08-02. 12 (9) : 1093-1095.
DOI: 10.1038/nn.2378 -
X-linked mental retardation: focus on synaptic function and plasticity
Yann Humeau, Frédéric Gambino, Jamel Chelly, Nicolas Vitale.
Journal of Neurochemistry. 2009-04-01. 109 (1) : 1-14.
DOI: 10.1111/j.1471-4159.2009.05881.x -
cAMP/PKA signaling and RIM1α mediate presynaptic LTP in the lateral amygdala
E. Fourcaudot, F. Gambino, Y. Humeau, G. Casassus, H. Shaban, B. Poulain, A. Luthi.
Proceedings of the National Academy of Sciences. 2008-09-24. 105 (39) : 15130-15135.
DOI: 10.1073/pnas.0806938105 -
IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation
F. Gambino, A. Pavlowsky, A. Begle, J.-L. Dupont, N. Bahi, R. Courjaret, R. Gardette, H. Hadjkacem, H. Skala, B. Poulain, J. Chelly, N. Vitale, Y. Humeau.
Proceedings of the National Academy of Sciences. 2007-05-14. 104 (21) : 9063-9068.
DOI: 10.1073/pnas.0701133104
Team leader
Team member(s)
Chercheurs, Praticiens hospitaliers...
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Aron De Miranda
De Miranda
Doctorant(s)
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC