Matthieu Sainlos

Chercheur - Responsable de la plateforme Biochimie

Chercheur - PhD (CR) / CNRS

/ Équipe

Biologie cellulaire (Natacha Retailleau Olivier Thoumine)
IINS

Dynamique de l'organisation et des fonctions synaptiques (Choquet)
IINS

/ Contact

+33 5 33 51 47 31

www.orcid.org/0000-0001-5465-5641

/ Adresse
IINS - UMR 5297 - CNRS - Université de Bordeaux - Centre Broca Nouvelle-Aquitaine - 146 rue Léo-Saignat - CS 61292 CASE 130 - 33076 Bordeaux cedex -France

See the english version

Publications

Engineering paralog-specific PSD-95 recombinant binders as minimally interfering multimodal probes for advanced imaging techniques
Charlotte Rimbault, Christelle Breillat, Benjamin Compans, Estelle Toulmé, Filipe Nunes Vicente, Monica Fernandez-Monreal, Patrice Mascalchi, Camille Genuer, Virginia Puente-Muñoz, Isabel Gauthereau, Eric Hosy, Stéphane Claverol, Gregory Giannone, Ingrid Chamma, Cameron D Mackereth, Christel Poujol, Daniel Choquet, Matthieu Sainlos.
eLife. 2024-01-03. 13
10.7554/eLife.69620
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Andrea Toledo, Mathieu Letellier, Giorgia Bimbi, Béatrice Tessier, Sophie Daburon, Alexandre Favereaux, Ingrid Chamma, Kristel Vennekens, Jeroen Vanderlinden, Matthieu Sainlos, Joris de Wit, Daniel Choquet, Olivier Thoumine.
eLife. 2022-05-09. 11
10.7554/elife.75233
High-Resolution Fluorescence Imaging Combined With Computer Simulations to Quantitate Surface Dynamics and Nanoscale Organization of Neuroligin-1 at Synapses.
Matthieu Lagardère, Adèle Drouet, Matthieu Sainlos, Olivier Thoumine.
Front. Synaptic Neurosci.. 2022-04-25. 14
10.3389/fnsyn.2022.835427
Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration
Amine Mehidi, Frieda Kage, Zeynep Karatas, Maureen Cercy, Matthias Schaks, Anna Polesskaya, Matthieu Sainlos, Alexis M. Gautreau, Olivier Rossier, Klemens Rottner, Grégory Giannone.
Nat Cell Biol. 2021-11-01. 23(11) : 1148-1162.
10.1038/s41556-021-00786-8
Role of regulatory C‐terminal motifs in synaptic confinement of LRRTM2
Konstantina Liouta, Julia Chabbert, Sebastien Benquet, Béatrice Tessier, Vincent Studer, Matthieu Sainlos, Joris De Wit, Olivier Thoumine, Ingrid Chamma.
Biol. Cell. 2021-09-27.
10.1111/boc.202100026
Advanced imaging and labelling methods to decipher brain cell organization and function
Daniel Choquet, Matthieu Sainlos, Jean-Baptiste Sibarita.
Nat Rev Neurosci. 2021-03-12.
10.1038/s41583-021-00441-z
Correction: Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency
Kalina T Haas, Benjamin Compans, Mathieu Letellier, Thomas M Bartol Jr, Dolors Grillo-Bosch, Terrence J Sejnowski, Matthieu Sainlos, Daniel Choquet, Olivier Thoumine.
eLife. 2020-12-16.
10.7554/eLife.65689
Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
Charlotte Rimbault, Kashyap Maruthi, Christelle Breillat, Camille Genuer, Sara Crespillo, Virginia Puente-Muñoz, Ingrid Chamma, Isabel Gauthereau, Ségolène Antoine, Coraline Thibaut, Fabienne Wong Jun Tai, Benjamin Dartigues, Dolors Grillo-Bosch, Stéphane Claverol, Christel Poujol, Daniel Choquet, Cameron D. Mackereth, Matthieu Sainlos.
Nat Commun. 2019-10-04. 10(1)
10.1038/s41467-019-12528-4
Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis
Morgane Rosendale, Thi Nhu Ngoc Van, Dolors Grillo-Bosch, Silvia Sposini, Léa Claverie, Isabel Gauthereau, Stéphane Claverol, Daniel Choquet, Matthieu Sainlos, David Perrais.
Nat Commun. 2019-10-01. 10(1)
10.1038/s41467-019-12434-9
TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering
Edoardo Moretto, Anna Longatti, Luca Murru, Ingrid Chamma, Alessandro Sessa, Jonathan Zapata, Eric Hosy, Matthieu Sainlos, Julien Saint-Pol, Eric Rubinstein, Daniel Choquet, Vania Broccoli, Giampietro Schiavo, Olivier Thoumine, Maria Passafaro.
Cell Reports. 2019-10-01. 29(5) : 1130-1146.e8.
10.1016/j.celrep.2019.09.051
Biophysical mechanisms underlying the membrane trafficking of synaptic adhesion molecules.
Ingrid Chamma, Matthieu Sainlos, Olivier Thoumine.
Neuropharmacology. 2019-03-01.
10.1016/j.neuropharm.2019.02.037
Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models
Hongyu Zhang, Chunlei Zhang, Jean Vincent, Diana Zala, Caroline Benstaali, Matthieu Sainlos, Dolors Grillo-Bosch, Sophie Daburon, Françoise Coussen, Yoon Cho, Denis J. David, Frederic Saudou, Yann Humeau, Daniel Choquet.
Nat Commun. 2018-10-15. 9(1)
10.1038/s41467-018-06675-3
Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses
Blanka Kellermayer, Joana S. Ferreira, Julien Dupuis, Florian Levet, Dolors Grillo-Bosch, Lucie Bard, Jeanne Linarès-Loyez, Delphine Bouchet, Daniel Choquet, Dmitri A. Rusakov, Pierre Bon, Jean-Baptiste Sibarita, Laurent Cognet, Matthieu Sainlos, Ana Luisa Carvalho, Laurent Groc.
Neuron. 2018-10-01. 100(1) : 106-119.e7.
10.1016/j.neuron.2018.09.012
A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation
Mathieu Letellier, Zsófia Szíber, Ingrid Chamma, Camille Saphy, Ioanna Papasideri, Béatrice Tessier, Matthieu Sainlos, Katalin Czöndör, Olivier Thoumine.
Nat Commun. 2018-09-28. 9(1)
10.1038/s41467-018-06220-2
Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency
Kalina T Haas, Benjamin Compans, Mathieu Letellier, Thomas M Bartol, Dolors Grillo-Bosch, Terrence J Sejnowski, Matthieu Sainlos, Daniel Choquet, Olivier Thoumine, Eric Hosy.
eLife. 2018-07-25. 7
10.7554/eLife.31755
CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity
Patricio Opazo, Silvia Viana da Silva, Mario Carta, Christelle Breillat, Steven J. Coultrap, Dolors Grillo-Bosch, Matthieu Sainlos, Françoise Coussen, K. Ulrich Bayer, Christophe Mulle, Daniel Choquet.
Cell Reports. 2018-06-01. 23(11) : 3137-3145.
10.1016/j.celrep.2018.05.036
CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity
Patricio Opazo, Silvia Viana da Silva, Mario Carta, Christelle Breillat, Steven J. Coultrap, Dolors Grillo-Bosch, Matthieu Sainlos, Françoise Coussen, K. Ulrich Bayer, Christophe Mulle, Daniel Choquet.
Cell Reports. 2018-06-01. 23(11) : 3137-3145.
10.1016/j.celrep.2018.05.036
Optimized labeling of membrane proteins for applications to super-resolution imaging in confined cellular environments using monomeric streptavidin
Ingrid Chamma, Olivier Rossier, Grégory Giannone, Olivier Thoumine, Matthieu Sainlos.
Nat Protoc. 2017-03-09. 12(4) : 748-763.
10.1038/nprot.2017.010
Nanoscale organization of synaptic adhesion proteins revealed by single-molecule localization microscopy
Ingrid Chamma, Florian Levet, Jean-Baptiste Sibarita, Matthieu Sainlos, Olivier Thoumine.
Neurophoton. 2016-11-03. 3(4) : 041810.
10.1117/1.NPh.3.4.041810
Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin.
Ingrid Chamma, Mathieu Letellier, Corey Butler, Béatrice Tessier, Kok-Hong Lim, Isabel Gauthereau, Daniel Choquet, Jean-Baptiste Sibarita, Sheldon Park, Matthieu Sainlos, Olivier Thoumine.
Nat Comms. 2016-03-16. 7 : 10773.
10.1038/ncomms10773
Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95.
Anne-Sophie Hafner, Andrew C. Penn, Dolors Grillo-Bosch, Natacha Retailleau, Christel Poujol, Amandine Philippat, Françoise Coussen, Matthieu Sainlos, Patricio Opazo, Daniel Choquet.
Neuron. 2015-04-01. 86(2) : 475-489.
10.1016/j.neuron.2015.03.013
Inhibition of PDZ domain-mediated interactions
Dolors Grillo-Bosch, Daniel Choquet, Matthieu Sainlos.
Drug Discovery Today: Technologies. 2013-12-01. 10(4) : e531-e540.
10.1016/j.ddtec.2012.10.003
Neurexin-1β Binding to Neuroligin-1 Triggers the Preferential Recruitment of PSD-95 versus Gephyrin through Tyrosine Phosphorylation of Neuroligin-1
Grégory Giannone, Magali Mondin, Dolors Grillo-Bosch, Béatrice Tessier, Edouard Saint-Michel, Katalin Czöndör, Matthieu Sainlos, Daniel Choquet, Olivier Thoumine.
Cell Reports. 2013-06-01. 3(6) : 1996-2007.
10.1016/j.celrep.2013.05.013
Caged mono- and divalent ligands for light-assisted disruption of PDZ domain-mediated interactions
Matthieu Sainlos, Wendy S. Iskenderian-Epps, Nelson B. Olivier, Daniel Choquet, Barbara Imperiali.
J. Am. Chem. Soc.. 2013-03-13. 135(12) : 4580-4583.
10.1021/ja309870q
Regulation of AMPA receptor surface diffusion by PSD-95 slots
Patricio Opazo, Matthieu Sainlos, Daniel Choquet.
Current Opinion in Neurobiology. 2012-06-01. 22(3) : 453-460.
10.1016/j.conb.2011.10.010
Paromomycin and neomycin B derived cationic lipids: Synthesis and transfection studies
Mathieu Mével, Matthieu Sainlos, Benoît Chatin, Noufissa Oudrhiri, Michèle Hauchecorne, Olivier Lambert, Jean-Pierre Vigneron, Pierre Lehn, Bruno Pitard, Jean-Marie Lehn.
Journal of Controlled Release. 2012-03-01. 158(3) : 461-469.
10.1016/j.jconrel.2011.12.019
Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization.
Matthieu Sainlos, Cezar Tigaret, Christel Poujol, Nelson B Olivier, Lucie Bard, Christelle Breillat, Kevin Thiolon, Daniel Choquet, Barbara Imperiali.
Nat Chem Biol. 2010-12-26. 7(2) : 81-91.
10.1038/nchembio.498
Dynamic and specific interaction between synaptic NR2-NMDA receptor and PDZ proteins
L. Bard, M. Sainlos, D. Bouchet, S. Cousins, L. Mikasova, C. Breillat, F. A. Stephenson, B. Imperiali, D. Choquet, L. Groc.
Proceedings of the National Academy of Sciences. 2010-10-25. 107(45) : 19561-19566.
10.1073/pnas.1002690107
Monitoring protein interactions and dynamics with solvatochromic fluorophores
Galen S. Loving, Matthieu Sainlos, Barbara Imperiali.
Trends in Biotechnology. 2010-02-01. 28(2) : 73-83.
10.1016/j.tibtech.2009.11.002
A general screening strategy for peptide-based fluorogenic ligands: Probes for dynamic studies of PDZ domain-mediated interactions
Matthieu Sainlos, Wendy S. Iskenderian, Barbara Imperiali.
J. Am. Chem. Soc.. 2009-05-20. 131(19) : 6680-6682.
10.1021/ja900371q
Synthesis of anhydride precursors of the environment-sensitive fluorophores 4-dmap and 6-dmn
Matthieu Sainlos, Barbara Imperiali.
Nat Protoc. 2007-12-01. 2(12) : 3219-3225.
10.1038/nprot.2007.444
Tools for investigating peptide-protein interactions: Peptide incorporation of environment-sensitive fluorophores through spps-based ‘building block’ approach
Matthieu Sainlos, Barbara Imperiali.
Nat Protoc. 2007-12-01. 2(12) : 3210-3218.
10.1038/nprot.2007.443
Tools for investigating peptide-protein interactions: Peptide incorporation of environment-sensitive fluorophores via on-resin derivatization
Matthieu Sainlos, Barbara Imperiali.
Nat Protoc. 2007-12-01. 2(12) : 3201-3209.
10.1038/nprot.2007.442
Self-assembled lamellar complexes of siRNA with lipidic aminoglycoside derivatives promote efficient siRNA delivery and interference
L. Desigaux, M. Sainlos, O. Lambert, R. Chevre, E. Letrou-Bonneval, J.-P. Vigneron, P. Lehn, J.-M. Lehn, B. Pitard.
Proceedings of the National Academy of Sciences. 2007-10-08. 104(42) : 16534-16539.
10.1073/pnas.0707431104
Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells
Prasanna Venkatraman, Tina T Nguyen, Matthieu Sainlos, Osman Bilsel, Sriram Chitta, Barbara Imperiali, Lawrence J Stern.
Nat Chem Biol. 2007-03-11. 3(4) : 222-228.
10.1038/nchembio868
Aminoglycoside-quinacridine conjugates: Towards recognition of the P6.1 element of telomerase RNA
Markus Kaiser, Matthieu Sainlos, Jean-Marie Lehn, Sophie Bombard, Marie-Paule Teulade-Fichou.
ChemBioChem. 2006-01-12. 7(2) : 321-329.
10.1002/cbic.200500354
Neomycin-capped aromatic platforms: Quadruplex DNA recognition and telomerase inhibition
Markus Kaiser, Anne De Cian, Matthieu Sainlos, Christian Renner, Jean-Louis Mergny, Marie-Paule Teulade-Fichou.
Org. Biomol. Chem.. 2006-01-01. 4(6) : 1049.
10.1039/b516378a
Kanamycin A-derived cationic lipids as vectors for gene transfection
Matthieu Sainlos, Michelle Hauchecorne, Noufissa Oudrhiri, Samia Zertal-Zidani, Abderrahim Aissaoui, Jean-Pierre Vigneron, Jean-Marie Lehn, Pierre Lehn.
ChemBioChem. 2005-05-10. 6(6) : 1023-1033.
10.1002/cbic.200400344
The design of cationic lipids for gene delivery
B. Martin, M. Sainlos, A. Aissaoui, N. Oudrhiri, M. Hauchecorne, J.- Vigneron, J.- Lehn, P. Lehn.
CPD. 2005-02-01. 11(3) : 375-394.
10.2174/1381612053382133
Aminoglycoside-derived cationic lipids for gene transfection: Synthesis of kanamycin A derivatives
Matthieu Sainlos, Philippe Belmont, Jean-Pierre Vigneron, Pierre Lehn, Jean-Marie Lehn.
Eur. J. Org. Chem.. 2003-08-01. 2003(15) : 2764-2774.
10.1002/ejoc.200300164
Progress in gene delivery by cationic lipids: Guanidinium-cholesterol based systems as an example
Abderrahim Aissaoui, Noufissa Oudrhiri, Laure Petit, Michelle Hauchecorne, Erwan Kan, Matthieu Sainlos, Sebastien Julia, Jean Navarro, Jean-Pierre Vigneron, Jean-Marie Lehn.
CDT. 2002-02-01. 3(1)
10.2174/1389450023348082