Chargement Évènements

« Tous les Évènements

  • Cet évènement est passé

Séminaire – Stéphanie Trouche

10 mai 2019 / 11:30 - 12:30

Lieu : CGFB / Salle de conférence

Stéphanie Trouche
Stéphanie Trouche


Animals must retrieve memories of food-predicting environments and direct their spatial behaviour to ensure their survival. In mammals, pyramidal cells of the dorsal hippocampus provide a map-like representation of space. How these representations influence the behavioural expression of spatial appetitive memory is still unknown. Our latest work addresses this question by monitoring and manipulating neuronal ensembles from the dorsal hippocampus and the nucleus accumbens in behaving mice. I will present recent evidence showing a functional dissociation between the neuronal reinstatement of a memory and its behavioural manifestation, often assumed to be the same process. We found that hippocampal representations of space are indeed necessary, but not sufficient, to act on appetitive memory retrieval. I will also present mechanistic evidence showing the importance of a tripartite neuronal motif in the dorsal hippocampus-accumbens pathway for successful place-reward behavior.

Selected publications

Trouche, S., Koren, V., Doig, N. M., Ellender, T. J., El-Gaby, M., Lopes-Dos-Santos, V., Reeve, H. M., Perestenko, P. V., Garas, F. N., Magill, P. J., Sharott, A., & Dupret, D. (2019). A Hippocampus-Accumbens Tripartite Neuronal Motif Guides Appetitive Memory in Space. Cell, 176, 1393-1406 e1316.

van de Ven, G. M., Trouche, S., McNamara, C. G., Allen, K., & Dupret, D. (2016). Hippocampal Offline Reactivation Consolidates Recently Formed Cell Assembly Patterns during Sharp Wave-Ripples. Neuron, 92, 968-974.

Trouche, S., Perestenko, P. V., van de Ven, G. M., Bratley, C. T., McNamara, C. G., Campo-Urriza, N., Black, S. L., Reijmers, L. G., & Dupret, D. (2016). Recoding a cocaine-place memory engram to a neutral engram in the hippocampus. Nat Neurosci, 19, 564-567.

Trouche, S., Sasaki, J. M., Tu, T., & Reijmers, L. G. (2013). Fear extinction causes target-specific remodeling of perisomatic inhibitory synapses. Neuron, 80, 1054-1065.

Trouche, S., Bontempi, B., Roullet, P., & Rampon, C. (2009). Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory. Proc Natl Acad Sci U S A, 106, 5919-5924.


Tous les événements

Voir la liste des événements à venir

Voir le calendrier

Notre newsletter

Pour ne rien manquer !


Date :
10 mai 2019
Heure :
11:30 - 12:30
Catégorie d’Évènement: