Olfactory markers in depression
Neurocentre Magendie, Salle de conférence
UMR 1253, iBrain, Université de Tours, Inserm, Tours, France
Clinique Psychiatrique Universitaire, CHRU de Tours, Tours, France
CIC 1415, Inserm, CHRU de Tours, Tours, France
Centre Régional de Psychotraumatologie CVL, CHRU de Tours, Tours, France
Invité par : Pr. Bruno Aouizerate, Dr. Cyril Herry
Olfactory dysfunctions have been described in different psychiatric disorders. Studies report abnormal olfactory perception in depressed patients, whom principally exhibit a deficit in the hedonic aspects of this perception, even if, in some case, alterations in sensitivity or identification are also found. Changes in odor perception are also found in dementia and in some neurodegenerative disease, but in this case alterations concern all aspects of the sensorial experience (detection threshold, identification and recognition). These data indicate that olfactory abnormalities might be a marker of psychiatric conditions, with a specific pattern for each disease. For instance, olfactory dysfunction may be a sensory marker in unipolar and bipolar depression. Olfactory markers of depression can be either state (present only in symptomatic phases) or trait (persistent after symptomatic remission) markers. In this comprehensive conference, we will present data on olfactory parameters (i.e., odor threshold, odor identification, discrimination, intensity, familiarity and pleasantness) in depression and new data on sensory olfactory markers differentiating between unipolar and bipolar depression.
Keywords: Unipolar, Bipolar, Depression, Olfaction, Marker, Threshold, Identification.