Venue: Centre Broca
Organizers
– Andreas Bikfalvi (BRIC)
– Valentin Nägerl (Neurocampus)
About the conference
Glioblastoma (GB) is the most aggressive brain tumor characterized by high proliferation rate, core necrosis, microvascular proliferation and tumor infiltration. GB treatment consists in tumor resection by surgery and radiotherapy plus concomitant chemotherapy with temozolomide (Stupp et al, 2005). However, GB still remains incurable with a low median survival rate of approx. 15 months. This is due to resistance to treatment mainly caused by the presence of tumor cells that escape tumor resection by invading the normal brain parenchyma. Recent developments in immunotherapy did not succeed in overcoming this challenge. Unfortunately, the mechanisms underlying GB development are still not fully understood and current model systems addressing these questions are not adequate, impeding progress for the field. It has been shown that the tumor microenvironment (TME) in GB partially controls tumor growth and invasion, and constitutes a therapeutic target (Bikfalvi et al, 2022). A body of recent studies points to an important role of the normal neuronal brain environment in GB progression. This meeting brings people together from both, the neuro-oncology and neuroscience communities to highlight these new developments occurring at the interface between neuro-oncology and the neurosciences.
Programme
Day 1 – Monday, December 9th
12h30-13h15
Welcome – Registration, attachment posters
14h00-14h45
Introductory remarks and welcome by local Organizing committee
- Challenges in brain tumor research: focus on the tumor microenvironment, Andreas Bikfalvi (BRIC, Bordeaux)
- Structuration de la neuro-oncologie en France, (François Ducray, President de l’ANOCEF)
- The Neurocampus Bordeaux, new directions for interdisciplinary research, Laurent Groc (IINS)
Session 1: Neuroscience and Neuro-Oncology
14h45-15h15
Frank Winkler (DKFZ Heidelberg, DE) – The field of Cancer Neuroscience
15h15-15h45
Valentin Nägerl (IINS, Bordeaux) – Neurophotonics and neuro-oncology
15h45-16h15
Thomas Mathivet (BRIC, Bordeaux) – Imaging the brain tumor vasculature
16h15-17h00 : Coffee Break / Poster Session
17h00-17h30
Giovanni Marsicano (IINS, Bordeaux) – Cannabinoids cannabinoid receptors in the brain
17h30-18h00
Gilles Hueberfeld (IPNB, Paris) – Neuronal control of brain tumors
18h00-18h30
Hélène Castel (INSERM, Rouen) – Cancer related cognitive impairment
18h30 – 19h30 : Wine tasting / Poster Session
Day 2 –Tuesday December 10th
Session 2: Glioblastoma: molecular and mechanistic aspects
09h00-09h30
Marie Pierre Junier (IBPS, Paris) – Plasticity of glioblastoma cells and its vulnerabilities
09h30-10h00
Thomas Daubon (IBGC, Bordeaux) – The lactate cross talk between brain tumors and the nervous system
10h00-10h30
Lucie Brisson (BRIC, Bordeaux) – Autophagy, Lipophagy in glioblastoma, how does this impact on the GB
10h30-11h00 : Coffee Break / Poster Session
11h00-11h30
Ahmad Charanek (BRIC, Bordeaux) – Mitochondria in glioblastoma development
11h30-12h00
Anne-Karine Bouzier-Sore (CRMSB, Bordeaux) – Metabolic interactions in the brain microenvironment
12h00-12h30
Grégory Giannone (IINS, Bordeaux) – Deciphering mechano-biology using super-resolution microscopy
12h30-14h30 : Lunch buffet / Poster Session
Session 3: Diffuse IDH1 mutant gliomas
14h30-15h00
Marc Sanson (ICM, Paris) – New insight’s into the biology of IDH mutant gliomas, therapeutic implications
15H00 -15H30
Christèle Etchegaray (INRIA, Bordeaux) & Andreas Bikfalvi (BRIC, Bordeaux) – Multiparametric analysis of IDH-mutant gliomas
15h30 -16H00
François Ducray (CRCL, Lyon) – Oligodendrogliomas : clinical challenges and new insights from multi-omic studies
16h00-16h30 : Coffee Break / Poster Session
Lecture Magistralis:
16h30-17h15
Michelle Monje (Stanford, USA) – Cancer Neuroscience and Pediatric Gliomas
17h15- 17h30 : Poster Awards
Round table discussion:
17h30-18H15
Andreas Bikfalvi, Francois Ducray, Valentin Nägerl, Marc Sanson, Frank Winkler – How Neuroscience and Neuro-oncology can cross-fertilize each other & the place of a Bordeaux Cancer Neuroscience initiative in this context
18h15- 18h30 : Congress closing speech