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Impromptu seminar – Erdem Karatekin

21 juin 2022 / 11:30

Erdem Karatekin

Assistant Professor
Department of Cellular and Molecular Physiology,
School of Medicine, and the Nanobiology Institute
Yale University, USA
Lab webpage

Venue: Centre Broca


Dynamics of cell membrane tension and vesicle recycling


Many cellular activities, such as cell migration, cell division, phagocytosis, and exo-endocytosis, generate and are regulated by membrane tension gradients. Membrane tension gradients drive membrane flows, but there is controversy over how rapidly plasma membrane flow can relax tension gradients. Here we show that membrane tension can propagate rapidly or slowly, spanning orders of magnitude in speed, depending on cell type. In a neuronal terminal specialized for rapid synaptic vesicle turnover, membrane tension equilibrates within seconds. By contrast, membrane tension does not propagate in neuroendocrine adrenal chromaffin cells secreting catecholamines. Stimulation of exocytosis causes a rapid, global decrease in the synaptic terminal membrane tension, which recovers slowly due to endocytosis. Thus, membrane flow and tension equilibration may be adapted to distinct membrane recycling requirements.

Recent references

– Gomis Perez et al. Science Advances, 2022; Vol 8(1), DOI:

– Wu et al., eLife 2021;10:e68215. DOI:

For more information

Lab webpage

Invited by David Perrais (IINS)

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Date :
21 juin 2022
Heure :
Catégories d’Évènement:
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