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X-WR-CALNAME:Bordeaux Neurocampus
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X-WR-CALDESC:Évènements pour Bordeaux Neurocampus
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DTSTART:20220327T010000
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DTSTART;TZID=Europe/Paris:20220621T113000
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DTSTAMP:20260409T030514
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UID:148037-1655811000-1655811000@www.bordeaux-neurocampus.fr
SUMMARY:Impromptu seminar - Erdem Karatekin
DESCRIPTION:\nErdem Karatekin\nAssistant Professor\nDepartment of Cellular and Molecular Physiology\,\nSchool of Medicine\, and the Nanobiology Institute\nYale University\, USA\nLab webpage\nVenue: Centre Broca\nTitle\nDynamics of cell membrane tension and vesicle recycling \nAbstract\nMany cellular activities\, such as cell migration\, cell division\, phagocytosis\, and exo-endocytosis\, generate and are regulated by membrane tension gradients. Membrane tension gradients drive membrane flows\, but there is controversy over how rapidly plasma membrane flow can relax tension gradients. Here we show that membrane tension can propagate rapidly or slowly\, spanning orders of magnitude in speed\, depending on cell type. In a neuronal terminal specialized for rapid synaptic vesicle turnover\, membrane tension equilibrates within seconds. By contrast\, membrane tension does not propagate in neuroendocrine adrenal chromaffin cells secreting catecholamines. Stimulation of exocytosis causes a rapid\, global decrease in the synaptic terminal membrane tension\, which recovers slowly due to endocytosis. Thus\, membrane flow and tension equilibration may be adapted to distinct membrane recycling requirements. \nRecent references\n– Gomis Perez et al. Science Advances\, 2022; Vol 8(1)\, DOI: https://www.doi.org/10.1126/sciadv.abl4411 \n– Wu et al.\, eLife 2021;10:e68215. DOI: https://doi.org/10.7554/eLife.68215. \nFor more information\nLab webpage \n\nInvited by David Perrais (IINS) \n
URL:https://www.bordeaux-neurocampus.fr/event/impromptu-seminar-erdem-karatekin/
CATEGORIES:A la une,Pour les scientifiques,Séminaire Impromptu
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