Synapse in cognition
Synapses are plastic. They change their efficacy depending on various parameters, including the respective activities of pre- and post-synaptic neurons. Numerous in vitro studies explored the plasticity repertoire of numerous synaptic populations in the mouse brain, but more rarely with regards to their endogenous inducers. It is no doubt that synaptic plasticity is associated and mediates learning and memory, thus our goal is to identify the neuronal activities that are associated with the learning and execution of cognitive abilities, and to understand how, when and where synaptic plasticity is generated. We are developing cooperative in vivo and in vitro strategies to study the link between synapse and cognition. These include behavioral tests, in vivo pharmacology and optogenetic, and in vitro electrophysiological recording in various brain regions of identified synaptic populations. Future projects will focus on various aspects of spatial learning, and will more and more includes in vivo electrophysiological recordings in freely behaving mice. Ex. Our main objective is to understand the link between synapse and cognition at the synaptic and circuit level. Our recent results show that several mental retardation (MR) mouse models exhibit functional synaptic deficits at cortical projections to the lateral amygdala (LA), a structure involved in the coding of fear memory. We will examine the role of MR proteins in the process of memory formation by analysing biochemical, morphological and physiological changes of cortico-LA synapses in mice submitted to fear conditioning.
Innovative techniques: In vivo electrophysiology, in vivo two-photon imaging of neuronal activity, fluorescence-activated sorting of synaptosomes
Mots clésApprentissage, Assemblées neuronales, Codage et intégration du signal, Cognition, Connectivité, Formation et fonctionnement des circuits neuronaux, Mémoire, Neurophysiologie, Optogénétique, Physiologie synaptique, Plasticité des réseaux, Plasticité synaptique, Sommeil - Troubles du sommeil
- The next generation of approaches to investigate the link between synaptic plasticity and learning. Yann Humeau, Daniel Choquet. Nat Neurosci. 2019-09-02. 22 (10) : 1536-1543.
- Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models. Hongyu Zhang, Chunlei Zhang, Jean Vincent, Diana Zala, Caroline Benstaali, Matthieu Sainlos, Dolors Grillo-Bosch, Sophie Daburon, Françoise Coussen, Yoon Cho, Denis J. David, Frederic Saudou, Yann Humeau, Daniel Choquet. Nat Commun. 2018-10-15. 9 (1)
- Protein Kinase A deregulation in the medial prefrontal cortex impairs working memory in murine Oligophrenin1 deficiency. Chun-Lei Zhang, Mattia Aime, Emilie Laheranne, Xander Houbaert, Hajer El Oussini, Christelle Martin, Marilyn Lepleux, Elisabeth Normand, Jamel Chelly, Etienne Herzog, Pierre Billuart, Yann Humeau. J. Neurosci.. 2017-10-13. 37 (46) : 11114-11126.
- Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors.. A. C. Penn, C. L. Zhang, F. Georges, L. Royer, C. Breillat, E. Hosy, J. D. Petersen, Y. Humeau, D. Choquet. Nature. 2017-09-13. 549 (7672) : 384-388.
- Profiling olfactory stem cells from living patients identifies miRNAs relevant for autism pathophysiology.. Nguyen LS, Lepleux M, Makhlouf M, Martin C, Fregeac J, Siquier-Pernet K, Philippe A, Feron F, Gepner B, Rougeulle C, Humeau Y, Colleaux L. Mol Autism.. 2016-01-08. 7 (1)
Yann Humeau Humeau (Team leader)
Chercheurs, Praticiens hospitaliers...
IINS - UMR 5297 - CNRS - Université de Bordeaux - Centre Broca Nouvelle-Aquitaine - 146 rue Léo-Saignat - CS 61292 CASE 130 - 33076 Bordeaux cedex -France