Structural biology and engineering of neuronal signalling


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The interests of our team lay at the interface of structural biology, protein engineering, and cellular neuroscience. We aim to understand molecular principles of neuronal signalling in health and disease, and to translate these to the cellular and organismal level.

We use mammalian protein expression, protein chemistry, biophysical methods, X-ray crystallography and cryo-electron microscopy to study the interaction determinants and structures of synaptic protein complexes involved in neurodevelopmental disorders and neuronal disease. We use combinatorial methods and protein engineering to discover novel binders and manipulate protein sequence, structure and function, both to facilitate structural studies as well as enable therapeutic targeting of these complexes.

Selected publications

Team leader
Jonathan Elegheert

Team member(s)

Chercheurs, Praticiens hospitaliers...

Ingénieur(e)s, technicien(ne)s

Adrien Doridant


Ester Behiels
Steven De Munck


Neuropsychologist(s) and speech therapist(s)

Ingénieur(s) hospitalier(s) et ARC