Purinergic mediated neuroinflammation and brain disorders
Neurological disorders rely on alterations of the central or peripheral nervous system that are caused by impairments of neuronal transmission or more global perturbations of local circuits that implicate glial cells. The scientific goal of our team is to understand the contribution of neuronal versus inflammatory signaling in brain disorders including amyotrophic lateral sclerosis (ALS), attention deficit/hyperactivity disorders (ADHD), chronic pain, and anxiety-related disorders. Our objectives are to determine (i) the contribution of purinergic signaling as a dual system, and (ii) the modulatory function of peptidergic signaling, both capable to regulate neuronal synaptic activation and microglial neuro-inflammatory reaction as well as developmental processes. We combine cellular, anatomical, functional and behavioral approaches from in vitro to animal models. We expect to reveal the respective contribution of neuronal versus inflammation signaling in several central disorders and to provide attractive novel strategies and cellular targets to cure these disorders.
Mots clés
ADHD (attention-deficit hyperactivity disorder), Anxiété, Douleur, Dépression, Développement du système nerveux, Interactions neurones-glie, Motricité, Optogénétique, Plasticité synaptique, Sclérose latérale amyotrophique, Signalisation, Ultrastructure neuronale et morphogénèseSelected publications
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Increased surface P2X4 receptors by mutant SOD1 proteins contribute to ALS pathogenesis in SOD1-G93A mice.
Eléonore Bertin, Audrey Martinez, Anne Fayoux, Kevin Carvalho, Sara Carracedo, Pierre-Olivier Fernagut, Friedrich Koch-Nolte, David Blum, Sandrine S. Bertrand, Eric Boué-Grabot.
Cell. Mol. Life Sci.. 2022-07-19. 79 (8)
DOI: 10.1007/s00018-022-04461-5 -
Pain hypersensitivity in a pharmacological mouse model of attention-deficit/hyperactivity disorder..
Otmane Bouchatta, Franck Aby, Wahiba Sifeddine, Rabia Bouali-Benazzouz, Louison Brochoire, Houria Manouze, Pascal Fossat, Saadia Ba M’Hamed, Mohamed Bennis, Marc Landry.
Proc. Natl. Acad. Sci. U.S.A.. 2022-07-19. 119 (30)
DOI: 10.1073/pnas.2114094119 -
Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders.
Alexia Duveau, Eléonore Bertin, Eric Boué-Grabot.
Neurosci. Bull.. 2020-09-05.
DOI: 10.1007/s12264-020-00570-y -
Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders.
Alexia Duveau, Eléonore Bertin, Eric Boué-Grabot.
Neurosci. Bull.. 2020-09-05.
DOI: 10.1007/s12264-020-00570-y -
Spinal Inhibition of GABAB Receptors by the Extracellular Matrix Protein Fibulin-2 in Neuropathic Rats.
Marie-Amélie Papon, Yves Le Feuvre, Gabriel Barreda-Gómez, Alexandre Favereaux, Fanny Farrugia, Rabia Bouali-Benazzouz, Frédéric Nagy, Rafael Rodríguez-Puertas, Marc Landry.
Front. Cell. Neurosci.. 2020-07-15. 14
DOI: 10.3389/fncel.2020.00214 -
Increased surface P2X4 receptor regulates anxiety and memory in P2X4 internalization-defective knock-in mice.
Eléonore Bertin, Thomas Deluc, Kjara S. Pilch, Audrey Martinez, Johan-Till Pougnet, Evelyne Doudnikoff, Anne-Emilie Allain, Philine Bergmann, Marion Russeau, Estelle Toulmé, Erwan Bezard, Friedrich Koch-Nolte, Philippe Séguéla, Sabine Lévi, Bruno Bontempi, François Georges, Sandrine S. Bertrand, Olivier Nicole, Eric Boué-Grabot.
Mol Psychiatry. 2020-01-08.
DOI: 10.1038/s41380-019-0641-8 -
Comparative Embryonic Spatio-Temporal Expression Profile Map of the Xenopus P2X Receptor Family.
Camille Blanchard, Eric Boué-Grabot, Karine Massé.
Front. Cell. Neurosci.. 2019-07-26. 13
DOI: 10.3389/fncel.2019.00340 -
Acquisition of analgesic properties by the cholecystokinin (CCK)/CCK2 receptor system within the amygdala in a persistent inflammatory pain condition..
Olivier Roca-Lapirot, Pascal Fossat, Sherie Ma, Karine Egron, Gabriella Trigilio, María-José López-González, João Covita, Rabia Bouali-Benazzouz, Alexandre Favereaux, Andrew L. Gundlach, Marc Landry.
PAIN. 2019-02-01. 160 (2) : 345-357.
DOI: 10.1097/j.pain.0000000000001408 -
Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport.
Maria M Magiera, Satish Bodakuntla, Jakub Žiak, Sabrina Lacomme, Patricia Marques Sousa, Sophie Leboucher, Torben J Hausrat, Christophe Bosc, Annie Andrieux, Matthias Kneussel, Marc Landry, André Calas, Martin Balastik, Carsten Janke.
EMBO J. 2018-11-12. 37 (23)
DOI: 10.15252/embj.2018100440 -
Neonatal 6-OHDA lesion model in mouse induces Attention-Deficit/ Hyperactivity Disorder (ADHD)-like behaviour.
Otmane Bouchatta, Houria Manouze, Rabia Bouali-benazzouz, Nóra Kerekes, Saadia Ba-M’hamed, Pascal Fossat, Marc Landry, Mohamed Bennis.
Sci Rep. 2018-10-18. 8 (1)
DOI: 10.1038/s41598-018-33778-0 -
APE1/Ref-1 redox function contributes to inflammatory pain sensitization..
Amira Zaky, Rabia Bouali-Benazzouz, Alexandre Favereaux, Gianluca Tell, Marc Landry.
Experimental Neurology. 2018-09-01. 307 : 1-11.
DOI: 10.1016/j.expneurol.2018.05.014 -
MicroRNA and chronic pain: From mechanisms to therapeutic potential..
María José López-González, Marc Landry, Alexandre Favereaux.
Pharmacology & Therapeutics. 2017-12-01. 180 : 1-15.
DOI: 10.1016/j.pharmthera.2017.06.001 -
Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors.
Eric Boué-Grabot, Yuriy Pankratov.
Neural Plasticity. 2017-01-01. 2017 : 1-11.
DOI: 10.1155/2017/9454275 -
Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation..
W. Danquah, C. Meyer-Schwesinger, B. Rissiek, C. Pinto, A. Serracant-Prat, M. Amadi, D. Iacenda, J.-H. Knop, A. Hammel, P. Bergmann, N. Schwarz, J. Assuncao, W. Rotthier, F. Haag, E. Tolosa, P. Bannas, E. Boue-Grabot, T. Magnus, T. Laeremans, C. Stortelers, F. Koch-Nolte.
Science Translational Medicine. 2016-11-23. 8 (366) : 366ra162-366ra162.
DOI: 10.1126/scitranslmed.aaf8463 -
P2X-mediated AMPA receptor internalization and synaptic depression is controlled by two CaMKII phosphorylation sites on GluA1 in hippocampal neurons.
Johan-Till Pougnet, Benjamin Compans, Audrey Martinez, Daniel Choquet, Eric Hosy, Eric Boué-Grabot.
Sci Rep. 2016-09-01. 6 (1)
DOI: 10.1038/srep31836 -
Cav1.2 and Cav1.3 L-type calcium channels independently control short- and long-term sensitization to pain..
Houda Radwani, Maria José Lopez-Gonzalez, Daniel Cattaert, Olivier Roca-Lapirot, Eric Dobremez, Rabia Bouali-Benazzouz, Emelía Eiríksdóttir, Ülo Langel, Alexandre Favereaux, Mohammed Errami, Marc Landry, Pascal Fossat.
J Physiol. 2016-07-03. 594 (22) : 6607-6626.
DOI: 10.1113/jp272725 -
Selective Inactivation of Striatal FosB/ΔFosB-Expressing Neurons Alleviates L-DOPA-Induced Dyskinesia..
Michel Engeln, Matthieu F. Bastide, Estelle Toulmé, Benjamin Dehay, Mathieu Bourdenx, Evelyne Doudnikoff, Qin Li, Christian E. Gross, Eric Boué-Grabot, Antonio Pisani, Erwan Bezard, Pierre-Olivier Fernagut.
Biological Psychiatry. 2016-03-01. 79 (5) : 354-361.
DOI: 10.1016/j.biopsych.2014.07.007 -
A New Mechanism of Receptor Targeting by Interaction between Two Classes of Ligand-Gated Ion Channels.
Michel Boris Emerit, Camille Baranowski, Jorge Diaz, Audrey Martinez, Julie Areias, Jeanine Alterio, Justine Masson, Eric Boué-Grabot, Michèle Darmon.
J. Neurosci.. 2016-02-03. 36 (5) : 1456-1470.
DOI: 10.1523/JNEUROSCI.2390-15.2016 -
A secretagogin locus of the mammalian hypothalamus controls stress hormone release.
Roman A Romanov, Alán Alpár, Ming‐Dong Zhang, Amit Zeisel, André Calas, Marc Landry, Matthew Fuszard, Sally L Shirran, Robert Schnell, Árpád Dobolyi, Márk Oláh, Lauren Spence, Jan Mulder, Henrik Martens, Miklós Palkovits, Mathias Uhlen, Harald H Sitte, Catherine H Botting, Ludwig Wagner, Sten Linnarsson, Tomas Hökfelt, Tibor Harkany.
EMBO J. 2014-11-27. 34 (1) : 36-54.
DOI: 10.15252/embj.201488977 -
ATP P2X receptors downregulate AMPA receptor trafficking and postsynaptic efficacy in hippocampal neurons..
Johan-Till Pougnet, Estelle Toulme, Audrey Martinez, Daniel Choquet, Eric Hosy, Eric Boué-Grabot.
Neuron. 2014-07-01. 83 (2) : 417-430.
DOI: 10.1016/j.neuron.2014.06.005
Team leader
Eric Boué-Grabot Boué-Grabot (Team leader - Deputy director of IMN)
Marc Landry Landry (Team leader - BIC Deputy platform leader)
Team member(s)
Eric Boué-Grabot Boué-Grabot (Team leader - Deputy director of IMN)
Marc Landry Landry (Team leader - BIC Deputy platform leader)
Chercheurs, Praticiens hospitaliers...
André Calas
Calas
(University teacher-researcher)
Karine Massé Massé (University Teacher- Researcher)
Karine Massé Massé (University Teacher- Researcher)
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Cynthia Khoury Abboud
Khoury Abboud
Doctorant(s)