Pathophysiology of declarative memory
Our aim is to identify psychobiological bases of declarative memory (DM) alterations occurring in aging and post-traumatic stress disorder (PTSD). We have developed specific behavioral models of age- and PTSD-related memory alterations in the mouse. Using these models, we search correlates of the cognitive changes at the system, cellular and molecular levels of brain activities. To establish causality links between neurobiological and cognitive changes, we then combine interventional approaches with pharmacological tools/optogenetics to our behavioral testing.
Innovative techniques:
1) Behavior:
– radial-maze models of age-related decline of declarative memory in mice, successfully translated to humans using virtual radial-maze
– the first model assessing qualitative features distinguishing normal/adaptive and maladaptive fear memory characteristic of PTSD in mice
2) Optogenetic/intracerebral infusion of drugs in behaving mice
Mots clés
Apprentissage, Cognition, Emotion, Mémoire, Stress, TSPT (Troubles de stress post-traumatique), Troubles anxieux, interactions neuro-vasculairesSelected publications
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Age-related impairment of declarative memory: linking memorization of temporal associations to GluN2B redistribution in dorsal CA1.
l Abed AS, Sellami A, Potier M, Ducourneau EG, Gerbeaud-Lassau P, Brayda-Bruno L, Lamothe V, Sans N, Desmedt A, Vanhoutte P, Bennetau-Pelissero C, Trifilieff P, Marighetto A..
Aging Cell. 2020 Oct 3. 19 (10) : e13243.
DOI: 10.1111/acel.13243 -
Preventing and treating PTSD-like memory by trauma contextualization
Alice Shaam Al Abed, Eva-Gunnel Ducourneau, Chloé Bouarab, Azza Sellami, Aline Marighetto, Aline Desmedt.
Nat Commun. 2020-08-24. 11 (1) : 4220.
DOI: 10.1038/s41467-020-18002-w. -
Brexpiprazole blocks post-traumatic stress disorder-like memory while promoting normal fear memory
Eva-Gunnel Ducourneau, Christelle Guette, Damien Perrot, Miguel Mondesir, Cédric Mombereau, Jorn Arnt, Aline Desmedt & Pier-Vincenzo Piazza.
Molecular Psychiatry. 2020-08-19.
DOI: 10.1038/s41380-020-0852-z -
False Opposing Fear Memories Are Produced as a Function of the Hippocampal Sector Where Glucocorticoid Receptors Are Activated
Nadia Kaouane, Eva-Gunnel Ducourneau, Aline Marighetto, Menahem Segal, Aline Desmedt.
Front. Behav. Neurosci. 2020-08-26.
DOI: 10.3389/fnbeh.2020.00144 -
Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion
Benjamin J.A. Robert, Maïté M. Moreau, Steve Dos Santos Carvalho, Gael Barthet, Claudia Racca, Mehdi Bhouri, Anne Quiedeville, Maurice Garret, Bénédicte Atchama, Alice Shaam Al Abed, Christelle Guette, Deborah J. Henderson, Aline Desmedt, Christophe Mulle, Aline Marighetto, Mireille Montcouquiol, Nathalie Sans.
Cell Reports. 2020-06-01. 31 (10) : 107743.
DOI: 10.1016/j.celrep.2020.107743 -
BDNF-TrkB signaling through Erk1/2MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids
J-M Revest, A Le Roux, V Roullot-Lacarrière, N Kaouane, M Vallée, F Kasanetz, F Rougé-Pont, F Tronche, A Desmedt & P V Piazza.
Molecular Psychiatry. . 19 : 1001–1009.
DOI: 10.1038/mp.2013.134 -
The enhancement of stress-related memory by glucocorticoids depends on synapsin-Ia/Ib.
JM Revest, N Kaouane, M Mondin, A Le Roux, F Rougé-Pont, M Vallée, J Barik, F Tronche, A Desmedt and P V Piazza..
Molecular Psychiatry. 2010-4-6. 15 (12) : 1140-1151.
DOI: 10.1038/mp.2010.40 -
Temporal binding function of dorsal CA1 is critical for declarative memory formation
Azza Sellami, Alice Shaam Al Abed, Laurent Brayda-Bruno, Nicole Etchamendy, Stéphane Valério, Marie Oulé, Laura Pantaléon, Valérie Lamothe, Mylène Potier, Katy Bernard, Maritza Jabourian, Cyril Herry, Nicole Mons, Pier-Vincenzo Piazza, Howard Eichenbaum, Aline Marighetto.
Proc Natl Acad Sci USA. 2017-09-05. 114 (38) : 10262-10267.
DOI: 10.1073/pnas.1619657114 -
Estradiol enhances retention but not organization of hippocampus-dependent memory in intact male mice
Alice Shaam Al Abed, Azza Sellami, Laurent Brayda-Bruno, Valérie Lamothe, Xavier Noguès, Mylène Potier, Catherine Bennetau-Pelissero, Aline Marighetto.
Psychoneuroendocrinology. 2016-07-01. 69 : 77-89.
DOI: 10.1016/j.psyneuen.2016.03.014 -
Temporal Memory and Its Enhancement by Estradiol Requires Surface Dynamics of Hippocampal CA1 N-Methyl-D-Aspartate Receptors
Mylène Potier, François Georges, Laurent Brayda-Bruno, Laurent Ladépêche, Valérie Lamothe, Alice Shaam Al Abed, Laurent Groc, Aline Marighetto.
Biological Psychiatry. 2016-05-01. 79 (9) : 735-745.
DOI: 10.1016/j.biopsych.2015.07.017 -
Abnormal Fear Memory as a Model for Posttraumatic Stress Disorder
Aline Desmedt, Aline Marighetto, Pier-Vincenzo Piazza.
Biological Psychiatry. 2015-09-01. 78 (5) : 290-297.
DOI: 10.1016/j.biopsych.2015.06.017 -
Glucocorticoids can induce PTSD-like memory impairments in mice
N. Kaouane, Y. Porte, M. Vallee, L. Brayda-Bruno, N. Mons, L. Calandreau, A. Marighetto, P. V. Piazza, A. Desmedt.
Science. 2012-02-23. 335 (6075) : 1510-1513.
DOI: 10.1126/science.1207615
Team member(s)
Chercheurs, Praticiens hospitaliers...
Nicole Etchamendy Etchamendy (University Teacher- Researcher)
Sophie Tronel Tronel (Researcher)
Nathalie Macrez Macrez (Researcher)
Jacques Micheau Micheau (University Teacher- Researcher)
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Doctorant(s)
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC