Molecular Dynamics of the Synapse (DynamicSyn)
We study the dynamic composition of synapses, the molecular basis of memory encoding in the brain. My lab uses omics-approaches combined with FACs-based synapse purification, metabolic labelling, super-resolution, and live-imaging as well as computational modelling to elucidate changes in synapse composition associated with learning, aging and diseases. We aim for a better understanding of synaptic to help the development of innovative preventive and therapeutic approaches to brain dysfunction. In 2022, I received an ERC Starting Grant from the European Research Council for my project MemCode, to investigate the mechanisms of long-term memory storage in the brain; and in 2026 an ERC Proof of Concept to test a gene therapy to stop Alzheimer’s disease progression at early stages.
The 3 main research topics are Etiology of memory , Elucidating molecular memory traces and Molecular mechanisms of synaptopathies .
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Team member(s)
Chercheurs, Praticiens hospitaliers...
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Doctorant(s)
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC