IMN clinics
The clinical branch of the Institute of Neurodegenerative Diseases (IMNc) combines patient care (Expert Center for Parkinson’s disease, Dementia Clinic, French Reference Centre for Multiple System Atrophy, Competence Centre for Rare Dementia, Competence Centre for Tourette Syndrome) and clinical research in the fields of neurodegenerative diseases and movement disorders. Our research program builds on three axes. The first research axis investigates the pathophysiology of movement disorders and neurodegenerative diseases, focusing on dystonia, Tourette syndrome, gait, and tremor using both imaging and electrophysiological technics. The second research axis investigates the natural history of neurodegenerative disorders. It aims to determine factors of prognosis, survival, and health-related quality of life and identify potential diagnosis and prognosis biomarkers by taking advantage of several well-characterized prospective clinical cohorts. The third research axis capitalizes upon the long-standing expertise of IMNc investigators in clinical trials. This research axis emphasizes the refinement of clinical assessment tools and the development of diagnosis and prognosis biomarkers. The investigators of the IMNc research team lead or contribute to numerous academic and industry-sponsored multi-center trials. Also, the team focuses on complementary medicine and developing non-pharmacological interventions (mindfulness, psychosocial support, and care by specialized teams).
Mots clés
Alzheimer, Atrophie multi-systématisée, Biomarqueurs, Cognition, Cohortes, Diagnostic, Dystonie, Démences, Imagerie, Mouvement anormaux, Parkinson, Physiopathologie, Qualité de vie, Recherche clinique, Syndrome de Tourette, Thérapeutique, Thérapies non médicamenteuses complémentaires, TremblementSelected publications
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Multiple system atrophy
Werner Poewe, Iva Stankovic, Glenda Halliday, Wassilios G. Meissner, Gregor K. Wenning, Maria Teresa Pellecchia, Klaus Seppi, Jose-Alberto Palma, Horacio Kaufmann.
Nat Rev Dis Primers. 2022-08-25. 8 (1)
DOI: 10.1038/s41572-022-00382-6 -
Validity and Performance of Blood Biomarkers for Alzheimer Disease to Predict Dementia Risk in a Large Clinic-Based Cohort
Vincent Planche, Vincent Bouteloup, Isabelle Pellegrin, Jean-Francois Mangin, Bruno Dubois, Pierre-Jean Ousset, Florence Pasquier, Frederic Blanc, Claire Paquet, Olivier Hanon, Karim Bennys, Mathieu Ceccaldi, Cédric Annweiler, Pierre Krolak-Salmon, Olivier Godefroy, David Wallon, Mathilde Sauvee, Claire Boutoleau-Bretonnière, Isabelle Bourdel-Marchasson, Isabelle Jalenques, Genevieve Chene, Carole Dufouil,.
Neurology. 2022-10-19. : 10.1212/WNL.0000000000201479.
DOI: 10.1212/wnl.0000000000201479 -
Advocating for Demonstration of Disease Modification—Have We Been Approaching Clinical Trials in Early Alzheimer Disease Incorrectly?
Vincent Planche, Nicolas Villain.
JAMA Neurol. 2023-04-24.
DOI: 10.1001/jamaneurol.2023.0815 -
Clinical relevance of brain atrophy subtypes categorization in memory clinics
Vincent Planche, Vincent Bouteloup, Jean‐François Mangin, Bruno Dubois, Julien Delrieu, Florence Pasquier, Frédéric Blanc, Claire Paquet, Olivier Hanon, Audrey Gabelle, Matthieu Ceccaldi, Cédric Annweiler, Pierre Krolak‐Salmon, Marie‐Odile Habert, Clara Fischer, Marie Chupin, Yannick Béjot, Olivier Godefroy, David Wallon, Mathilde Sauvée, Isabelle Bourdel‐Marchasson, Isabelle Jalenques, François Tison, Geneviève Chêne, Carole Dufouil,.
Alzheimer's & Dementia. 2020-12-15. 17 (4) : 641-652.
DOI: 10.1002/alz.12231 -
Disentangling clinical and biological trajectories of neurodegenerative diseases
Nicolas Villain, Vincent Planche.
Nat Rev Neurol. 2024-08-08.
DOI: 10.1038/s41582-024-01004-3 -
Trial of Lixisenatide in Early Parkinson’s Disease
Wassilios G. Meissner, Philippe Remy, Caroline Giordana, David Maltête, Pascal Derkinderen, Jean-Luc Houéto, Mathieu Anheim, Isabelle Benatru, Thomas Boraud, Christine Brefel-Courbon, Nicolas Carrière, Hélène Catala, Olivier Colin, Jean-Christophe Corvol, Philippe Damier, Estelle Dellapina, David Devos, Sophie Drapier, Margherita Fabbri, Vanessa Ferrier, Alexandra Foubert-Samier, Solène Frismand-Kryloff, Aurore Georget, Christine Germain, Stéphane Grimaldi, Clémence Hardy, Lucie Hopes, Pierre Krystkowiak, Brice Laurens, Romain Lefaucheur, Louise-Laure Mariani, Ana Marques, Claire Marse, Fabienne Ory-Magne, Vincent Rigalleau, Hayet Salhi, Amandine Saubion, Simon R. W. Stott, Claire Thalamas, Claire Thiriez, Mélissa Tir, Richard K. Wyse, Antoine Benard, Olivier Rascol.
N Engl J Med. 2024-04-04. 390 (13) : 1176-1185.
DOI: 10.1056/NEJMoa2312323 -
Patient-perceived progression in multiple system atrophy: natural history of quality of life
Tiphaine Saulnier, Margherita Fabbri, Mélanie Le Goff, Catherine Helmer, Anne Pavy-Le Traon, Wassilios G. Meissner, Olivier Rascol, Cecile Proust-Lima, Alexandra Foubert-Samier.
J Neurol Neurosurg Psychiatry. 2024-03-07. : jnnp-2023-332733.
DOI: 10.1136/jnnp-2023-332733 -
Multiple system atrophy
Werner Poewe, Iva Stankovic, Glenda Halliday, Wassilios G. Meissner, Gregor K. Wenning, Maria Teresa Pellecchia, Klaus Seppi, Jose-Alberto Palma, Horacio Kaufmann.
Nat Rev Dis Primers. 2022-08-25. 8 (1)
DOI: 10.1038/s41572-022-00382-6
Team member(s)
Chercheurs, Praticiens hospitaliers...
François Tison Tison (PU-PH)
Nathalie Damon Perrière Damon Perrière (Hospital practitioner)
Thomas Boraud Boraud (Director of IMN)
Pierre Burbaud Burbaud (PU-PH)
Emmanuel Cuny Cuny (University Teacher - Researcher - Hospital practitioner)
Vincent Planche Planche (PU PH)
Dominique Guehl Guehl (University Teacher- Researcher)
Sophie Auriacombe Auriacombe (Hospital Practitionner)
Sylvain Vergnet Vergnet (Hospital practicioner)
Julie Péron-Bonnevaux Péron-Bonnevaux (Physician)
David Bendetowicz Bendetowicz (Praticien hospitalier, post-doctoral Student)
Jade Sarrabere Sarrabere (Cheffe de clinique)
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Doctorant(s)
Neuropsychologist(s) and speech therapist(s)
Nicolas Auzou Auzou (Neuropsychologue)
Marie Bonnet Bonnet (Neuropsychologue)
Isabelle Le Taillandier de Gabory Le Taillandier de Gabory (Speech therapist)
Chloé Lazeras Lazeras (Neuropsychologue)
Chloé Moeyart Moeyart (Neuropsychologist)
Ingénieur(s) hospitalier(s) et ARC
Sandrine Villars Villars (Clinical Research Assistant)
Emmanuelle Durand Durand (Assistant de recherche clinique)
Julie Erraud Erraud (Ingénieur hospitalier / Chef de projet)
Pascale Michel Michel (Assistante de recherche clinique)
Lai Wei Ho Wei Ho (Assistant de recherche clinique)