Dynamic organization and function of synapses
Our team pursues a transdisciplinary approach, to study the interplay between the dynamics of the molecular components of synapses and synaptic transmission. Based on advanced imaging techniques and physiology, we study AMPA receptors and its molecular partners. We obtained breakthrough data on nano-scale organization, dynamics and interaction of synaptic proteins and membrane trafficking. Our efforts are focused on the understanding of the dynamics of synaptic components involved in higher cognitive functions and pathologies, such as Alzheimer disease.
Mots clés
Analyses des données, Bio-senseurs, Biochemistry, Chimie, Imagerie cellulaire in vitro ou in vivo, Microscopie super-résolutive, Optogénétique et chemogénétique, Physiologie synaptique, Signalisation, Synapse molecular complexes, Trafic intracellulaireSelected publications
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Advanced imaging and labelling methods to decipher brain cell organization and function
Daniel Choquet, Matthieu Sainlos, Jean-Baptiste Sibarita.
Nat Rev Neurosci. 2021-03-12.
DOI: 10.1038/s41583-021-00441-z -
A super-resolution platform for correlative live single-molecule imaging and STED microscopy
V. V. G. Krishna Inavalli, Martin O. Lenz, Corey Butler, Julie Angibaud, Benjamin Compans, Florian Levet, Jan Tønnesen, Olivier Rossier, Gregory Giannone, Olivier Thoumine, Eric Hosy, Daniel Choquet, Jean-Baptiste Sibarita, U. Valentin Nägerl.
Nat Methods. 2019-10-21.
DOI: 10.1038/s41592-019-0611-8 -
Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models
Hongyu Zhang, Chunlei Zhang, Jean Vincent, Diana Zala, Caroline Benstaali, Matthieu Sainlos, Dolors Grillo-Bosch, Sophie Daburon, Françoise Coussen, Yoon Cho, Denis J. David, Frederic Saudou, Yann Humeau, Daniel Choquet.
Nat Commun. 2018-10-15. 9 (1)
DOI: 10.1038/s41467-018-06675-3 -
CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity
Patricio Opazo, Silvia Viana da Silva, Mario Carta, Christelle Breillat, Steven J. Coultrap, Dolors Grillo-Bosch, Matthieu Sainlos, Françoise Coussen, K. Ulrich Bayer, Christophe Mulle, Daniel Choquet.
Cell Reports. 2018-06-01. 23 (11) : 3137-3145.
DOI: 10.1016/j.celrep.2018.05.036 -
Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors.
A. C. Penn, C. L. Zhang, F. Georges, L. Royer, C. Breillat, E. Hosy, J. D. Petersen, Y. Humeau, D. Choquet.
Nature. 2017-09-13. 549 (7672) : 384-388.
DOI: 10.1038/nature23658 -
Caged mono- and divalent ligands for light-assisted disruption of PDZ domain-mediated interactions
Matthieu Sainlos, Wendy S. Iskenderian-Epps, Nelson B. Olivier, Daniel Choquet, Barbara Imperiali.
J. Am. Chem. Soc.. 2013-03-13. 135 (12) : 4580-4583.
DOI: 10.1021/ja309870q -
Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization.
Matthieu Sainlos, Cezar Tigaret, Christel Poujol, Nelson B Olivier, Lucie Bard, Christelle Breillat, Kevin Thiolon, Daniel Choquet, Barbara Imperiali.
Nat Chem Biol. 2010-12-26. 7 (2) : 81-91.
DOI: 10.1038/nchembio.498
Team leader
Team member(s)
Chercheurs, Praticiens hospitaliers...
Ingénieur(e)s, technicien(ne)s
Christelle Breillat
Breillat
Nicolas Chevrier Chevrier
Sophie Daburon Daburon
Pauline Belzanne Belzanne
Loris Verron Verron
Nicolas Chevrier Chevrier
Sophie Daburon Daburon
Pauline Belzanne Belzanne
Loris Verron Verron
Post-doctorant(s)
Doctorant(s)
Meera Chandra
Chandra
Manon Darribère Darribere
Chloé Cuenot Cuenot
Léa Sarzynski Sarzynski
Léa Leval Leval
Emma Pessoa Pessoa
Viviana Villacaña-Muñoz Villacaña-Muñoz
Manon Darribère Darribere
Chloé Cuenot Cuenot
Léa Sarzynski Sarzynski
Léa Leval Leval
Emma Pessoa Pessoa
Viviana Villacaña-Muñoz Villacaña-Muñoz
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC