Jean-Christophe Delpech

Scientific articles

• Balanced polyunsaturated fatty acids diet prevents the D-galactose-induced neuroinflammation and cognitive impairments
  Ivan Marniquet, Juliette Dupont-Viratelle, Flavie Crespo, Alexandra Séré, Sophie Layé, Jean-Christophe Delpech.
  Neuroscience Applied. 2026-01-01. 5 : 106989.
  10.1016/j.nsa.2026.106989
• Technical note: Efficient enrichment of plasma-derived extracellular vesicles from small volumes of bovine blood
  Vincent Prieur, Cassar-Malek Isabelle, Delavaud Arnaud, Barry-Carroll Liam, Delpech Jean-Christophe, Morel Isabelle, Lerch Sylvain, Viala Didier, Chennell Philip, Boby Céline, Bonnet Muriel.
  Journal of Animal Science. 2025-10-15.
  10.1093/jas/skaf354
• Rodent models of Alzheimer’s disease: Critical analysis of current hypotheses and pathways for future research
  Pasindu Hansana Singhaarachchi, Peter Antal, Frédéric Calon, Carsten Culmsee, Jean-Christophe Delpech, Martin Feldotto, Jorine Geertsema, Emmy E. Hoeksema, Aniko Korosi, Sophie Layé, Jonathan McQualter, Susanne R. de Rooij, Christoph Rummel, Mary Slayo, Luba Sominsky, Sarah J. Spencer.
  Progress in Neurobiology. 2025-09-01. 252 : 102821.
  10.1016/j.pneurobio.2025.102821
• GLP-1-mediated targeting of inflammation corrects obesogenic memory in male mice
  Stéphane Léon, Julie Benoit, Samantha Clark, Philippe Zizzari, Bin Yang, Isabelle Dugail, Fatiha Merabtene, Karine Clement, Louise Eygret, Nathalie Dupuy, Jean-Christophe Delpech, Moïra Rossitto, Matthias Mack, Thierry Lesté-Lasserre, Brian Finan, Daniela Cota, Carmelo Quarta.
  Diabetes. 2025-04-11.
  10.2337/db24-1071
• Efficient enrichment of plasma-derived extracellular vesicles from small volumes of bovine blood
  Vincent Prieur, Cassar-Malek Isabelle, Delavaud Arnaud, Barry-Carroll Liam, Delpech Jean-Christophe, Morel Isabelle, Lerch Sylvain, Viala Didier, Chennell Philip, Boby Céline, Bonnet Muriel.
  Journal of Animal Science. 2025-01-01. 103
  10.1093/jas/skaf354
• Modified neuroimmune processes and emotional behaviour in weaned and late adolescent male and female mice born via caesarean section.
  Mathieu Di Miceli, Moïra Rossitto, Maud Martinat, Flore Marchaland, Sarah Kharbouche, Marion Graland, Farah Younes, Alexandra Séré, Agnès Aubert, Lydia Rabbaa Khabbaz, Charlotte Madore, Jean-Christophe Delpech, Rebeca Martín, Sophie Layé.
  Sci Rep. 2024-11-30. 14(1)
  10.1038/s41598-024-80770-y
• Aging, sex, metabolic and life experience factors: contributions to neuro-inflammaging in Alzheimer’s disease research.
  Pasindu Hansana Singhaarachchi, Peter Antal, Frédéric Calon, Carsten Culmsee, Jean-Christophe Delpech, Martin Feldotto, Jorine Geertsema, Emmy E. Hoeksema, Aniko Korosi, Sophie Layé, Jonathan McQualter, Susanne R. de Rooij, Christoph Rummel, Mary Slayo, Luba Sominsky, Sarah J. Spencer.
  Neuroscience & Biobehavioral Reviews. 2024-07-01. 162 : 105724.
  10.1016/j.neubiorev.2024.105724
• Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease
  Zhuoran Yin, Shawn Herron, Sebastian Silveira, Kilian Kleemann, Christian Gauthier, Dania Mallah, Yiran Cheng, Milica A. Margeta, Kristen M. Pitts, Jen-Li Barry, Ayshwarya Subramanian, Hannah Shorey, Wesley Brandao, Ana Durao, Jean-Christophe Delpech, Charlotte Madore, Mark Jedrychowski, Amrendra K. Ajay, Gopal Murugaiyan, Samuel W. Hersh, Seiko Ikezu, Tsuneya Ikezu, Oleg Butovsky.
  Nat Neurosci. 2023-06-08. 26(7) : 1196-1207.
  10.1038/s41593-023-01355-y
• Using mechanical homogenization to isolate microglia from mouse brain tissue to preserve transcriptomic integrity
  Shawn Herron, Jean-Christophe Delpech, Charlotte Madore, Tsuneya Ikezu.
  STAR Protocols. 2022-12-01. 3(4) : 101670.
  10.1016/j.xpro.2022.101670
• Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits
  Diankun Yu, Tao Li, Jean-Christophe Delpech, Beika Zhu, Priya Kishore, Tatsuhiro Koshi, Rong Luo, Karishma J.B. Pratt, Galina Popova, Tomasz J. Nowakowski, Saul A. Villeda, Xianhua Piao.
  Sci. Adv.. 2022-05-06. 8(18)
  10.1126/sciadv.abm2545
• N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice.
  Fanny Decoeur, Katherine Picard, Marie-Kim St-Pierre, Andrew D. Greenhalgh, Jean-Christophe Delpech, Alexandra Sere, Sophie Layé, Marie-Eve Tremblay, Agnès Nadjar.
  Front. Cell. Neurosci.. 2022-02-10. 16
  10.3389/fncel.2022.802411
• Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice.
  Jean-Christophe Delpech, Dhruba Pathak, Merina Varghese, Srinidhi Venkatesan Kalavai, Emma C. Hays, Patrick R. Hof, W. Evan Johnson, Seiko Ikezu, Maria Medalla, Jennifer I. Luebke, Tsuneya Ikezu.
  Sci. Transl. Med.. 2021-09-15. 13(611)
  10.1126/scitranslmed.abe8455
• Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
  Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C. Saido, Seiko Ikezu, Tsuneya Ikezu.
  Mol Neurodegeneration. 2021-04-14. 16(1)
  10.1186/s13024-021-00447-2
• Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
  Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C. Saido, Seiko Ikezu, Tsuneya Ikezu.
  Mol Neurodegeneration. 2021-03-22. 16(1)
  10.1186/s13024-021-00440-9
• Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain.
  C. Madore, Q. Leyrolle, L. Morel, M. Rossitto, A. D. Greenhalgh, J. C. Delpech, M. Martinat, C. Bosch-Bouju, J. Bourel, B. Rani, C. Lacabanne, A. Thomazeau, K. E. Hopperton, S. Beccari, A. Sere, A. Aubert, V. De Smedt-Peyrusse, C. Lecours, K. Bisht, L. Fourgeaud, S. Gregoire, L. Bretillon, N. Acar, N. J. Grant, J. Badaut, P. Gressens, A. Sierra, O. Butovsky, M. E. Tremblay, R. P. Bazinet, C. Joffre, A. Nadjar, S. Layé.
  Nat Commun. 2020-11-30. 11(1)
  10.1038/s41467-020-19861-z
• P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice.
  Zhi Ruan, Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, Alicia A. Van Enoo, Jianqiao Hu, Seiko Ikezu, Tsuneya Ikezu.
  Mol Neurodegeneration. 2020-08-18. 15(1)
  10.1186/s13024-020-00396-2
• Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities.
  Seiko Ikezu, Hana Yeh, Jean-Christophe Delpech, Maya E. Woodbury, Alicia A. Van Enoo, Zhi Ruan, Sudhir Sivakumaran, Yang You, Carl Holland, Teresa Guillamon-Vivancos, Asuka Yoshii-Kitahara, Mina B. Botros, Charlotte Madore, Pin-Hao Chao, Ankita Desani, Solaiappan Manimaran, Srinidhi Venkatesan Kalavai, W. Evan Johnson, Oleg Butovsky, Maria Medalla, Jennifer I. Luebke, Tsuneya Ikezu.
  Mol Psychiatry. 2020-02-18.
  10.1038/s41380-020-0671-2
• Cre-inducible Adeno Associated Virus-mediated Expression of P301L Mutant Tau Causes Motor Deficits and Neuronal Degeneration in the Substantia Nigra.
  Yang You, Mina B. Botros, Alicia A. Van Enoo, Aaron Bockmiller, Shawn Herron, Jean Christophe Delpech, Tsuneya Ikezu.
  Neuroscience. 2019-12-01. 422 : 65-74.
  10.1016/j.neuroscience.2019.10.001
• Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease.
  Jean-Christophe Delpech, Shawn Herron, Mina B. Botros, Tsuneya Ikezu.
  Trends in Neurosciences. 2019-05-01. 42(5) : 361-372.
  10.1016/j.tins.2019.02.007
• Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain
  C. Rey, J.C. Delpech, C. Madore, A. Nadjar, A.D. Greenhalgh, C. Amadieu, A. Aubert, V. Pallet, C. Vaysse, S. Layé, C. Joffre.
  Brain, Behavior, and Immunity. 2019-02-01. 76 : 17-27.
  10.1016/j.bbi.2018.07.025
• Blood biomarkers for evaluation of perinatal encephalopathy: state of the art.
  Ernest M. Graham, Allen D. Everett, Jean-Christophe Delpech, Frances J. Northington.
  Current Opinion in Pediatrics. 2018-04-01. 30(2) : 199-203.
  10.1097/mop.0000000000000591
• Amygdala hyper-connectivity in a mouse model of unpredictable early life stress.
  Frances K. Johnson, Jean-Christophe Delpech, Garth J. Thompson, Lan Wei, Jin Hao, Peter Herman, Fahmeed Hyder, Arie Kaffman.
  Transl Psychiatry. 2018-02-21. 8(1)
  10.1038/s41398-018-0092-z
• Dynamic cross-talk between microglia and peripheral monocytes underlies stress-induced neuroinflammation and behavioral consequences.
  Eric S. Wohleb, Jean-Christophe Delpech.
  Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017-10-01. 79 : 40-48.
  10.1016/j.pnpbp.2016.04.013
• Circulating bacterial lipopolysaccharide-induced inflammation reduces flow in brain-irrigating arteries independently from cerebrovascular prostaglandin production.
  Frédéric Villéga, Jean-Christophe Delpech, Marion Griton, Caroline André, Jean-Michel Franconi, Sylvain Miraux, Jan Pieter Konsman.
  Neuroscience. 2017-03-01. 346 : 160-172.
  10.1016/j.neuroscience.2017.01.018
• Early life stress perturbs the maturation of microglia in the developing hippocampus.
  Jean-Christophe Delpech, Lan Wei, Jin Hao, Xiaoqing Yu, Charlotte Madore, Oleg Butovsky, Arie Kaffman.
  Brain, Behavior, and Immunity. 2016-10-01. 57 : 79-93.
  10.1016/j.bbi.2016.06.006
• Microglia in neuronal plasticity: Influence of stress
  Jean-Christophe Delpech, Charlotte Madore, Agnes Nadjar, Corinne Joffre, Eric S. Wohleb, Sophie Layé.
  Neuropharmacology. 2015-09-01. 96 : 19-28.
  10.1016/j.neuropharm.2014.12.034
• Dietary n-3 PUFAs Deficiency Increases Vulnerability to Inflammation-Induced Spatial Memory Impairment
  Jean-Christophe Delpech, Aurore Thomazeau, Charlotte Madore, Clementine Bosch-Bouju, Thomas Larrieu, Chloe Lacabanne, Julie Remus-Borel, Agnès Aubert, Corinne Joffre, Agnès Nadjar, Sophie Layé.
  Neuropsychopharmacol. 2015-05-07. 40(12) : 2774-2787.
  10.1038/npp.2015.127
• Microglial Activation Enhances Associative Taste Memory through Purinergic Modulation of Glutamatergic Neurotransmission
  J.-C. Delpech, N. Saucisse, S. L. Parkes, C. Lacabanne, A. Aubert, F. Casenave, E. Coutureau, N. Sans, S. Laye, G. Ferreira, A. Nadjar.
  Journal of Neuroscience. 2015-02-18. 35(7) : 3022-3033.
  10.1523/jneurosci.3028-14.2015
• Nutritional n-3 PUFAs deficiency during perinatal periods alters brain innate immune system and neuronal plasticity-associated genes
  Charlotte Madore, Agnès Nadjar, Jean-Christophe Delpech, A. Sere, A. Aubert, Céline Portal, Corinne Joffre, Sophie Layé.
  Brain, Behavior, and Immunity. 2014-10-01. 41 : 22-31.
  10.1016/j.bbi.2014.03.021
• Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation
  Jean-Christophe Delpech, Charlotte Madore, Corinne Joffre, Agnès Aubert, Jing Xuan Kang, Agnès Nadjar, Sophie Layé.
  Neuropsychopharmacol. 2014-08-05. 40(3) : 525-536.
  10.1038/npp.2014.196
• Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging
  Julie Sauvant, Jean-Christophe Delpech, Karine Palin, Nadia De Mota, Jennifer Dudit, Agnès Aubert, Hélène Orcel, Pascale Roux, Sophie Layé, Françoise Moos, Catherine Llorens-Cortes, Agnès Nadjar.
  PLoS ONE. 2014-02-05. 9(2) : e87421.
  10.1371/journal.pone.0087421
• Early morphofunctional plasticity of microglia in response to acute lipopolysaccharide
  C. Madore, C. Joffre, J.C. Delpech, V. De Smedt-Peyrusse, A. Aubert, L. Coste, S. Layé, A. Nadjar.
  Brain, Behavior, and Immunity. 2013-11-01. 34 : 151-158.
  10.1016/j.bbi.2013.08.008
• Long term adequate n-3 polyunsaturated fatty acid diet protects from depressive-like behavior but not from working memory disruption and brain cytokine expression in aged mice
  Aurélie Moranis, Jean-Christophe Delpech, Véronique De Smedt-Peyrusse, Agnès Aubert, Philippe Guesnet, Monique Lavialle, Corinne Joffre, Sophie Layé.
  Brain, Behavior, and Immunity. 2012-07-01. 26(5) : 721-731.
  10.1016/j.bbi.2011.11.001