Fabien Wagner
Team leader
Researcher / CNRS/ Contact
www.orcid.org/0000-0002-9582-6109
/ Address of work
Centre Broca Nouvelle-Aquitaine - bureau 348
Career
Trained first as an engineer and then as a neuroscientist, I conduct research at the intersection between Neuroscience and Neuroengineering. I am interested in understanding how the dynamics of neuronal networks become altered in neurological disorders or after injury, and how to restore their natural behaviour using neuromodulation approaches. During my Ph.D. at Brown University, I developed new tools to record and stimulate the brain simultaneously and investigated the cortical dynamics that underlie the transition to epileptic seizures in rodent models and epileptic patients. During my postdoctoral work at the Ecole Polytechnique Fédérale de Lausanne (EPFL), I pioneered neuroprosthetic technologies to restore locomotion in non-human primates (Nature 2016; Nature Protocols 2018). I then led a large team of scientists, engineers and clinicians to translate these technologies into patients with spinal cord injury in the context of a first-in-human clinical trial (Nature, 2018).
As a team leader within the Institute of Neurodegenerative Diseases at the Bordeaux Neurocampus, I am now interested in expanding the use of neuroprosthetic systems beyond their current applications in motor disorders, towards neurocognitive disorders such as memory impairments and dementia.
Scientific articles
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Neuroprosthetics: from sensorimotor to cognitive disorders
Ankur Gupta, Nikolaos Vardalakis, Fabien B. Wagner.
Comm Biol. 2023-01-06.
10.1038/s42003-022-04390-w -
The neurons that restore walking after paralysis.
Claudia Kathe, Michael A. Skinnider, Thomas H. Hutson, Nicola Regazzi, Matthieu Gautier, Robin Demesmaeker, Salif Komi, Steven Ceto, Nicholas D. James, Newton Cho, Laetitia Baud, Katia Galan, Kaya J. E. Matson, Andreas Rowald, Kyungjin Kim, Ruijia Wang, Karen Minassian, John O. Prior, Leonie Asboth, Quentin Barraud, Stéphanie P. Lacour, Ariel J. Levine, Fabien Wagner, Jocelyne Bloch, Jordan W. Squair, Grégoire Courtine.
Nature. 2022-11-09. 611(7936) : 540-547.
10.1038/s41586-022-05385-7 -
Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis
Andreas Rowald, Salif Komi, Robin Demesmaeker, Edeny Baaklini, Sergio Daniel Hernandez-Charpak, Edoardo Paoles, Hazael Montanaro, Antonino Cassara, Fabio Becce, Bryn Lloyd, Taylor Newton, Jimmy Ravier, Nawal Kinany, Marina D’Ercole, Aurélie Paley, Nicolas Hankov, Camille Varescon, Laura McCracken, Molywan Vat, Miroslav Caban, Anne Watrin, Charlotte Jacquet, Léa Bole-Feysot, Cathal Harte, Henri Lorach, Andrea Galvez, Manon Tschopp, Natacha Herrmann, Moïra Wacker, Lionel Geernaert, Isabelle Fodor, Valentin Radevich, Katrien Van Den Keybus, Grégoire Eberle, Etienne Pralong, Maxime Roulet, Jean-Baptiste Ledoux, Eleonora Fornari, Stefano Mandija, Loan Mattera, Roberto Martuzzi, Bruno Nazarian, Stefan Benkler, Simone Callegari, Nathan Greiner, Benjamin Fuhrer, Martijn Froeling, Nik Buse, Tim Denison, Rik Buschman, Christian Wende, Damien Ganty, Jurriaan Bakker, Vincent Delattre, Hendrik Lambert, Karen Minassian, Cornelis A. T. van den Berg, Anne Kavounoudias, Silvestro Micera, Dimitri Van De Ville, Quentin Barraud, Erkan Kurt, Niels Kuster, Esra Neufeld, Marco Capogrosso, Leonie Asboth, Fabien B. Wagner, Jocelyne Bloch, Grégoire Courtine.
Nat Med. 2022-02-07.
10.1038/s41591-021-01663-5 -
Spinal Cord Stimulation to Enable Leg Motor Control and Walking in People with Spinal Cord Injury
Ismael Seáñez, Marco Capogrosso, Karen Minassian, Fabien B. Wagner.
Neurorehabilitation Technology. 2022-01-01. : 369-399.
10.1007/978-3-031-08995-4_18 -
MRI‐Compatible and Conformal Electrocorticography Grids for Translational Research
Florian Fallegger, Giuseppe Schiavone, Elvira Pirondini, Fabien B. Wagner, Nicolas Vachicouras, Ludovic Serex, Gregory Zegarek, Adrien May, Paul Constanthin, Marie Palma, Mehrdad Khoshnevis, Dirk Van Roost, Blaise Yvert, Grégoire Courtine, Karl Schaller, Jocelyne Bloch, Stéphanie P. Lacour.
Adv. Sci.. 2021-03-08. : 2003761.
10.1002/advs.202003761 -
Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury
J. W. Squair, M. Gautier, L. Mahe, J.E. Soriano, A Rowald, A. Bichat, N. Cho, M. A. Anderson, N. D. James, J. Gandar, A. V. Incognito, G. Schiavone, Z. K. Sarafis, A. Laskaratos, K. Bartholdi, R. Demesmaeker, S. Komi, C. Moerman, B. Vaseghi, B. Scott, R. Rosentreter, C. Kathe, J. Ravier, L. McCracken, X. Kang, N. Vachicouras, F. Fallegger, I. Jelescu, Y. Cheng, Q. Li, R. Buschman, N. Buse, T. Denison, S. Dukelow, R. Charbonneau, I. Rigby, S. K. Boyd, P.J. Millar, E. M. Moraud, M. Capogrosso, F. B. Wagner, Q. Barraud, E. Bezard, S. P. Lacour, J. Bloch, G. Courtine, A. A. Phillips.
Nature. 2021-01-27.
10.1038/s41586-020-03180-w -
Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury
Emanuele Formento, Karen Minassian, Fabien Wagner, Jean Baptiste Mignardot, Camille G. Le Goff-Mignardot, Andreas Rowald, Jocelyne Bloch, Silvestro Micera, Marco Capogrosso, Gregoire Courtine.
Nat Neurosci. 2018-10-31. 21(12) : 1728-1741.
10.1038/s41593-018-0262-6 -
Targeted neurotechnology restores walking in humans with spinal cord injury
Fabien B. Wagner, Jean-Baptiste Mignardot, Camille G. Le Goff-Mignardot, Robin Demesmaeker, Salif Komi, Marco Capogrosso, Andreas Rowald, Ismael Seáñez, Miroslav Caban, Elvira Pirondini, Molywan Vat, Laura A. McCracken, Roman Heimgartner, Isabelle Fodor, Anne Watrin, Perrine Seguin, Edoardo Paoles, Katrien Van Den Keybus, Grégoire Eberle, Brigitte Schurch, Etienne Pralong, Fabio Becce, John Prior, Nicholas Buse, Rik Buschman, Esra Neufeld, Niels Kuster, Stefano Carda, Joachim von Zitzewitz, Vincent Delattre, Tim Denison, Hendrik Lambert, Karen Minassian, Jocelyne Bloch, Grégoire Courtine.
Nature. 2018-10-31. 563(7729) : 65-71.
10.1038/s41586-018-0649-2 -
Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics.
Marco Capogrosso, Fabien B. Wagner, Jerome Gandar, Eduardo Martin Moraud, Nikolaus Wenger, Tomislav Milekovic, Polina Shkorbatova, Natalia Pavlova, Pavel Musienko, Erwan Bezard, Jocelyne Bloch, Grégoire Courtine.
Nat Protoc. 2018-09-01. 13(9) : 2031-2061.
10.1038/s41596-018-0030-9 -
Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model.
Giuseppe Schiavone, Fabien Wagner, Florian Fallegger, Xiaoyang Kang, Nicolas Vachicouras, Beatrice Barra, Marco Capogrosso, Jocelyne Bloch, Gregoire Courtine, Stephanie P. Lacour.
2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). 2018-07-01.
10.1109/embc.2018.8512584 -
A brain-spine interface alleviating gait deficits after spinal cord injury in primates.
Marco Capogrosso, Tomislav Milekovic, David Borton, Fabien Wagner, Eduardo Martin Moraud, Jean-Baptiste Mignardot, Nicolas Buse, Jerome Gandar, Quentin Barraud, David Xing, Elodie Rey, Simone Duis, Yang Jianzhong, Wai Kin D. Ko, Qin Li, Peter Detemple, Tim Denison, Silvestro Micera, Erwan Bezard, Jocelyne Bloch, Grégoire Courtine.
Nature. 2016-11. 539(7628) : 284:288.
10.1038/nature20118 -
Erratum: Integrated device for combined optical neuromodulation and electrical recording for chronic in vivo applications (Journal of Neural Engineering (2012) 9 (016001))
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J. Neural Eng.. 2016-05-06. 13(3) : 039501.
10.1088/1741-2560/13/3/039501 -
Microscale spatiotemporal dynamics during neocortical propagation of human focal seizures.
Fabien B. Wagner, Emad N. Eskandar, G. Rees Cosgrove, Joseph R. Madsen, Andrew S. Blum, N. Stevenson Potter, Leigh R. Hochberg, Sydney S. Cash, Wilson Truccolo.
NeuroImage. 2015-11-01. 122 : 114-130.
10.1016/j.neuroimage.2015.08.019 -
Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury.
Rubia van den Brand, Jean-Baptiste Mignardot, Joachim von Zitzewitz, Camille Le Goff, Nicolas Fumeaux, Fabien Wagner, Marco Capogrosso, Eduardo Martin Moraud, Silvestro Micera, Brigitte Schurch, Armin Curt, Stefano Carda, Jocelyne Bloch, Grégoire Courtine.
Annals of Physical and Rehabilitation Medicine. 2015-09-01. 58(4) : 232-237.
10.1016/j.rehab.2015.04.003 -
Optogenetically induced spatiotemporal gamma oscillations and neuronal spiking activity in primate motor cortex.
Yao Lu, Wilson Truccolo, Fabien B. Wagner, Carlos E. Vargas-Irwin, Ilker Ozden, Jonas B. Zimmermann, Travis May, Naubahar S. Agha, Jing Wang, Arto V. Nurmikko.
Journal of Neurophysiology. 2015-06-01. 113(10) : 3574-3587.
10.1152/jn.00792.2014 -
Modified toolbox for optogenetics in the nonhuman primate.
Ji Dai, Ilker Ozden, Daniel I. Brooks, Fabien Wagner, Travis May, Naubahar S. Agha, Benjamin Brush, David Borton, Arto V. Nurmikko, David L. Sheinberg.
Neurophoton. 2015-05-29. 2(3) : 031202.
10.1117/1.NPh.2.3.031202 -
Spatiotemporal dynamics of optogenetically induced and spontaneous seizure transitions in primary generalized epilepsy.
Fabien B. Wagner, Wilson Truccolo, Jing Wang, Arto V. Nurmikko.
Journal of Neurophysiology. 2015-04-01. 113(7) : 2321-2341.
10.1152/jn.01040.2014 -
Detection of optogenetic stimulation in somatosensory cortex by non-human primates–towards artificial tactile sensation.
Travis May, Ilker Ozden, Benjamin Brush, David Borton, Fabien Wagner, Naubahar Agha, David L. Sheinberg, Arto V. Nurmikko.
PLoS ONE. 2014-12-26. 9(12) : e114529.
10.1371/journal.pone.0114529 -
Integrated device for combined optical neuromodulation and electrical recording for chronic in vivo applications.
Jing Wang, Fabien Wagner, David A Borton, Jiayi Zhang, Ilker Ozden, Rebecca D Burwell, Arto V Nurmikko, Rick van Wagenen, Ilka Diester, Karl Deisseroth.
J. Neural Eng.. 2011-12-07. 9(1) : 016001.
10.1088/1741-2560/9/1/016001 -
Approaches to optical neuromodulation from rodents to non-human primates by integrated optoelectronic devices.
Jing Wang, I. Ozden, M. Diagne, F. Wagner, D. Borton, B. Brush, N. Agha, R. Burwell, D. Sheinberg, I. Diester, K. Deisseroth, A. Nurmikko.
2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2011-08-01.
10.1109/iembs.2011.6091855