Fabien Wagner
Team leader
Researcher / CNRS/ Contact
www.orcid.org/0000-0002-9582-6109
/ Address of work
Centre Broca Nouvelle-Aquitaine - bureau 348
Career
Trained first as an engineer and then as a neuroscientist, I conduct research at the intersection between Neuroscience and Neuroengineering. I am interested in understanding how the dynamics of neuronal networks become altered in neurological disorders or after injury, and how to restore their natural behaviour using neuromodulation approaches. During my Ph.D. at Brown University, I developed new tools to record and stimulate the brain simultaneously and investigated the cortical dynamics that underlie the transition to epileptic seizures in rodent models and epileptic patients. During my postdoctoral work at the Ecole Polytechnique Fédérale de Lausanne (EPFL), I pioneered neuroprosthetic technologies to restore locomotion in non-human primates (Nature 2016; Nature Protocols 2018). I then led a large team of scientists, engineers and clinicians to translate these technologies into patients with spinal cord injury in the context of a first-in-human clinical trial (Nature, 2018).
As a team leader within the Institute of Neurodegenerative Diseases at the Bordeaux Neurocampus, I am now interested in expanding the use of neuroprosthetic systems beyond their current applications in motor disorders, towards neurocognitive disorders such as memory impairments and dementia.
Scientific articles
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Augmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept
Sci. Robot.. 2025-03-12. 10(100)
10.1126/scirobotics.adn5564 -
A dynamical computational model of theta generation in hippocampal circuits to study theta-gamma oscillations during neurostimulation
eLife. 2023-02-14.
10.7554/eLife.87356.3 -
Neuroprosthetics: from sensorimotor to cognitive disorders
Comm Biol. 2023-01-06.
10.1038/s42003-022-04390-w -
The neurons that restore walking after paralysis.
Nature. 2022-11-09. 611(7936) : 540-547.
10.1038/s41586-022-05385-7 -
Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis
Nat Med. 2022-02-07.
10.1038/s41591-021-01663-5 -
Spinal Cord Stimulation to Enable Leg Motor Control and Walking in People with Spinal Cord Injury
Neurorehabilitation Technology. 2022-01-01. : 369-399.
10.1007/978-3-031-08995-4_18 -
MRI‐Compatible and Conformal Electrocorticography Grids for Translational Research
Adv. Sci.. 2021-03-08. : 2003761.
10.1002/advs.202003761 -
Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury
Nature. 2021-01-27.
10.1038/s41586-020-03180-w -
Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury
Nat Neurosci. 2018-10-31. 21(12) : 1728-1741.
10.1038/s41593-018-0262-6 -
Targeted neurotechnology restores walking in humans with spinal cord injury
Nature. 2018-10-31. 563(7729) : 65-71.
10.1038/s41586-018-0649-2 -
Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics.
Nat Protoc. 2018-09-01. 13(9) : 2031-2061.
10.1038/s41596-018-0030-9 -
Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model.
2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). 2018-07-01.
10.1109/embc.2018.8512584 -
A brain-spine interface alleviating gait deficits after spinal cord injury in primates.
Nature. 2016-11. 539(7628) : 284:288.
10.1038/nature20118 -
Erratum: Integrated device for combined optical neuromodulation and electrical recording for chronic in vivo applications (Journal of Neural Engineering (2012) 9 (016001))
J. Neural Eng.. 2016-05-06. 13(3) : 039501.
10.1088/1741-2560/13/3/039501 -
Microscale spatiotemporal dynamics during neocortical propagation of human focal seizures.
NeuroImage. 2015-11-01. 122 : 114-130.
10.1016/j.neuroimage.2015.08.019 -
Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury.
Annals of Physical and Rehabilitation Medicine. 2015-09-01. 58(4) : 232-237.
10.1016/j.rehab.2015.04.003 -
Optogenetically induced spatiotemporal gamma oscillations and neuronal spiking activity in primate motor cortex.
Journal of Neurophysiology. 2015-06-01. 113(10) : 3574-3587.
10.1152/jn.00792.2014 -
Modified toolbox for optogenetics in the nonhuman primate.
Neurophoton. 2015-05-29. 2(3) : 031202.
10.1117/1.NPh.2.3.031202 -
Spatiotemporal dynamics of optogenetically induced and spontaneous seizure transitions in primary generalized epilepsy.
Journal of Neurophysiology. 2015-04-01. 113(7) : 2321-2341.
10.1152/jn.01040.2014 -
Detection of optogenetic stimulation in somatosensory cortex by non-human primates–towards artificial tactile sensation.
PLoS ONE. 2014-12-26. 9(12) : e114529.
10.1371/journal.pone.0114529 -
Integrated device for combined optical neuromodulation and electrical recording for chronic in vivo applications.
J. Neural Eng.. 2011-12-07. 9(1) : 016001.
10.1088/1741-2560/9/1/016001 -
Approaches to optical neuromodulation from rodents to non-human primates by integrated optoelectronic devices.
2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2011-08-01.
10.1109/iembs.2011.6091855