Postdoctoral Position in Neuroscience and Auditory Neurodegenerative disorders
We are looking for a highly-motivated candidate to work in a Fondation Pour l’Audition supported project (at least 2 1/2 years) dissecting the mechanisms of Sensorineural hearing loss associated with hair cell polarization defects. The candidate will work with an interdisciplinary team using cellular & molecular biology, anatomy and behavior (Mireille Montcouquiol, Inserm and Neurocentre Magendie at the Bordeaux Neurocampus) and electrophysiology techniques (Didier Dulon, Inserm Bordeaux Neurocampus and Institut pour l’Audition Paris) to understand the auditory hair cell maturation. The project focuses on how genetic mutations that disrupt polarity mechanisms cause sensorineural deafness and associated deficits in the central nervous system (see Mauriac et al., Nat Commun. 2017 7;8:14907). We want to dissect the functional changes occurring at the mechanosensitive structures of the auditory hair cells, the hair bundles, but also at the auditory ribbon synapses in mouse models (see Dulon et al., J Clin Invest. 2018 Aug 1;128(8):3382-3401.; Vincent et al., Cell Rep. 2018 Dec 18;25(12):3451-3464.)
The ideal candidate should have a Ph.D. in Neuroscience and have previous experience with whole cell patch-clamp electrophysiology and calcium imaging. Expertise in electrophysiology of the central nervous system (notably the cortex or the hippocampus) is a plus. Depending on CV quality and motivation, there is a possibility to apply for a tenured position by the end of the postdoct.
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