Impromptu seminar – Robert Kalb
“The intricacy of glutamatergic synapses – some new players in the game”
During early postnatal life, synaptic activity within circuits sculpt connectivity among neurons. NMDA-R mediated activity-dependent development during a critical period has been well explored and other pathways exist, operate in parallel, that are NMDA-R independent. Evidence is provided for a plasticity channel that involves AMPA-R assembled with GluA1, the synaptic scaffolding protein SAP97 and specific SAP97-binding partners including CRIPT.
While the cell biological processes governed by GluA1/SAP97/CRIPT are just beginning to be explored, they are likely to be critical for normal brain function.
See more.. http://kalbneuron.com/ Kalb Neuronal Biology Laboratory
Genetic induction of hypometabolism by ablation of MC4R does not suppress ALS-like phenotypes in the G93A mutant SOD1 mouse model. Doshi S, Gupta P, Kalb RG. Sci Rep. 2017 Oct 13;7(1):13150. doi: 10.1038/s41598-017-13304-4.
Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration. Mor DE, Tsika E, Mazzulli JR, Gould NS, Kim H, Daniels MJ, Doshi S, Gupta P, Grossman JL, Tan VX, Kalb RG, Caldwell KA, Caldwell GA, Wolfe JH, Ischiropoulos H. Nat Neurosci. 2017 Nov;20(11):1560-1568. doi: 10.1038/nn.4641. Epub 2017 Sep 18.