Lieu : Institut de Mathématiques de Bordeaux (Bâtiment A33) sur le campus de Talence (351 cours de la Libération, 33405 Talence) en Salle de Conférence (à l’entrée du bâtiment)
Etant donné le protocole sanitaire en place, il est préférable, pour ceux qui le souhaitent, d’assister à la présentation en ligne, la capacité maximum de l’amphithéâtre après application du protocole sanitaire étant de 50 places. La soutenance sera donc retransmise en direct à l’adresse suivante :
Team : GIN (IMN)
Defense : in french
“Elaboration Of Brain Network Atlases Underpinning Lateralized Cognitive Functions, Application To The Study Of Inter-individual Variability Of Language”
My thesis work is part of a multi-modal and multi-scale integration approach which has led to the emergence of cognitive and population neuroimaging. More specifically, fMRI provides two types of three-dimensional functional brain maps: activation maps allowing for visualizing brain regions directly involved in a cognitive process, and intrinsic connectivity maps measuring the synchronization between spatially distant but functionally connected regions. I have applied new statistical methodologies to these two types of maps, allowing me to deal with both the individual and the spatial dimensions. In the first part, I designed atlases of brain regions dedicated to specific cognitive functions, based on their hemispheric lateralization and targeting a population selected for its low variability. I present here the first two language atlases. Indeed, although there are many approaches to map language areas in patients, there was no atlas of networks supporting language functions in healthy individuals so far. I first identified left activated and left asymmetrical regions, both during sentence production, listening and reading, in 137 healthy right-handed individuals. Analysis of the intrinsic connectivity between the 32 identified regions reveals that they are part of 3 distinct functional networks, which constitute the SENSAAS (SENtence Supramodal Areas AtlaS) brain atlas. Among these networks, one with 18 regions contains the essential language areas (SENT_CORE), i.e. the brain areas whose lesion leads to an impairment in the integration of the meaning of speech. Specifically, SENT_CORE contains 3 hubs supporting the information integration and dissemination, localized in the Broca and Wernicke area. I then applied this methodology to the elaboration of an atlas of word processing networks. I identified 21 brain regions organized into 2 distinct networks, one of which is a phonological network including the audio-motor loop. For the first time, a strong intrinsic connectivity between the left audio-motor loop and the prosodic processing, located in the upper temporal sulcus of the right hemisphere, is evidenced. Finally, I developed a new method for studying the variability of three-dimensional data. This new method includes two different mathematical tools based on hierarchical agglomerative clustering algorithms. The first one makes it possible to identify variables leading to partition instability, the second one allows for extracting stable sub-populations from a starting population. The applications of all of this work are numerous: for example, I used the SENT_CORE network to study the inter-individual variability of hemispheric lateralization of the sentence supramodal areas. I have thus identified two groups of typical asymmetric left language individuals, with high left intra-hemispheric intrinsic connectivity and low inter-hemispheric connectivity, and a group of atypical individuals: rightward asymmetrical for language, with high intrinsic connectivity of language networks in both hemispheres and high inter-hemispheric connectivity. SENSAAS has also been used to study the genetic support of language atypicality, as well as for the topological characterization of the memory and language networks of individuals with mesial temporal lobe epilepsy. The new method for assessing inter-individual variability was used to evaluate the stability of the intrinsic networks of a new functional atlas adapted for late adulthood.
Keywords : Cognitive Neuroscience, Machine Learning, Network Theory, fMRI, Neuroimaging, Language, Intrinsic Connectivity, Hemispheric Specialization
- Labache L., Joliot M., Saracco J., Jobard G., Hesling I., Zago L., Mellet E., Petit L., Crivello F., Mazoyer B., Tzourio-Mazoyer N. (2019). A SENtence Supramodal Areas AtlaS (SENSAAS) based on multiple task-induced activation mapping and graph analysis of intrinsic connectivity in 144 healthy right-handers. Brain Structure and Function. 224: 859-882.
- Hesling I., Labache L., Joliot M., Tzourio-Mazoyer N. (2019). Large-Scale plurimodal networks common to listening, production and reading word-lists: an fMRI study combining tasks-induced activation and intrinsic connectivity in 144 right-handers. Brain Structure and Function. 224: 3075-3094.
- Labache L., Mazoyer B., Joliot M., Crivello F., Hesling I., Tzourio-Mazoyer N. (2020). Typical and atypical language brain organization according to intrinsic connectivity and multitasks functional asymmetries. Accepted at eLife.
- Doucet G., Labache L., Joliot M., Frangou S. (2020). Atlas55+: Brain Functional Atlas of Resting-state Networks for Healthy Late Adulthood. Accepted at Cerebral Cortex.
- Labache L., Joliot M., Doucet G., Saracco J. (2020). Study of inter-individual variability of three-dimensional data table: detection of unstable variables and samples. Submitted to Computational Statistics.
- Tzourio-Mazoyer N., Labache L., Zago L., Hesling I., Mazoyer B. (2020). Neural support of manual preference based on right and left during right and left finger-tapping induced activations and resting-state connectivity in 287 healthy adults balanced for handedness. Submitted to Laterality.
- Zago L., Labache L., Tzourio-Mazoyer N., Mazoyer B. (2020). Atlas of Lateralized Attention Networks (ALANs) in right-handers. bioRxiv.
Dr Jérôme Saracco, Professeur des Universités, Université de Bordeaux, co-directeur de thèse
Dr Marc Joliot, Directeur de Recherche, Université de Bordeaux, co-directeur de thèse
Dr Nathalie Tzourio-Mazoyer, Directrice de Recherche, Université de Bordeaux, examinatrice & directrice de thèse CEA
Dr Monica Baciu, Professeuse des Universités, Université de Grenoble, rapporteure
Dr Julie Jacques, Professeur des Universités, Université de Lyon, rapporteur
Dr Sarah Genon, Research Group Leader, Heinrich Heine University Düsseldorf, examinatrice