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Seminar – Laura Palagini

18 November 2022 / 11:30

Venue: Centre Broca

Laura Palagini
Assistant Professor of Psychiatry Department of Neuroscience
University of Ferrara, Italy

Twitter : @laurapalagini

Invited by Pierre Philip, Sanpsy


Insomnia and psychopathology of mental disorders


While sleep serves important regulatory functions for mental health, sleep disturbances, in particular Insomnia, may favor a state of allostatic overload impairing brain neuroplasticity, stress immune pathways hence contributing to mental disorders. In this framework, the aim of this talk is to discuss current understanding about insomnia mechanisms with current knowledge about mental health dysregulatory mechanisms. The focus of the present talk will be on mood, anxiety and psychotic disorders which represent important challenges in the clinical practice. Insomnia may play as a risk factor, a comorbid condition and transdiagnostic symptom for many mental disorders including mood/anxiety disorders and schizophrenia. Insomnia may play as a marker of disrupted neuroplasticity contributing to dysregulate different nurobiological mechanisms involved in these different mental conditions. In this framework, insomnia treatment may not only regulate sleep processes but also the stress system, neuroinflammation and brain plasticity.  Insomnia treatment may play and important preventive and neuroprotective role with CBT-Insomnia being the treatment with important new evidence of efficacy on insomnia, psychopathology and indices of disrupted neuroplasticity. Pharmacological pathways for insomnia treatment in these mental conditions are still not well defined. Indeed new therapeutic options acting on orexinergic and melatonergic systems may represents important pathways of interventions which may open new windows on insomnia treatment in mental disorders

Insomnia, mental health, anxiety, mood disorders, bipolar disorders, neuroplasticity, new therapeutic strategies for insomnia

Key publications

Palagini L, Hertenstein E, Riemann D, Nissen C. Sleep, insomnia and mental health.
J Sleep Res. 2022 Aug;31(4):e13628.

Palagini L, Geoffroy PA, Miniati M, Perugi G, Biggio G, Marazziti D, Riemann D. Insomnia, sleep loss, and circadian sleep disturbances in mood disorders: a pathway toward neurodegeneration and neuroprogression? A theoretical review.
CNS Spectr. 2022 Jun;27(3):298-308.

Palagini L, Bianchini C. Pharmacotherapeutic management of insomnia and effects on sleep processes, neural plasticity, and brain systems modulating stress: A narrative review.
Front Neurosci. 2022 Jul 29;16:893015.

Palagini L, Miniati M, Marazziti D, Franceschini C, Zerbinati L, Grassi L, Sharma V, Riemann D. Insomnia symptoms are associated with impaired resilience in bipolar disorder: Potential links with early life stressors may affect mood features and suicidal risk.
J Affect Disord. 2022 Feb 15;299:596-603.

Palagini L, Geoffroy PA, Riemann D. Sleep Markers in Psychiatry: Do Insomnia and Disturbed Sleep Play as Markers of Disrupted Neuroplasticity in Mood Disorders? A Proposed Model.
Curr Med Chem. 2022;29(35):5595-5605

Geoffroy PA, Palagini L. Biological rhythms and chronotherapeutics in depression
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 2;106:110158

Palagini L, Manni R, Aguglia E, Amore M, Brugnoli R, Bioulac S, Bourgin P, Micoulaud Franchi JA, Girardi P, Grassi L, Lopez R, Mencacci C, Plazzi G, Maruani J, Minervino A, Philip P, Royant Parola S, Poirot I, Nobili L, Biggio G, Schroder CM, Geoffroy PA International Expert Opinions and Recommendations on the Use of Melatonin in the Treatment of Insomnia and Circadian Sleep Disturbances in Adult Neuropsychiatric Disorders.
Front Psychiatry. 2021 Jun 10;12:688890.

Palagini L, Miniati M, Marazziti D, Sharma V, Riemann D. Association among early life stress, mood features, hopelessness and suicidal risk in bipolar disorder: The potential contribution of insomnia symptoms.
J Psychiatr Res. 2021 Mar;135:52-59.

Palagini L, Miniati M, Caruso D, Massa L, Novi M, Pardini F, Salarpi G, Pini S, Marazziti D, Etain B, Riemann D. Association between affective temperaments and mood features in bipolar disorder II: The role of insomnia and chronobiological rhythms desynchronization.
J Affect Disord. 2020 Apr 1;266:263-272.

Palagini L, Manni R, Aguglia E, Amore M, Brugnoli R, Girardi P, Grassi L, Mencacci C, Plazzi G, Minervino A, Nobili L, Biggio G. Expert Opinions and Consensus Recommendations for the Evaluation and Management of Insomnia in Clinical Practice: Joint Statements of Five Italian Scientific Societies.
Front Psychiatry. 2020 Jun 26;11:558.

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18 November 2022
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