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Seminar – Joana Lourenço

24 February 2023 / 11:30

Venue: Centre Broca Nouvelle-Aqutaine

Joana Lourenço
ICM, Paris

Invited by Giovanni Marsicano (Magendie)


Cortical perisomatic inhibition:  a tale of two interneurons


Cortical perisomatic inhibition onto pyramidal neurons is provided by two major interneuron classes: parvalbumin- and cholecystokinin-containing basket cells. Both basket cell subtypes exhibit unique functional synaptic and plasticity properties. I will discuss how they can differentially sculpt pyramidal-neuron output activity during cognitive-relevant network activity.

Key publications

  • Koukouli F, Montmerle M, Aguirre A, De Brito Van Velze M, Peixoto J, Choudhary V, Varilh M, Julio-Kalajzic F, Allene C, Mendéz P, Zerlaut Y, Marsicano G, Schlüter OM, Rebola N, Bacci A, Lourenço J. Visual-area-specific tonic modulation of GABA release by endocannabinoids sets the activity and coordination of neocortical principal neurons. Cell Rep. 2022 Aug 23;40(8):111202.doi: 10.1016/j.celrep.2022.111202.
  • Lourenço J, Koukouli F, Bacci A. Synaptic inhibition in the neocortex: Orchestration and computation through canonical circuits and variations on the theme. 2020 Nov;132:258-280.
  • Lourenço J, De Stasi AM, Deleuze C, Bigot M, Pazienti A, Aguirre A, Giugliano M, Ostojic S, Bacci A. Modulation of Coordinated Activity across Cortical Layers by Plasticity of Inhibitory Synapses. Cell Rep. 2020 Jan 21;30(3):630-641.e5.
  • Lourenço J, Pacioni S, Rebola N, van Woerden GM, Marinelli S, DiGregorio D, Bacci A: Non-associative potentiation of perisomatic inhibition alters the temporal coding of neocortical layer 5 pyramidal neurons. PLoS Biol. 2014Jul 8;12(7):e1001903
  • Lourenço J, Cannich A, Carta M, Coussen F, Mulle C, Marsicano G: Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses. Nat Neurosci. 2010 Feb;13(2):197-204
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24 February 2023
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