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Seminar – Andrew Sharott

Friday 13 November 2020 / 11:30 - 12:30

Closing the loop: phase-dependent modulation of cortico-basal ganglia circuits. 

Dr Andrew Sharott
MRC Brain Network Dynamics Unit, Oxford, UK

Invited by Thomas Bienvenu, Neurocentre Magendie and Nicolas Mallet, IMN


Closed-loop neuromodulation, whereby features of ongoing brain signals are used to control the timing of electrical or optical stimulation, has the potential to provide precise methods for the manipulation of functional and dysfunctional neuronal activity. Neuronal oscillations provide an attractive input signal for such closed-loop modulation, as they provide a robust signal to inform the timing of stimulation. As oscillations are a fundamental property of normal brain activity, modulating their strength and manipulating synchronization will likely influence brain function and ongoing behavior. Computational studies suggest pulsatile perturbations timed to a specific phase of an oscillation can modulate neural oscillators by shifting the relative timing of neuronal activity. Using a combination of preclinical and clinical physiology and bioengineering experiments, we have developed a viable system for utilizing such phase-dependent closed-loop stimulation to modulate pathological beta-frequency oscillations in Parkinson’s disease. In addition to providing a novel therapeutic strategy, these methods could allow the manipulation of a wide range of oscillatory activities to causally examine the role of rhythmicity in the healthy brain.

Key Publications

Cagnan H, Mallet N, Moll CKE, Gulberti A, Holt AB, Westphal M, Gerloff C, Engel AK, Hamel W, Magill PJ, Brown P, Sharott A (2019) Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network. Proc Natl Acad Sci U S A. 116:16095-16104.

Holt AB, Kormann E, Gulberti A, Pötter-Nerger M, McNamara CG, Cagnan H, Baaske MK, Little S, Köppen JA, Buhmann C, Westphal M, Gerloff C, Engel AK, Brown P, Hamel W, Moll CKE, Sharott A (2019) Phase-Dependent Suppression of Beta Oscillations in Parkinson’s Disease Patients. J Neurosci. 39:1119-1134.

Sharott, A, Gulberti A, Zittel S, Tudor Jones AA, Fickel U, Münchau A, Köppen JA, Gerloff, C, Westphal M, Buhmann C, Hamel W, Engel AK, Moll CK (2014) Activity parameters of subthalamic nucleus neurons selectively predict motor symptom severity in Parkinson’s disease. J Neurosci. 34: 6273-85.

Sharott A, Magill PJ, Harnack D, Kupsch A, Meissner W, Brown P (2005) Dopamine

depletion increases the power and coherence of beta-oscillations in the cerebral cortex and subthalamic nucleus of the awake rat. Eur J Neurosci. 21:1413-22.

Seminar organized with the support of Bordeaux Neurocampus

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Friday 13 November 2020
11:30 - 12:30
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