Venue: Centre Broca
Wojciech Krezel
IGBMC – CNRS UMR 7104 – Inserm U 1258
67404 Illkirch
https://www.igbmc.fr/igbmc/missions/annuaire/wojciech-krezel
Invited by Clémentine Bosch-Bouju (NutriNeuro)
Topic
Vitamin A5/X and episodic memory
Abstract
Vitamin A5/X, a recently identified new class of vitamin A has been proposed to control episodic memory, but the exact cellular and physiological substrates of such modulations remain unknown. We have shown that 9-cis-13,14-dihydroretinoic acid (9CDHRA), an active form of vitamin A5/X is an endogenous ligand of Retinoid X Receptors (RXRα, β, γ), a group of nuclear hormone receptors acting as ligand-regulated transcription factors. We found that RXRγ is functionally predominant RXR in mediating pro-mnemonic activities of 9CDHRA in spatial working memory tasks. Using whole-cell recordings and somatic ablation of RXRγ in the hippocampus in mice we determined that RXRγ controls activities of hilar mossy cells), a group of hilar excitatory interneurons in dentate gyrus and that such regulation may be relevant for control of pattern separation and working memory performance in mice. We speculate that such regulations might be also pertinent for understanding of the vitamin A5/X signaling in control of mnemonic functions.
Associated publications
- Krzyzosiak, A.; Szyszka-Niagolov, M.; Wietrzych, M.; Gobaille, S.; Muramatsu, S.; Krezel, W. Retinoid x Receptor Gamma Control of Affective Behaviors Involves Dopaminergic Signaling in Mice. Neuron 2010, 66 (6), 908–920. https://doi.org/10.1016/j.neuron.2010.05.004.
- Wietrzych-Schindler, M.; Szyszka-Niagolov, M.; Ohta, K.; Endo, Y.; Pérez, E.; de Lera, A. R.; Chambon, P.; Krezel, W. Retinoid x Receptor Gamma Is Implicated in Docosahexaenoic Acid Modulation of Despair Behaviors and Working Memory in Mice. Biol. Psychiatry 2011, 69 (8), 788–794. https://doi.org/10.1016/j.biopsych.2010.12.017.
- Rühl, R.; Krezel, W.; de Lera, A. R. 9-Cis-13,14-Dihydroretinoic Acid, a New Endogenous Mammalian Ligand of Retinoid X Receptor and the Active Ligand of a Potential New Vitamin A Category: Vitamin A5. Nutr Rev 2018, 76 (12), 929–941. https://doi.org/10.1093/nutrit/nuy057.
- Sharma, S.; Shen, T.; Chitranshi, N.; Gupta, V.; Basavarajappa, D.; Sarkar, S.; Mirzaei, M.; You, Y.; Krezel, W.; Graham, S. L.; Gupta, V. Retinoid X Receptor: Cellular and Biochemical Roles of Nuclear Receptor with a Focus on Neuropathological Involvement. Mol Neurobiol 2022, 59 (4), 2027–2050. https://doi.org/10.1007/s12035-021-02709-y.