Venue: Centre Broca
Dr. Aleksandra Deczkowska
Institut Pasteur, Paris, France
https://research.pasteur.fr/en/team/brain-immune-communication/
https://www.aleksdelab.com/
https://bsky.app/profile/aleksdelab.bsky.social
Invited by Giulia Cutugno (Neurocentre Magendie)
Title
Immune regulation of brain physiology through the CSF
Abstract
Peripheral immune cells modulate brain activities in physiology, but they are rarely found in direct contact with the neural tissue. Similarly, microbial products can shape brain development and aging, yet no commensal bacteria are found in the healthy brain. We hypothesize that such peripheral immune and microbial signals affect the brain remotely and indirectly, from its borders, anatomical structures, which separate the central nervous system from the periphery. Using tool of immunology, neuroscience and genomics, we aim to identify mechanisms of such remote immune and microbial influence by focusing on the choroid plexus (blood-CSF barrier) and the skull marrow niche in the context of brain development, aging and Alzheimer’s disease.
Key publications
Immune control of brain physiology.
Kovacs M, Dominguez-Belloso A, Ali-Moussa S, Deczkowska A.Nat Rev Immunol. 2025 Jul;25(7):515-527. doi: 10.1038/s41577-025-01129-6. Epub 2025 Jan 31.PMID: 39890999
Microbial and immune factors regulate brain maintenance and aging.
Travier L, Singh R, Sáenz Fernández D, Deczkowska A.Curr Opin Neurobiol. 2022 Oct;76:102607. doi: 10.1016/j.conb.2022.102607. Epub 2022 Jul 29.PMID: 35914431
PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer’s disease.
Baruch K, Deczkowska A, Rosenzweig N, Tsitsou-Kampeli A, Sharif AM, Matcovitch-Natan O, Kertser A, David E, Amit I, Schwartz M.Nat Med. 2016 Feb;22(2):135-7. doi: 10.1038/nm.4022. Epub 2016 Jan 18.PMID: 26779813
Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner.
Deczkowska A, Matcovitch-Natan O, Tsitsou-Kampeli A, Ben-Hamo S, Dvir-Szternfeld R, Spinrad A, Singer O, David E, Winter DR, Smith LK, Kertser A, Baruch K, Rosenzweig N, Terem A, Prinz M, Villeda S, Citri A, Amit I, Schwartz M.Nat Commun. 2017 Sep 28;8(1):717. doi: 10.1038/s41467-017-00769-0.PMID: 28959042
Aging-induced type I interferon response at the choroid plexus negatively affects brain function.
Baruch K, Deczkowska A, David E, Castellano JM, Miller O, Kertser A, Berkutzki T, Barnett-Itzhaki Z, Bezalel D, Wyss-Coray T, Amit I, Schwartz M.Science. 2014 Oct 3;346(6205):89-93. doi: 10.1126/science.1252945. Epub 2014 Aug 21.PMID: 25147279
Meet the speaker!
You are a research staff ? Write to ">Julia Goncalves who will organize the schedule.
You are a PhD student? You can register to share some pizza after the talk. Registration opens 3 weeks before.
PhD seminars are organized by the NBA, Bordeaux Neurocampus, and the Bordeaux Neurocampus Graduate Program.
