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Monthly PhD seminar – Markus Heilig

Friday 5 April 2019 / 11:30

Molecular mechanisms of alcohol addiction : How we got alcohol addiction wrong, one lever at a time.

Lieu : Centre Broca Nouvelle-Aquitaine

Markus Heilig
Markus Heilig

Markus Heilig
Professor of Neuro Psychiatry
Department of Clinical and Experimental Medicine (IKE)
Center for Social and Affective Neuroscience (CSAN)

Invité par la NBA et Bordeaux Neurocampus dans le cadre des PhD seminars


Abstract

Alcohol use is an ongoing public health crisis, and effective treatments are largely lacking. Neurobiological research has grown exponentially in the past two decades, and has become increasingly sophisticated in its ability to identify neural circuits behind alcohol seeking and taking in animal models. To date, however, these advances have not translated into novel clinical treatments.

This talk will discuss potential limitations of drug discovery strategies that use animal models where drug seeking is studied in isolation, using conventional self-administration in groups of animals. It will introduce the critical importance of phenomena that are key to clinical alcohol addiction: individual variation in vulnerability, choice of alcohol over natural rewards, and continued use of alcohol despite adverse consequences. These concepts will be discussed in the context of our recent discoveries implicating GABA-transmission in central amygdala as a key process to target with novel medications.

Recent key references

1. Augier E, Barbier E, Dulman RS, Licheri V, Augier G, Domi E, Barchiesi R, Farris S, Natt D, Mayfield RD, Adermark L, Heilig M. 2018. A molecular mechanism for choosing alcohol over an alternative reward. Science 360: 1321-6

2. Grodin EN, Sussman L, Sundby K, Brennan GM, Diazgranados N, Heilig M, Momenan R. 2018. Neural Correlates of Compulsive Alcohol Seeking in Heavy Drinkers. Biol Psychiatry Cogn Neurosci Neuroimaging 3: 1022-31

3. Barbier E, Johnstone AL, Khomtchouk BB, Tapocik JD, Pitcairn C, Rehman F, Augier E, Borich A, Schank JR, Rienas CA, Van Booven DJ, Sun H, Natt D, Wahlestedt C, Heilig M. 2017. Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2. Molecular Psychiatry 22: 1746-58

4. Barbier E, Tapocik JD, Juergens N, Pitcairn C, Borich A, Schank JR, Sun H, Schuebel K, Zhou Z, Yuan Q, Vendruscolo LF, Goldman D, Heilig M. 2015. DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity. J Neurosci 35: 6153-64

5. Heilig M, Epstein DH, Nader MA, Shaham Y. 2016. Time to connect: bringing social context into addiction neuroscience. Nat Rev Neurosci 17: 592-9


 

Coming soon

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    Wednesday 19 June 2019 / 11:30 - Friday 18 October 2019 / 12:30

    Invited by Giovanni Marsicano

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    Tuesday 15 October 2019 - Wednesday 30 October 2019

    Applications will open in April 2019

  3. Village du CNRS

    Thursday 17 October 2019 - Monday 21 October 2019

    A l'occasion des 80 ans.

  4. Monthly conference (PhD seminar series) – Deborah Kurrasch

    Thursday 31 October 2019 / 11:30 - 12:30

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  5. Seminar – Michael Ugrumov

    Thursday 31 October 2019 / 14:00 - 15:00

    Development of preclinical diagnosis of neurodegenerative diseases – illusion or reality?

Details

Date:
Friday 5 April 2019
Time:
11:30
Event Category: