Why bother using non-human primate models of cognitive disorders in translational research?
Neurobiology of Learning and Memory. 2015-10-01; 124: 123-129
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1. Neurobiol Learn Mem. 2015 Oct;124:123-9. doi: 10.1016/j.nlm.2015.06.012. Epub
2015 Jun 29.
Why bother using non-human primate models of cognitive disorders in translational
Camus S(1), Ko WK(1), Pioli E(1), Bezard E(2).
(1)Motac Neuroscience Ltd, Manchester, United Kingdom.
(2)Motac Neuroscience Ltd, Manchester, United Kingdom; Univ. de Bordeaux,
Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France;
CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux,
Although everyone would agree that successful translation of therapeutic
candidates for central nervous disorders should involve non-human primate (nhp)
models of cognitive disorders, we are left with the paucity of publications
reporting either the target validation or the actual preclinical testing in
heuristic nhp models. In this review, we discuss the importance of nhps in
translational research, highlighting the advances in technological/methodological
approaches for ‘bridging the gap’ between preclinical and clinical experiments.
In this process, we acknowledge that nhps remain a vital tool for the
investigation of complex cognitive functions, given their resemblance to humans
in aspects of behaviour, anatomy and physiology. The recent improvements made for
a suitable nhp model in cognitive research, including new surrogates of disease
and application of innovative methodological approaches, are continuous strides
for reaching efficient translation for human benefit. This will ultimately aid
the development of innovative treatments against the current and future threat of
neurological and psychiatric disorders to the global population.
Copyright © 2015 Elsevier Inc. All rights reserved.
PMID: 26135120 [Indexed for MEDLINE]