The real-life effectiveness of psychosocial therapies on social autonomy in schizophrenia patients: Results from a nationwide cohort study in France

Aminata Ali, Arnaud Carre, Massimiliano Orri, Mathieu Urbach, Caroline Barry, Christine Hassler, Bruno Falissard, Sylvie Berthoz, Clementine Nordon
Psychiatry Research. 2017-01-01; 247: 97-104
DOI: 10.1016/j.psychres.2016.10.048

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1. Psychiatry Res. 2017 Jan;247:97-104. doi: 10.1016/j.psychres.2016.10.048. Epub
2016 Nov 9.

The real-life effectiveness of psychosocial therapies on social autonomy in
schizophrenia patients: Results from a nationwide cohort study in France.

Ali A(1), Carre A(2), Orri M(1), Urbach M(3), Barry C(1), Hassler C(1),
Falissard B(1), Berthoz S(4), Nordon C(5).

Author information:
(1)CESP, Paris-Sud University, Paris-Saclay University, INSERM, 16 avenue Paul
Vaillant-Couturier, 94805 Villejuif, France.
(2)CESP, Paris-Sud University, Paris-Saclay University, INSERM, 16 avenue Paul
Vaillant-Couturier, 94805 Villejuif, France; Savoie Mont Blanc University, LIPP
C2S EA 4145, Domaine Universitaire de Jacob, BP1104, 73000 Chambéry, France.
(3)Centre Expert Schizophrénie, Versailles Hospital Centre,177 rue de
Versailles, 78157 Le Chesnay cedex, France.
(4)Institute for Cognitive and Integrative Neuroscience, 146 rue Léo Saignat,
33000 Bordeaux, France.
(5)CESP, Paris-Sud University, Paris-Saclay University, INSERM, 16 avenue Paul
Vaillant-Couturier, 94805 Villejuif, France; LASER Analytica, 10 place de
Catalogne, 75014 Paris, France. Electronic address:
.

The objectives of the present study were to describe the prescribing patterns
for psychosocial therapies in routine clinical practice and to assess the impact
of psychoeducation on symptoms and social autonomy of patients with
schizophrenia. We used data from the nationwide French ESPASS observational
cohort study including 5967 patients with schizophrenia, which provided data on
exposure to psychosocial therapies from 4961 (83%) participants. Patients who
initiated psychosocial therapy within the first 3 months of study onset (n=143)
were compared to patients not subject to psychosocial therapy throughout follow
up (n=4268), using parametric tests. Symptom severity and social autonomy at 6
months from baseline were compared between patients undergoing psychoeducation
(n=117) and patients not subject to psychosocial therapy, matched (1:1) on
propensity scores. Patients who initiated psychosocial therapy were
significantly younger, more severely ill and used less often antipsychotic drugs
than patients in the reference group. At 6 months, patients who initiated
psychoeducation and their matched referents did not differ significantly in
terms of symptom severity, but their level of improvement in social autonomy was
significantly greater (p=0.005). In routine clinical practice, psychoeducation
in addition to antipsychotic drugs provides some benefit among schizophrenia
patients, particularly in terms of social autonomy.

Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

DOI: 10.1016/j.psychres.2016.10.048
PMID: 27886580 [Indexed for MEDLINE]

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