The hidden side of Parkinson’s disease: studying pain, anxiety and depression in animal models.
Neuroscience & Biobehavioral Reviews. 2019-01-01; 96: 335-352
DOI: 10.1016/j.neubiorev.2018.10.004
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1. Neurosci Biobehav Rev. 2018 Oct 23. pii: S0149-7634(18)30505-0. doi:
10.1016/j.neubiorev.2018.10.004. [Epub ahead of print]
The hidden side of Parkinson’s disease: studying pain, anxiety and depression in
animal models.
Faivre F(1), Joshi A(1), Bezard E(2), Barrot M(3).
Author information:
(1)Centre National de la Recherche Scientifique, Université de Strasbourg,
Institut des Neurosciences Cellulaires et Intégratives, F-67000 Strasbourg,
France.
(2)Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293,
F-33000 Bordeaux, France; Centre National de la Recherche Scientifique, Institut
des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.
(3)Centre National de la Recherche Scientifique, Université de Strasbourg,
Institut des Neurosciences Cellulaires et Intégratives, F-67000 Strasbourg,
France. Electronic address: .
Parkinson’s disease is a neurodegenerative disease leading to the loss of
midbrain dopamine neurons. It is well known and characterized by motor symptoms
that are secondary to the loss of dopamine innervation, but it is also
accompanied by a range of various non-motor symptoms, including pain and
psychiatric disorders such as anxiety and depression. These non-motor symptoms
usually appear at early stages of the disease, sometimes even before the first
motor symptoms, and have a dramatic impact on the quality of life of the
patients. We review here the present state-of-the-art concerning pain, anxiety
and depression-like parameters in animal models of Parkinson’s disease.
Copyright © 2018. Published by Elsevier Ltd.
DOI: 10.1016/j.neubiorev.2018.10.004
PMID: 30365972