The 68 symptoms of the clinical high risk for psychosis: Low similarity among fourteen screening questionnaires
Psychiatry Research. 2023-12-01; 330: 115592
DOI: 10.1016/j.psychres.2023.115592
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Bernardin F(1), Gauld C(2), Martin VP(3), Laprévote V(4), Dondé C(5).
Author information:
(1)Centre Psychothérapique de Nancy, Pôle Transversal Médico-Technique et
Clinique, Centre de, Liaison et d’Intervention Précoce, Laxou F-54520, France;
Institut National de la Santé et de la Recherche Médical, INSERM U1114, Pôle de
Psychiatrie, Fédération de Médecine Translationnelle de Strasbourg, Centre
Hospitalier Régional Universitaire, de Strasbourg, Université de Strasbourg,
Strasbourg, France. Electronic address: .
(2)Department of Child Psychiatry, Université de Lyon, 59 Bd Pinel, Lyon
F-69000, France; Université Claude Bernard Lyon 1, CNRS, INSERM, Centre de
Recherche en Neurosciences de, Lyon CRNL U1028 UMR5292, PSYR2, Bron F-69500,
France.
(3)Univ. Bordeaux, CNRS, Bordeaux INP, LaBRI, UMR 5800, Talence F-33400, France;
Univ. Bordeaux, CNRS, SANPSY, UMR 6033, Bordeaux F-33000, France.
(4)Centre Psychothérapique de Nancy, Pôle Transversal Médico-Technique et
Clinique, Centre de, Liaison et d’Intervention Précoce, Laxou F-54520, France;
Institut National de la Santé et de la Recherche Médical, INSERM U1114, Pôle de
Psychiatrie, Fédération de Médecine Translationnelle de Strasbourg, Centre
Hospitalier Régional Universitaire, de Strasbourg, Université de Strasbourg,
Strasbourg, France; Université de Lorraine, Faculté de Médecine,
Vandœuvre-lès-Nancy F-54500 France.
(5)Univ. Grenoble Alpes, Grenoble F-38000, France; INSERM, U1216, Grenoble
F-38000, France; Psychiatry Department, CHU Grenoble Alpes, Grenoble F-38000,
France. Electronic address: .
The Clinical High Risk for psychosis (CHR) is a heterogeneous condition with
multiple symptoms. CHR screening is challenging in routine care, as a wide
variety of questionnaires exists. We propose to explore the extent to which
these questionnaires differ or overlap in item content. We performed a
systematic and quantitative analysis of item content in a set of widely-used CHR
screening questionnaires. Items were extracted from questionnaires and reworded
according to the Structured Interview for Psychosis-Risk Syndromes (SIPS). Then,
symptoms were generated from individual items. The Jaccard Index was calculated
to assess content overlap. The 14 analysed questionnaires were composed of 347
items, from which 198 symptoms were generated and, in turn, collapsed into 68
distinct symptoms. Positive symptoms were the most commonly represented. The
overall overlap across questionnaires showed weak similarity
(Jaccard = 0.19±0.50). CHR screening questionnaires might evaluate the same
broad clinical construct, but have different scopes within that construct, and
may be more or less comprehensive than one another. Clinicians and researchers
should be mindful of the specific features of each instrument for optimal CHR
screening.
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