Temporal binding function of dorsal CA1 is critical for declarative memory formation

Azza Sellami, Alice Shaam Al Abed, Laurent Brayda-Bruno, Nicole Etchamendy, Stéphane Valério, Marie Oulé, Laura Pantaléon, Valérie Lamothe, Mylène Potier, Katy Bernard, Maritza Jabourian, Cyril Herry, Nicole Mons, Pier-Vincenzo Piazza, Howard Eichenbaum, Aline Marighetto
Proc Natl Acad Sci USA. 2017-09-05; 114(38): 10262-10267
DOI: 10.1073/pnas.1619657114

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1. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10262-10267. doi:
10.1073/pnas.1619657114. Epub 2017 Sep 5.

Temporal binding function of dorsal CA1 is critical for declarative memory
formation.

Sellami A(1)(2), Al Abed AS(1)(2), Brayda-Bruno L(1)(2), Etchamendy N(1)(2),
Valério S(1)(2), Oulé M(1)(2), Pantaléon L(1)(2), Lamothe V(1)(2), Potier
M(1)(2), Bernard K(3), Jabourian M(3), Herry C(1)(2), Mons N(2)(4), Piazza
PV(1)(2), Eichenbaum H(5), Marighetto A(6)(2).

Author information:
(1)Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U1215,
INSERM, F-33000 Bordeaux, France.
(2)Université de Bordeaux, F-33000 Bordeaux, France.
(3)Institut de Recherche Internationale Servier, 92150 Suresnes, France.
(4)Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, UMR 5287,
CNRS, F-33600 Pessac, France.
(5)Center for Memory and Brain, Boston University, Boston, MA 02215.
(6)Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U1215,
INSERM, F-33000 Bordeaux, France; .

Temporal binding, the process that enables association between discontiguous
stimuli in memory, and relational organization, a process that enables the
flexibility of declarative memories, are both hippocampus-dependent and decline
in aging. However, how these two processes are related in supporting declarative
memory formation and how they are compromised in age-related memory loss remain
hypothetical. We here identify a causal link between these two features of
declarative memory: Temporal binding is a necessary condition for the relational
organization of discontiguous events. We demonstrate that the formation of a
relational memory is limited by the capability of temporal binding, which depends
on dorsal (d)CA1 activity over time intervals and diminishes in aging.
Conversely, relational representation is successful even in aged individuals when
the demand on temporal binding is minimized, showing that relational/declarative
memory per se is not impaired in aging. Thus, bridging temporal intervals by dCA1
activity is a critical foundation of relational representation, and a
deterioration of this mechanism is responsible for the age-associated memory
impairment.

DOI: 10.1073/pnas.1619657114
PMCID: PMC5617244
PMID: 28874586 [Indexed for MEDLINE]

Conflict of interest statement: The authors declare no conflict of interest.


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