Subtle health impairment and socioeducational attainment in young adult patients with congenital hypothyroidism diagnosed by neonatal screening: A longitudinal population-based cohort study
The Journal of Clinical Endocrinology & Metabolism. 2011-06-01; 96(6): 1771-1782
DOI: 10.1210/jc.2010-2315
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1. J Clin Endocrinol Metab. 2011 Jun;96(6):1771-82. doi: 10.1210/jc.2010-2315. Epub
2011 Mar 9.
Subtle health impairment and socioeducational attainment in young adult patients
with congenital hypothyroidism diagnosed by neonatal screening: a longitudinal
population-based cohort study.
Léger J(1), Ecosse E, Roussey M, Lanoë JL, Larroque B; French Congenital
Hypothyroidism Study Group.
Collaborators: Farriaux JP, Stuckens C, Weill J, Boudailliez B, Bony H, Sulmont
V, Souchon PF, Leheup B, Juif J, Soskin S, Bertrand AM, Huet F, Dorche C, David
M, Nicolino M, Sarles J, Maurin N, Reynaud R, Sarda P, Rochiccioli P, Tauber M,
Barat P, Kayemba S, Berthelot J, Coutant R, Baron S, de Kerdanet M, Naud-Saudreau
C, Metz C, Travert G, Lecointre C, Despert F, Lienhart A, Malpuech G, Alberti C,
Briard ML, Czernichow P, Carel JC, Gelwane G, Polak M, Raux-Demay MC, Rodrigues
D, Toublanc JE.
Author information:
(1)Pediatric Endocrinology Department, Centre de Référence Maladies
Endocriniennes Rares de la Croissance, Institut National de la Santé et de la
Recherche Médicale Unité 676, Hôpital Robert Debré, 48 Bd Sérurier, 75019 Paris,
France.
Comment in
J Clin Endocrinol Metab. 2011 Jun;96(6):1671-3.
CONTEXT: Screening programs resulting in the early treatment of patients with
congenital hypothyroidism (CH) have successfully improved neurodevelopmental
outcome, but little is known about long-term health.
OBJECTIVES: The aim of the study was to assess health status, and socioeconomic
attainment, for a population-based registry of young adult patients.
DESIGN, SETTING, AND PARTICIPANTS: All 1748 eligible patients diagnosed during
the first decade after the introduction of neonatal screening in France were
invited to participate in this study at a median age of 23.4 yr. Completed
questionnaires were obtained from 1202 of the selected patients. The comparison
group included 5817 subjects from the last French Decennial Health Survey.
MAIN OUTCOME MEASURES: Health indicators including medical conditions, hearing
and visual status, sociodemographic characteristics, and quality of life were
measured.
RESULTS: Patients with CH were significantly more likely than their peers to
report associated chronic diseases (5.7 vs. 2.9%), hearing impairment (9.5 vs.
2.5%), visual problems (55.4 vs. 47.9%), and being overweight with a body mass
index of at least 25 kg/m(2) (22.8 vs. 15.7%) (P < 0.0001). Furthermore, fewer
patients attained the highest socioeconomic category (14.6 vs. 23.1%) and were in
full-time employment (39.9 vs. 44.8%) (P < 0.0001). They were more likely to
still be living with their parents and had a lower health-related quality of life
than their healthy peers, particularly for mental dimensions, with a mean
difference for the mental summary component of 0.35 SD score (P < 0.0001). CH
severity at diagnosis, treatment adequacy, and the presence of other chronic
health conditions were the main determinants of educational achievement and
health-related quality of life scores.
CONCLUSION: These findings highlight the need for careful monitoring of
neurosensory functioning, weight, and long-term treatment adequacy throughout
childhood and adulthood.
DOI: 10.1210/jc.2010-2315
PMID: 21389139 [Indexed for MEDLINE]