Soft, Implantable Bioelectronic Interfaces for Translational Research.

Giuseppe Schiavone, Florian Fallegger, Xiaoyang Kang, Beatrice Barra, Nicolas Vachicouras, Evgenia Roussinova, Ivan Furfaro, Sébastien Jiguet, Ismael Seáñez, Simon Borgognon, Andreas Rowald, Qin Li, Chuan Qin, Erwan Bézard, Jocelyne Bloch, Grégoire Courtine, Marco Capogrosso, Stéphanie P. Lacour
Adv. Mater.. 2020-03-16; 32(17): 1906512
DOI: 10.1002/adma.201906512

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1. Adv Mater. 2020 Apr;32(17):e1906512. doi: 10.1002/adma.201906512. Epub 2020 Mar

Soft, Implantable Bioelectronic Interfaces for Translational Research.

Schiavone G(1), Fallegger F(1), Kang X(1), Barra B(2), Vachicouras N(1),
Roussinova E(1), Furfaro I(1), Jiguet S(1), Seáñez I(3), Borgognon S(2)(3),
Rowald A(3), Li Q(4)(5), Qin C(4), Bézard E(4)(5)(6)(7), Bloch J(3)(8), Courtine
G(3)(8), Capogrosso M(2), Lacour SP(1).

Author information:
(1)Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft
Bioelectronics Interface, Institute of Microengineering, Institute of
Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de
Lausanne, Geneva, 1202, Switzerland.
(2)Department of Neuroscience and Movement Science, University of Fribourg,
Fribourg, 1700, Switzerland.
(3)Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences,
École Polytechnique Fédérale de Lausanne, Lausanne, 1015, Switzerland.
(4)Institute of Lab Animal Sciences, China Academy of Medical Sciences, Beijing,
100021, China.
(5)Motac Neuroscience Ltd, Manchester, SK10 4TF, UK.
(6)Institut des Maladies Neurodégénératives, University of Bordeaux, Bordeaux,
UMR 5293, France.
(7)CNRS, Institut des Maladies Neurodégénératives, Bordeaux, UMR 5293, France.
(8)Defitech Center for Interventional Neurotherapies (NeuroRestore), Department
of Neurosurgery, University Hospital of Lausanne (CHUV), University of Lausanne
(UNIL), Lausanne, Switzerland.

The convergence of materials science, electronics, and biology, namely
bioelectronic interfaces, leads novel and precise communication with biological
tissue, particularly with the nervous system. However, the translation of
lab-based innovation toward clinical use calls for further advances in materials,
manufacturing and characterization paradigms, and design rules. Herein, a
translational framework engineered to accelerate the deployment of
microfabricated interfaces for translational research is proposed and applied to
the soft neurotechnology called electronic dura mater, e-dura. Anatomy, implant
function, and surgical procedure guide the system design. A high-yield,
silicone-on-silicon wafer process is developed to ensure reproducible
characteristics of the electrodes. A biomimetic multimodal platform that
replicates surgical insertion in an anatomy-based model applies physiological
movement, emulates therapeutic use of the electrodes, and enables advanced
validation and rapid optimization in vitro of the implants. Functionality of
scaled e-dura is confirmed in nonhuman primates, where epidural neuromodulation
of the spinal cord activates selective groups of muscles in the upper limbs with
unmet precision. Performance stability is controlled over 6 weeks in vivo. The
synergistic steps of design, fabrication, and biomimetic in vitro validation and
in vivo evaluation in translational animal models are of general applicability
and answer needs in multiple bioelectronic designs and medical technologies.

© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

DOI: 10.1002/adma.201906512
PMID: 32173913

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