Sleep disorders in Parkinson’s disease: the contribution of the MPTP non-human primate model.

Quentin Barraud, Virginie Lambrecq, Claude Forni, Steve McGuire, Michael Hill, Bernard Bioulac, Emmanuel Balzamo, Erwan Bezard, François Tison, Imad Ghorayeb
Experimental Neurology. 2009-10-01; 219(2): 574-582
DOI: 10.1016/j.expneurol.2009.07.019

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1. Exp Neurol. 2009 Oct;219(2):574-82. doi: 10.1016/j.expneurol.2009.07.019. Epub
2009 Jul 25.

Sleep disorders in Parkinson’s disease: the contribution of the MPTP non-human
primate model.

Barraud Q(1), Lambrecq V, Forni C, McGuire S, Hill M, Bioulac B, Balzamo E,
Bezard E, Tison F, Ghorayeb I.

Author information:
(1)Université Victor Segalen Bordeaux 2, Centre National de la Recherche
Scientifique, Bordeaux Institute of Neuroscience, UMR 5227 and Centre Hospitalier
et Universitaire de Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux cedex, France.

Comment in
Exp Neurol. 2010 Apr;222(2):179-80.

To replicate the sleep-wake disorders of Parkinson’s disease (PD) and to
understand the temporal relationship between these sleep disturbances and the
occurrence of parkinsonism, we performed long-term continuous
electroencephalographic monitoring of vigilance states in unrestrained rhesus
monkeys using an implanted miniaturized telemetry device and tested the effect of
MPTP intoxication on their sleep-wake organization. MPTP injection yielded a
dramatic disruption of sleep-wake architecture with reduced sleep efficacy that
persisted years after MPTP administration. Primary deregulation of REM sleep and
increased daytime sleepiness occurring before the emergence of motor symptoms
were a striking feature of the MPTP effect. This was concomitant with a breakdown
of dopaminergic homeostasis, as evidenced by decreased dopamine turnover measured
after a single MPTP injection. In the long term, partial re-emergence of REM
sleep paralleled the partial adaptation to parkinsonism, the latter being known
to result from compensatory mechanisms within the dopaminergic system.
Altogether, these findings highlight the suitability of the MPTP model of PD as a
tool to model the sleep/wake disturbances of the human disease. Ultimately, this
may help in deciphering the specific role of dopamine depletion in the occurrence
of these disorders.

DOI: 10.1016/j.expneurol.2009.07.019
PMID: 19635479 [Indexed for MEDLINE]

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