Presynaptic glutamate receptors: physiological functions and mechanisms of action.
Nat Rev Neurosci. 2008-05-09; 9(6): 423-436
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1. Nat Rev Neurosci. 2008 Jun;9(6):423-36. doi: 10.1038/nrn2379. Epub 2008 May 9.
Presynaptic glutamate receptors: physiological functions and mechanisms of
Pinheiro PS(1), Mulle C.
(1)Laboratoire Physiologie Cellulaire de la Synapse, Centre National de la
Recherche Scientifique Unite mixte de recherche 5091, Bordeaux Neuroscience
Institute, University of Bordeaux, 33077 Bordeaux, France.
Glutamate acts on postsynaptic glutamate receptors to mediate excitatory
communication between neurons. The discovery that additional presynaptic
glutamate receptors can modulate neurotransmitter release has added complexity to
the way we view glutamatergic synaptic transmission. Here we review evidence of a
physiological role for presynaptic glutamate receptors in neurotransmitter
release. We compare the physiological roles of ionotropic and metabotropic
glutamate receptors in short- and long-term regulation of synaptic transmission.
Furthermore, we discuss the physiological conditions that are necessary for their
activation, the source of the glutamate that activates them, their mechanisms of
action and their involvement in higher brain function.
PMID: 18464791 [Indexed for MEDLINE]