Partial bilateral mesencephalic lesions affect D1 but not D2 binding in both the striatum and cortex.
Neurochemistry International. 2004-12-01; 45(7): 995-1004
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1. Neurochem Int. 2004 Dec;45(7):995-1004.
Partial bilateral mesencephalic lesions affect D1 but not D2 binding in both the
striatum and cortex.
Pioli E(1), Sohr R, Meissner W, Barthe N, Gross CE, Bezard E, Bioulac BH.
(1)Basal Gang, Laboratoire de Physiologie et Physiopathologie de la Signalisation
Cellulaire, CNRS UMR 5543, Université Victor Segalen, 146 rue Léo Saignat, 33076
Bordeaux Cedex, France.
The substantia nigra pars compacta (SNc) and the ventral tegmental area (VTA) are
the two major mesencephalic dopaminergic systems. Mesencephalic dopamine
denervation is followed by long-term modifications in striatum and cortex that
preserve dopamine functions. Here, we have studied the impact of isolated
bilateral 6-hydroxydopamine lesioning of the SNc or the VTA on D(1) and D(2)
dopamine receptor binding in striatal and cortical areas of rat. Neither SNc nor
VTA bilateral partial lesioning changed D(2) binding at the striatal or cortical
level. Intriguingly, only VTA lesioning increased D(1) binding in the cortex,
whereas both bilateral partial lesioning of the SNc or the VTA increased striatal
D(1) binding. This suggests that increased cortical D(1) binding could be an
indicator of VTA lesioning. Further behavioural experiments may explain the
pathophysiological meaning of increased cortical D(1) binding, and determine
whether this observation is involved in compensatory mechanisms.
PMID: 15337298 [Indexed for MEDLINE]