PAR-1 Phosphorylates Mind Bomb to Promote Vertebrate Neurogenesis
Developmental Cell. 2009-08-01; 17(2): 222-233
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Ossipova O(1), Ezan J, Sokol SY.
(1)Department of Developmental and Regenerative Biology, Mount Sinai School of
Medicine, New York, NY 10029, USA.
Dev Cell. 2009 Aug;17(2):153-4.
Generation of neurons in the vertebrate central nervous system requires a complex
transcriptional regulatory network and signaling processes in polarized
neuroepithelial progenitor cells. Here we demonstrate that neurogenesis in the
Xenopus neural plate in vivo and mammalian neural progenitors in vitro involves
intrinsic antagonistic activities of the polarity proteins PAR-1 and aPKC.
Furthermore, we show that Mind bomb (Mib), a ubiquitin ligase that promotes Notch
ligand trafficking and activity, is a crucial molecular substrate for PAR-1. The
phosphorylation of Mib by PAR-1 results in Mib degradation, repression of Notch
signaling, and stimulation of neuronal differentiation. These observations
suggest a conserved mechanism for neuronal fate determination that might operate
during asymmetric divisions of polarized neural progenitor cells.
PMID: 19686683 [Indexed for MEDLINE]