Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease.
Trends in Neurosciences. 2019-05-01; 42(5): 361-372
DOI: 10.1016/j.tins.2019.02.007
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Delpech JC(1), Herron S(1), Botros MB(1), Ikezu T(2).
Author information:
(1)Department of Pharmacology and Experimental Therapeutics, Boston University
School of Medicine, Boston, MA 02118, USA.
(2)Department of Pharmacology and Experimental Therapeutics, Boston University
School of Medicine, Boston, MA 02118, USA; Neurology, Boston University School of
Medicine, Boston, MA 02118, USA. Electronic address: .
The dynamics of CNS function rely upon omnidirectional communication among CNS
cell types. Extracellular vesicles (EVs) have emerged as key mediators of this
communication and are actively involved in response to CNS injury, mediating
inflammatory response and inflammation-related neuroprotection as they display
dual beneficial and detrimental roles. Neuroimmune interactions include
communication between neurons and microglia, the resident macrophages within the
CNS, and these interactions are a critical mediator of healthy brain functions,
mounting an inflammatory response, and disease pathogenesis. This review aims to
organize recent research highlighting the role of EVs in health and
neurodegenerative disorders, with a specific focus on neuroimmune interactions
between neurons and glia in Alzheimer’s disease.
Copyright © 2019 Elsevier Ltd. All rights reserved.